Systemic immune‐inflammation index could estimate the cross‐sectional high activity and the poor outcomes in immunosuppressive drug‐naïve patients with antineutrophil cytoplasmic antibody‐associated vasculitis

Kim, You-Hyun; Choi, Hyang Suk; Jung, Seung Min; Song, Jason Jungsik; Park, Yong Bum; Lee, Sang Won

doi:10.1111/nep.13491

Cited by 52 publications

(40 citation statements)

References 25 publications

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“…In a study of Guo et al, the optimal cutoff values for the prediction of survival were 419.6 for the SII in lung cancer patients [ 33 ]. Kim et al, calculated the optimal cut-off of SII at diagnosis using AUROC (area 0.696, 95% confidence interval (CI) 0.612, 0.781), and found that 1,573.56 of SII was a strongest value for poor outcome [ 14 ].…”

Section: Discussionmentioning

confidence: 99%

“…SII, which is positively correlated with neutrophil, platelet counts and inversely correlated with lymphocyte count, was first developed by Hu et al in 2014 [ 11 ]. Later, several studies also evaluated its prognostic values in various tumors, such as renal cell cancer, lung cancer, prostate cancer and in vasculitis [ 12 – 14 ]. Thus, the aim of our study was to evaluate the role of SII at admission in predicting in-hospital mortality and characterize the factors that trigger unfavorable outcomes in IE.…”

Section: Introductionmentioning

confidence: 99%

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Systemic immune-inflammation index predicts mortality in infective endocarditis

Ağuş

Kahraman

Arslan

et al. 2020

Journal of the Saudi Heart Association

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Objectives The aim of our study was to evaluate the usefulness of systemic immune-inflammation index (SII) at admission in predicting in-hospital mortality in patients with infective endocarditis. Methods 133 definite IE patients (≥18 years) according to modified Duke criteria, treated in our tertiary care hospital between December 2009 and May 2019, were retrospectively analysed. Symptoms, comorbidities, predisposing valvular diseases, prosthetic valve, device, history of injectable drug use, blood culture results, echocardiography findings, and complications were collected. We calculated the SII as follows: SII = platelet count × neutrophil count/lymphocyte count at admission. Results The median age of the patients was 56 (40–66) years. Prosthetic valve disease was the most frequent predisposing valve lesion. Staphylococcus species were the most common microorganisms. The most frequent complication was in-hospital mortality (22%) followed by renal failure. Older population, syncope, increased inflammatory markers, high systolic pulmonary artery pressure (PAPs), heart failure, renal failure, and septic shock were associated with high mortality. However age, syncope, hypocalcemia, not going to surgery, and SII were independent predictors of in-hospital mortality. According to receiver operating characteristic curve analysis, the optimal SII cut-off value for predicting mortality was 2314 (area under the curve 0.641; P = 0.019). Conclusion We demonstrated that high SII levels are independently associated with in-hospital mortality. The SII may be a promising prognostic predictor for patients with infective endocarditis.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Systemic immune-inflammation index predicts mortality in infective endocarditis

Ağuş

Kahraman

Arslan

et al. 2020

Journal of the Saudi Heart Association

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“…Other predictive factors included the presence of CRP and ANC. Derived indexes, such as NLR [36,37] and SII [38] have previously been used as prognostic markers for other inflammatory and autoimmune conditions, as well as in the context of malignant disease, and were also associated with an increased risk of relapse. In our study population, ulceration at presentation was the strongest predictor of recurrence (OR 18.6), and elevated pre‐treatment values of ESR, CPR, ANC, NLR and SII were also associated with a poor prognosis in terms of recurrence.…”

Section: Discussionmentioning

confidence: 99%

Manifestations, clinical course and prognostic markers in cutaneous polyarteritis nodosa

