Systemic Effects of Low-Intensity Laser Irradiation on Skin Microcirculation in Patients with Diabetic Microangiopathy

Schindl, Andreas; Heinze, Georg; Schindl, Martin; Pernerstorfer-Schön, Heidemarie; Schindl, Liesbeth

doi:10.1006/mvre.2002.2429

Cited by 125 publications

(78 citation statements)

References 38 publications

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“…However, it is evident that wound healing involves several biological processes at cellular and molecular levels. The research on wound healing targets the cellular and subcellular biomodulation [15][16][17][18][19]. The healing properties of LLLT are likely to be due to photobiomodulation resulting in increased granulation tissue, fibroblast proliferation, collagen synthesis, neovascularization, and early epithelialization, the important changes observed in LLLT-treated wounds.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Low Level Laser Therapy on Wound Healing in Patients with Chronic Diabetic Foot Ulcers—A Randomised Control Trial

et al. 2012

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Foot ulcers are serious complications of Diabetes Mellitus (DM) and are known to be resistant to conventional treatment. They may herald severe complications if not treated wisely. Electromagnetic radiations in the form of photons are delivered to the ulcers in laser form to stimulate healing. This study was conducted to evaluate the efficacy of Low Level Laser Therapy (LLLT) in diabetic ulcer healing dynamics. To determine mean percentage reduction of wound area in study and control groups. Settings: KLES Dr.

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Section: Discussionmentioning

confidence: 99%

Efficacy of Low Level Laser Therapy on Wound Healing in Patients with Chronic Diabetic Foot Ulcers—A Randomised Control Trial

et al. 2012

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“…Since the report of Mester et al [1]. on low-level laser irradiation of mouse skin to investigate wound healing, many researchers have investigated the influence of laser irradiation on wound healing [1][2][3][4][5], improvement of microcirculation [6], nerve activation [7], treatment of chronic pain and anti-inflammation [8]. The influence of low-level laser irradiation on activation of salivary gland cells has been also investigated [9][10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Low-level (gallium-aluminum-arsenide) laser irradiation of Par-C10 cells and acinar cells of rat parotid gland

et al. 2008

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We investigated cell response, including cell proliferation and expression of heat stress protein to clarify the influence of low-level (Ga-Al-As diode) laser irradiation on rat parotid gland acinar cell-derived Par-C10 cells. Furthermore, we also investigated amylase release and cell death to irradiation in rat parotid gland acinar cells. Number of Par-C10 cells in the laser-irradiated groups was higher than that in the non-irradiated group at days 5 and 7, although the difference was statistically significant (p<0.01).Higher expression of HSP25 and bcl-2 was seen at days 1 and 3 in the irradiated group.Amylase release assay showed no significant difference between irradiated group and non-irradiated group statistically. Trypan blue exclusion assay revealed that there was no difference in the ratio of dead to live cells between the irradiated-and non-irradiated groups. These results suggest that low-level laser irradiation promotes cell proliferation and expression of anti-apoptosis proteins in Par-C10 cells, but it does not significantly affect amylase secretion and does not induce rapid cell death in isolated rat parotid gland acinar cells.3

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“…12 We assumed that LLLT applied to the lower face could lead to indirect exposure of the thyroid gland, as 830 nm wavelength lasers can reach deeper planes and exert both local and systemic effects. 5,6,[28][29][30]36,38 The rabbit model was chosen because of the previously reported ease of handling, surgical preparation, and postoperative follow-up. 8,28,34,38 Moreover, the size of these animals enabled the use of conventional implants available for clinical use in humans.…”

Section: Discussionmentioning

confidence: 99%

“…5,[28][29][30] Therefore, LLLT may lead to effects on organs and tissues far from the actual site of application (systemic effects). The literature suggests that LLLT may have repercussions on endocrine function because of potential effects on the secretory glands, 31 including the thyroid gland.…”

Section: Introductionmentioning

confidence: 99%

Effect of Three Different Protocols of Low-Level Laser Therapy on Thyroid Hormone Production After Dental Implant Placement in an Experimental Rabbit Model

Weber

Mayer²,

Cenci³

et al. 2014

Photomedicine and Laser Surgery

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Objective: The purpose of this study was to assess the systemic effects of low-level laser therapy (LLLT) on thyroid gland function and, consequently, calcium regulation -as measured by serum triiodothyronine (T3), thyroxine (T4), and free calcium levels -when administered after dental implant placement in a rabbit model. Background data: Protocols for the use of laser therapy in several clinical procedures are currently under investigation, as not all of the actions and systemic effects of laser irradiation have been clearly established. Materials and methods: Forty male adult New Zealand rabbits were distributed across five groups of eight animals each: two control groups (C-I and C-II) of unirradiated animals, and three experimental groups (E-5, E-10, and E-20), each exposed to a distinct dose of gallium-aluminum-arsenide (GaAlAs) laser [k = 830 nm, 50 mW, continuous wave (CW)] every 48 h for a total of seven sessions. The total dose per session was 5 J/cm 2 in E-5, 10 J/cm 2 in E-10, and 20 J/cm 2 in E-20. Animals in C-II and all experimental groups underwent surgical extraction of the mandibular left incisor followed by immediate placement of an osseointegrated implant (Nanotite Ò , Biomet 3i TM ) into the socket. Animals in group C-I served as an absolute control for T3, T4, and calcium measurements. The level of significance was set at 5% ( p £ 0.05). Results: ANOVA with Tukey's posthoc test revealed significant differences in T3 and calcium levels among experimental groups, as well as significant within-group differences in T3, T4, and calcium levels over time. Conclusions: Although not reaching abnormal values, LLLT applied to the mandible influenced thyroid function in this model.

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Systemic Effects of Low-Intensity Laser Irradiation on Skin Microcirculation in Patients with Diabetic Microangiopathy

Cited by 125 publications

References 38 publications

Efficacy of Low Level Laser Therapy on Wound Healing in Patients with Chronic Diabetic Foot Ulcers—A Randomised Control Trial

Efficacy of Low Level Laser Therapy on Wound Healing in Patients with Chronic Diabetic Foot Ulcers—A Randomised Control Trial

Low-level (gallium-aluminum-arsenide) laser irradiation of Par-C10 cells and acinar cells of rat parotid gland

Effect of Three Different Protocols of Low-Level Laser Therapy on Thyroid Hormone Production After Dental Implant Placement in an Experimental Rabbit Model

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