Systemic immune inflammation index in differentiated thyroid cancers

Kars, Ayhan; Şahin, Abdulkadir; Kılıç, Korhan; Sakat, Muhammed Sedat; Bilen, Arzu

doi:10.14639/0392-100x-n1665

Cited by 11 publications

(6 citation statements)

References 20 publications

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“…It was first described as an indicator of prognosis in patients with resected hepatocellular carcinoma [9]. Subsequently, SII was shown to have prognostic value for various cancers [15][16][17][18][19][20][21][22]. Previous studies in adult patients with sepsis are consistent with our results [23,24].…”

Section: Discussionsupporting

confidence: 89%

Association between admission systemic immune-inflammation index and mortality in critically ill patients with sepsis: a retrospective cohort study based on MIMIC-IV database

et al. 2023

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Systemic immune-inflammation index (SII) has been identified as a prognostic biomarker for various diseases. Our study aimed to investigate the association between SII and mortality risk in critically ill patients with sepsis, thus exploring possible tools for rapid screening. This retrospective cohort study was conducted using clinical data extracted from the Medical Information Mart for Intensive Care Database. The study included only patients diagnosed with sepsis admitted to the intensive care unit for the first time. We used the restricted cubic splines to explore the relationship between SII and 28-day mortality. Kaplan-Meier curve and Cox regression models were performed to evaluate the association between SII and mortality. Subgroup analysis was performed to explore the stability of the primary results. A total of 16,007 patients with sepsis were eligible in the final analysis. We found a J-shaped relationship between SII and mortality risk. The SII level associated with the lowest mortality risk was 774.46*10 9 /L. Compared with the reference group (second SII quartile), the 28-day mortality was increased in the highest quartile and third quartile groups of SII levels; fully adjusted HRs were 1.16 (1.02 to 1.32) and 1.40 (1.23 to 1.58), respectively. However, although the lower SII (Q1 group) also showed a trend toward a higher hazard of 28-day mortality, there was no statistical difference, with a fully adjusted HR of 1.05 (0.92 to 1.21). In the population of critically ill patients with sepsis, low and high SII levels were associated with an increased risk of short-term mortality. The 28-day mortality risk was lowest at SII levels of 774.46*10 9 /L.

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Section: Discussionsupporting

confidence: 89%

Association between admission systemic immune-inflammation index and mortality in critically ill patients with sepsis: a retrospective cohort study based on MIMIC-IV database

et al. 2023

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“…The SII, another prognostic marker, was found to be higher in patients with thyroid cancer compared to healthy individuals in a study, but no correlation was found between lymph node involvement, invasion, and tumor size. [ 30 ] However, in another study, a relationship was found between lymph node involvement and SII. [ 31 ] In our study, no significant relationship was found between SII and tumor size, metastasis, and invasion in thyroid cancer patients.…”

Section: Discussionmentioning

confidence: 98%

Evaluation of the clinical and prognostic importance of infection parameters in thyroid cancers: A cross-sectional study

Ecin,

Gezer

2023

Medicine

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Thyroid cancers are among the most common endocrine cancers. An inflammation is associated with many stages of cancer. Therefore, in this study, we aimed to evaluate whether it has a prognostic significance inflammation marker. Neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, monocyte/lymphocyte ratio, systemic inflammation response, systemic immune-inflammation index, and neutrophils to lymphocytes and platelets ratio (N/LP) in patients diagnosed with thyroid cancer in the internal medicine outpatient clinic and operated between March 1, 2017 and May 1, 2022 were evaluated retrospectively. Three hundred forty patients were diagnosed with thyroid cancer; 275 (80.9%) of them were women and the mean age was 44.6 ± 13.5 years. Multifocality (P = .02) was significant in patients with invasion. High N/LP ratio (odds ratio: 1.4, 95% confidence interval: 1.0–2.0, p: 0.003) and high invasion (odds ratio: 0.2, 95% confidence interval: 0.1–0.4, P < .01) was found to be significant in patients with tumor size ≥2 cm. There is a relationship between multifocality and invasion, and the risk of invasion increases as the tumor size increases in thyroid cancer. The N/LP ratio was significant as it could be a new marker in showing the relationship between thyroid cancer and its prognosis. Further studies are needed in which the prognosis is followed up, longer-term, more comprehensive, and confounding factors are excluded.

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“…Systemic immune-inflammation index (SII) is a composite index based on the absolute counts of neutrophils, lymphocytes, and platelets and has been found to be associated with the prognosis of several cancers. In a previous study, it was observed that the SII of patients with differentiated thyroid cancer was significantly higher when compared to a control group (6). Similarly, in a recent study, it has been reported that elevated neutrophil-lymphocyte ratio (NLR) values in patients with nodules can predict malignancy 11 .…”

Section: Introductionmentioning

confidence: 88%

“…In recent years, the hematological parameters have gained attention as potential markers to enhance the diagnosis and prognosis of various inflammatory conditions, including cancers [5][6][7][8][9][10][11][12] . Systemic immune-inflammation index (SII) is a composite index based on the absolute counts of neutrophils, lymphocytes, and platelets and has been found to be associated with the prognosis of several cancers.…”

Section: Introductionmentioning

confidence: 99%

Evaluación de los parámetros inflamatorios como marcadores predictivos de malignidad en nódulos tiroideos: un estudio sobre su correlación con la clasificación de Bethesda

Óenoymak,

BaÓ,

Yeniçeri

et al. 2024

CIRU

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Objective:The study aimed to assess the predictive significance of inflammatory parameters as potential markers for malignancy in individuals with thyroid nodules. Method: Nine hundred and ninety-one patients with thyroid nodules who had undergone thyroid fine-needle aspiration biopsy were included and classified according to the Bethesda system. Neutrophil lymphocyte ratio (NLR) and systemic immune-inflammation index (SII) values obtained from hemogram parameters were determined for each patient. The study examined the correlation between the Bethesda classification and NLR/SII levels. In addition, a comparison was made between the inflammatory parameters of the benign and malignant Bethesda groups. Results: Five hundred and seventy-three patients were classified as Bethesda 2 (benign), 34 as Bethesda 6 (malignant). A correlation was observed between the Bethesda classification and NLR and SII levels (r: 0.230, p < 0.001; r: 0.207 p < 0.001, respectively). NLR and SII values were significantly higher in the malignant group (p < 0.001). The cutoff value for SII in predicting benign and malignant thyroid nodules was 489.86 × 10 3 /mm 3 with a sensitivity of 88.2% and a specificity of 63.7%. The cutoff value for NLR for the same prediction was 2.06 with a sensitivity of 82.4% and a specificity of 83.4%. Conclusions: The findings of this study indicate that SII and NLR may be valuable prognostic markers for predicting the malignancy of thyroid nodules.

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Systemic immune inflammation index in differentiated thyroid cancers

Cited by 11 publications

References 20 publications

Association between admission systemic immune-inflammation index and mortality in critically ill patients with sepsis: a retrospective cohort study based on MIMIC-IV database

Association between admission systemic immune-inflammation index and mortality in critically ill patients with sepsis: a retrospective cohort study based on MIMIC-IV database

Evaluation of the clinical and prognostic importance of infection parameters in thyroid cancers: A cross-sectional study

Evaluación de los parámetros inflamatorios como marcadores predictivos de malignidad en nódulos tiroideos: un estudio sobre su correlación con la clasificación de Bethesda

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