Systemic Immune-inflammation Index, Based on Platelet Counts and Neutrophil-Lymphocyte Ratio, Is Useful for Predicting Prognosis in Small Cell Lung Cancer

Hong, Xuan; Cui, Baohong; Wang, Meng; Yang, Zhaoyang; Wang, Li; Xu, Qingyong

doi:10.1620/tjem.236.297

Cited by 271 publications

(268 citation statements)

References 39 publications

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“…Several studies have reported that a high PLR is a parameter that reflects systemic inflammatory response in numerous diseases [21,22]. A PLR increase has also been reported to be associated with cardiovascular complications and poor prognosis in malignancies [23,24]. The SII assesses 3 of the hemostatic system markers that participate in the inflammatory process at the same time: platelets, lymphocytes, and neutrophils [13,16].…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, a combined marker of chronic inflammation, such as the SII, reflecting high neutrophils and platelets, and low lymphocytes, may contribute additional information regarding the inflammatory and immunological balance of the body. Interest in the SII has grown recently because it has been found to be predictive of the prognoses of patients with diverse oncological conditions [16,[23][24][25]. There is a strong linkage between obesity, cancer, inflammation, and clinical outcomes [26].…”

Section: Discussionmentioning

confidence: 99%

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Relationship between CRP, systemic immune-inflammation index and routine hemogram related inflammatory markers in low grade inflammation

Üstündağ¹

2018

Int J Med Biochem

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Research ArticleR ecent advances in technology led to the quantitation of new parameters with automated hematology analyzers. Some of these parameters have been accepted as additional markers in diagnosing various clinical conditions [1][2][3][4][5]. They are cost effective and easier to perform in a routine setting than tests for some other markers. C-reactive protein (CRP) is a commonly used inflammation marker in both acute and chronic inflammation. Most healthy individuals have a CRP concentration of 3 mg/L or less; a CRP level higher than 10 mg/L indicates a clinically significant inflammatory disease [6]. Low-grade inflammation typically refers to conditions in which Objectives: The term low-grade inflammation is usually used to indicate chronic conditions in which the findings of classic, clinical inflammation are lacking, but there is an elevated C-reactive protein (CRP) level of 3 to 10 mg/L. Recently, the systemic immune-inflammation index (SII) was developed based on lymphocyte, neutrophil, and platelet counts, which can project the inflammatory and immune imbalances. The aim of this study was to examine the SII and new parameters derived from hemograms to determine if they have the potential to detect patients with subclinical lowgrade inflammation in an unselected, elderly, outpatient population. Methods: The CRP level was analyzed with a BN II System nepholometer (Siemens Healthineers, Erlangen, Germany). Participants were stratified according to CRP level: Group 1 had a serum CRP result <3.0 mg/L and Group 2 had a serum CRP result 3.0-9.0 mg/L. Blood samples that had been analyzed with an automated hematology analyzer (Mindray BC-5800; Mindray Biomedical Electronics Co., Ltd., Shenzhen, China) were selected for evaluation of the results. The SII (neutrophil x platelet / lymphocyte), platelet-to-lymphocyte ratio (PLR), and neutrophil-to-lymphocyte ratio (NLR) were calculated. PLR (r=0.773; p<0.001), and the platelet count (r=0.653; p<0.001) was found. However, there was no correlation between the CRP, SII (r=-0.312; p=0.210), and PLR (r=-0.165; p=0.117). Conclusion: A high PLR and SII appears to be associated with subclinical low-grade inflammation. These data do not support hematological screening parameters as a substitute for CRP. These findings are limited to the cohort studied here, and may not be entirely applicable to other ethnic origins. Keywords: C-reactive protein, lymphocyte, neutrophil, platelet Relationship between C-reactive protein, systemic immuneinflammation index, and routine hemogram-related inflammatory markers in low-grade inflammation

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Relationship between CRP, systemic immune-inflammation index and routine hemogram related inflammatory markers in low grade inflammation

Üstündağ¹

2018

Int J Med Biochem

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“…Several studies have already identified pretherapeutic prognostic markers and scores to predict outcome in SCLC patients [7,8,9,10,11,12,13,14]. A recent study also demonstrated that pretreatment mGPS and PNI are independent predictors of OS in patients with advanced SCLC [14].…”

Section: Discussionmentioning

confidence: 99%

“…For about 30 years, lactate dehydrogenase (LDH) and serum albumin have been described to predict OS in SCLC [7,8,9]. Different markers and scores for acute inflammation, i.e., the neutrophil-to-lymphocyte ratio (NLR), C-reactive protein (CRP) levels, the modified Glasgow prognostic score (mGPS), the prognostic nutritional index (PNI), and the systemic immune-inflammation index (SII) have been associated with poor outcome in SCLC [10,11,12,13,14]. …”

