Systemic Immune-Inflammation Index for Predicting the Prognosis of Critically Ill Patients with Acute Pancreatitis

Abstract

Background Systemic immune-inflammation index (SII) has been identified as a prognostic biomarker in various diseases. However, its significance in acute pancreatitis (AP) has not been reported. Therefore, the main aim of this study was to determine the association of SII with clinical outcomes of AP patients, after adjusting for several confounders. Methods This retrospective cohort study was conducted using data retrieved from the Medical Information Mart for Intensive Care III database (MIMIC-III). The study only included patients diagnosed with AP. SII was calculated as the platelet counts x neutrophil counts/lymphocyte counts. Cox regression models were employed to assess the impact of SII on the 30- and 90-day mortality of AP patients. Subgroup analysis was carried out to explore the stability of the relationship between SII and AP mortality. Results A total of 513 patients were found to be eligible based on the inclusion and exclusion criteria. For 30-day all-cause mortality, in the model adjusted for multiple confounders, the HR (95% CI) for mid-SII group (SII: 75.6−104.2) and high-SII groups (SII: >104.2) were 1.29 (0.65, 2.56) and 2.57 (1.35, 4.88), respectively, compared to the low-SII group (SII: <75.5). A similar trend was observed for 90-day mortality. Subgroup analyses presented a stable relationship between SII and 30-day all-cause mortality of AP patients. Conclusion SII is a potentially useful prognostic biomarker for AP. However, prospective studies are needed to confirm this finding.

Unraveling the clinical significance and prognostic value of the neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, systemic immune-inflammation index, systemic inflammation response index, and delta neutrophil index

“…In a retrospective study with 513 patients with pancreatitis, the high SII group (>755 × 10 9 /L) had a significantly higher rate of 30-day all-cause mortality (HR = 2.57; 95% CI = 1.35–4.88). [ 114 ] The study did not examine the utility of SII in predicting severe acute pancreatitis or in-hospital mortality.…”

Immune-Related Genes can Serve as Potential Biomarkers for Predicting Severe Acute Pancreatitis

“…Although the severity of AP can be clinically assessed through multifactor scoring systems and imaging studies, the emergence of biomarkers and predictive models provide another effective method for the diagnosis of patients with AP [46]. Previous study indicated that the systemic immune inflammatory index could comprehensively reflect the disease characteristics of AP [47]. Thus, we screened for biomarkers that could predict AP severity based on immune-related genes.…”

Systemic immune-inflammation index may predict the acute kidney injury and prognosis in patients with spontaneous cerebral hemorrhage undergoing craniotomy: a single-center retrospective study

“…The SII was initially developed to reflect the balance of host inflammatory and immune status, which could predict the outcome in patients with hepatocellular carcinoma [ 5 ]. Recently, it has been investigated as a prognostic factor for various cancers [ 6 , 7 ], inflammatory status [ 8 , 9 ], and coronary disease [ 10 ]. The systemic inflammation response index (SIRI), which is also calculated from peripheral blood cells, has similar characteristics to those of the SII [ 8 , 9 ].…”

“…Recently, it has been investigated as a prognostic factor for various cancers [ 6 , 7 ], inflammatory status [ 8 , 9 ], and coronary disease [ 10 ]. The systemic inflammation response index (SIRI), which is also calculated from peripheral blood cells, has similar characteristics to those of the SII [ 8 , 9 ].…”