Munera‐Campos

Bielsa

Martínez-Morillo

et al. 2020

J Deutsche Derma Gesell

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Summary Background and objectives Cutaneous polyarteritis nodosa (CPAN) is a comparatively rare form of vasculitis that affects small arteries and arterioles in the panniculus and dermo‐subcutaneous junction. Limited information is available regarding its course in the European population. The aim of this study is to characterize the manifestations and prognostic markers of recurrence in CPAN. Patients and methods We report a retrospective study of patients with clinical and histopathologic evidence of CPAN, which was treated at two tertiary referral centers in Spain between 1989 and 2019. Results 31 patients were included. The most frequent manifestation was subcutaneous nodules (90.3 %); ulcers were frequent at diagnosis (35.5 %). Two thirds of the patients had at least one extracutaneous manifestation. Seventeen patients (54.8 %) experienced relapse. The strongest predictor of recurrence was ulceration in the initial episode (OR 18.6; 95 % CI 2.73–38; p < 0.01). The pre‐treatment results of laboratory parameters associated with inflammation (such as C‐reactive protein and neutrophil‐to‐lymphocyte ratio) were significantly higher in the relapsing group. There were no disease‐related deaths and none of the patients developed systemic PAN. Conclusions Although CPAN is a vasculitis limited to the skin, symptoms may involve adjacent skeletal muscle or peripheral nerves. While the condition is not life‐threatening, the presence of ulceration and elevation of certain laboratory parameters predicts a worse prognosis.

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“…Weitere prädiktive Faktoren waren CRP und ANC. Abgeleitete Indizes wie NLR [36,37] und SII [38] wurden früher als prognostische Marker für andere Entzündungs‐ und Autoimmunkrankheiten sowie im Zusammenhang mit malignen Erkrankungen verwendet und waren ebenfalls mit einem erhöhten Rückfallrisiko verbunden. In unserer Studienpopulation waren Ulzerationen bei der Vorstellung der stärkste Prädiktor für ein Rezidiv (OR 18,6), und erhöhte Werte von ESR, CPR, ANC, NLR und SII vor der Behandlung waren ebenfalls mit einer schlechten Prognose hinsichtlich eines Rezidivs verbunden.…”

Section: Diskussionunclassified

Manifestationen, Krankheitsverlauf und prognostische Parameter bei kutaner Polyarteriitis nodosa

Munera‐Campos

Bielsa

Martínez-Morillo

et al. 2020

J Deutsche Derma Gesell

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Hintergrund und Ziele: Die kutane Polyarteriitis nodosa (CPAN) ist eine relativ seltene Vaskulitis, die kleine Arterien und Arteriolen im Unterhautfettgewebe und in der dermo-subkutanen Übergangszone befällt. Über ihren Verlauf liegen für die europäische Bevölkerung nur wenige Daten vor. Ziel dieser Studie ist es, Manifestationen und Prognoseparameter für ein Rezidiv bei CPAN zu beschreiben. Patienten und Methoden: Wir stellen eine retrospektive Studie an Patienten mit klinischer und histologischer Evidenz für CPAN vor, die zwischen 1989 und 2019 in zwei tertiären Referenzzentren in Spanien behandelt wurden. Ergebnisse: Eingeschlossen waren 31 Patienten. Die häufigste Manifestation waren subkutane Knoten (90,3 %). Zum Zeitpunkt der Diagnose traten häufig Ulzera auf (35,5 %). Bei zwei Dritteln der Patienten lag mindestens eine extrakutane Manifestation vor. Siebzehn Patienten (54,8 %) erlitten ein Rezidiv. Der stärkste Prädiktor für ein Rezidiv waren Ulzerationen in der ersten Episode (OR 18,6; 95%-KI 2,73-38; p < 0,01). Entzündungsassoziierte Laborparameter (wie C-reaktives Protein und Neutrophilen/ Lymphozyten-Verhältnis) vor der Behandlung waren bei der Gruppe mit Rezidiv signifikant höher. Krankheitsbedingte Todesfälle traten nicht auf und kein Patient entwickelte eine systemische PAN. Schlussfolgerung: CPAN ist eine auf die Haut begrenzte Vaskulitis. Jedoch können die Symptome auf benachbarte Skelettmuskeln oder periphere Nerven übergreifen. Die Krankheit ist nicht lebensbedrohlich, jedoch sind Ulzerationen und der Anstieg bestimmter Laborparameter mit einer schlechten Prognose assoziiert.

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Systemic immune‐inflammation index could estimate the cross‐sectional high activity and the poor outcomes in immunosuppressive drug‐naïve patients with antineutrophil cytoplasmic antibody‐associated vasculitis

Abstract: SII at diagnosis could estimate the cross-section severe AAV and predict the poor outcomes in AAV patients. This article is protected by copyright. All rights reserved.

Cited by 52 publications

References 25 publications

Systemic immune-inflammation index predicts mortality in infective endocarditis

Systemic immune-inflammation index predicts mortality in infective endocarditis

Manifestations, clinical course and prognostic markers in cutaneous polyarteritis nodosa

Manifestationen, Krankheitsverlauf und prognostische Parameter bei kutaner Polyarteriitis nodosa

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