Section: Introductionmentioning

confidence: 99%

Pretherapeutic Inflammation Predicts Febrile Neutropenia and Reduced Progression-Free Survival after First-Line Chemotherapy in SCLC

Kauffmann-Guerrero¹,

Kahnert²,

Syunyaeva³

et al. 2018

Oncol Res Treat

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Background: Despite initial response to chemotherapy, the prognosis of small cell lung cancer (SCLC) patients is limited. Following first-line therapy, the strongest predictor of durable progression-free survival (PFS) is remission quality. Febrile neutropenia (FN) is a frequent complication after chemotherapy, and its prevention could improve treatment density and degree of remission. Patients and Methods: We retrospectively analyzed 39 SCLC patients treated at a German tertiary care lung cancer center between 2013 and 2016. We extracted data sets from electronic records and analyzed anthropometric data, pretherapeutic blood values, and prognostic scores. Discriminant analysis was performed to predict FN. Results: PFS after first-line chemotherapy was significantly shorter in patients with FN (p = 0.003). Pretherapeutic albumin (p = 0.019), C-reactive protein (CRP; p < 0.001), lactate dehydrogenase (p = 0.041), neutrophil-to-lymphocyte ratio (p = 0.009), prognostic nutritional index (p = 0.018), and Glasgow prognostic score (p < 0.001) were significantly associated with FN. CRP in combination with absolute neutrophil count is a strong predictor of FN (positive predictive value 79.8%). Conclusion: SCLC patients with FN after chemotherapy showed significantly reduced PFS. Prevention of FN may improve treatment results. We identified pretherapeutic markers which can predict FN risk. This simple and cost-effective method could serve to identify the need for preventive measures against FN (e.g., prophylactic antibiotic treatment or granulocyte colony stimulating factor administration).

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“…With regard to lung cancer, the prognostic significance of SII was reported for small cell lung cancer (9) and stage III NSCLC (10). However, to our knowledge, there are no previous studies that evaluated the significance of SII for resectable NSCLC.…”

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confidence: 99%

Systemic Immune-inflammation Index Predicts Survival of Patients After Curative Resection for Non-small Cell Lung Cancer

2018

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Abstract. Background: The systemic immune-inflammation index (SII) is reported to be associated with clinical outcomes and has been proven to be a promising prognostic indicator inCancer-related inflammation is an essential component of the tumor microenvironment, and inflammatory cells may play a critical role in tumor development and progression (1). It has been shown that markers of inflammation and scoring systems based on the systemic inflammatory response are of prognostic value in patients with non-small cell lung cancer (NSCLC) (2). In particular, various combinations of hematological parameters [including C-reactive protein (CRP) concentration, the neutrophil-to-lymphocyte ratio (NLR), and the Glasgow prognostic score (GPS)] have been evaluated as predictors of recurrence or survival in NSCLC (3-6).Recently, a novel index named the systemic immuneinflammation index (SII), based on the peripheral lymphocyte, neutrophil and platelet counts, was investigated as a prognostic marker in several tumor types (7). Geng et al. suggested that SII was superior to other such indices, such as NLR, and served as a more objective marker that reflects the balance between host inflammatory and immune response status in patients with esophageal squamous cell carcinoma (8).With regard to lung cancer, the prognostic significance of SII was reported for small cell lung cancer (9) and stage III NSCLC (10). However, to our knowledge, there are no previous studies that evaluated the significance of SII for resectable NSCLC. Therefore, in the present study, we examined the prognostic significance of SII in patients with resectable NSCLC. Patients and MethodsThis retrospective study was approved by our Institutional Review Board (O-0255) and the need to obtain patient consent was waived. We retrospectively reviewed data from 341 patients (with 173 men and 168 women, median age of 69 years) who underwent complete resection for NSCLC at our hospital from January 2008 to December 2012. The inclusion criteria were as follows: histologically confirmed NSCLC and complete clinical, laboratory, imaging and follow-up data. The exclusion criteria included: preoperative chemotherapy/radiotherapy or death during the 663

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Systemic Immune-inflammation Index, Based on Platelet Counts and Neutrophil-Lymphocyte Ratio, Is Useful for Predicting Prognosis in Small Cell Lung Cancer

Cited by 271 publications

References 39 publications

Relationship between CRP, systemic immune-inflammation index and routine hemogram related inflammatory markers in low grade inflammation

Relationship between CRP, systemic immune-inflammation index and routine hemogram related inflammatory markers in low grade inflammation

Pretherapeutic Inflammation Predicts Febrile Neutropenia and Reduced Progression-Free Survival after First-Line Chemotherapy in SCLC

Systemic Immune-inflammation Index Predicts Survival of Patients After Curative Resection for Non-small Cell Lung Cancer

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