Systemic inflammatory autoimmune disease before allogeneic hematopoietic stem cell transplantation is a risk factor for death in patients with myelodysplastic syndrome or chronic myelomonocytic leukemia

Myelodysplastic syndrome (MDS) is a clonal disorder that affects hematopoietic stem cells (HSCs), primarily occurring in the elderly population. Lower-risk MDS is characterized by a decrease in blood cells, whereas higher-risk MDS is associated with an increased risk of transformation to acute myeloid leukemia (AML). Currently, the treatment of MDS is still unsatisfactory, although demethylating agents, azacitidine (AZA), and decitabine (Dec) have been successfully used to treat MDS and improve survival rates. However, hematopoietic stem cell transplantation (HSCT) remains the only curative treatment for MDS patients, effectively increasing patient survival and quality of life. Nevertheless, treatment-related toxicity, graft-versus-host disease, infectious complications, and relapse are still major post-transplant issues. In this review, through a retrospective analysis of past and present HSCT for the treatment of MDS, we provide insights for the future.

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The causal effect of autoimmune diseases on myelodysplastic syndrome:a Mendelian randomization study

Miao,

Zhu,

Zhou

et al. 2024

Preprint

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Background The relationship between different types of autoimmune diseases and myelodysplastic syndrome (MDS) are inconclusive. Therefore,we employed Mendelian randomization (MR) to explore the causal associations between autoimmune diseases and MDS. Methods Single nucleotide polymorphisms (SNPs) significantly associated with 10 autoimmune diseases were extracted from the summary statistics of European genome-wide association studies (GWAS). A two-sample MR analysis was performed using summary-level statistics sourced from GWAS datasets. Inverse-variance weighting (IVW),MR‒Egger,and weighted median (WM) were further supported by several sensitivity analyses. Results Four autoimmune diseases showed genetical predisposition to MDS: rheumatoid arthritis(OR = 1.186,95%CI = 1.028–1.367, P = 0.019), multiple sclerosis(OR = 1.247,95%CI = 1.013–1.534, P = 0.037), myasthenia gravis(OR = 1.326,95%CI = 1.010–1.742, P = 0.042), and hashimoto thyroiditis(OR = 1.519,95%CI = 1.008–2.290, P = 0.046).Nevertheless,no similar causal relationship was found between the remaining seven autoimmune diseases and MDS.The accuracy and robustness of these findings were confirmed by sensitivity tests. Conclusions We are the first to use MR analysis to explore the causal relationships between autoimmune diseases and MDS.The mechanism of this causal link needs to be further explored.

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Systemic inflammatory autoimmune disease before allogeneic hematopoietic stem cell transplantation is a risk factor for death in patients with myelodysplastic syndrome or chronic myelomonocytic leukemia

Cited by 3 publications

References 49 publications

Association between autoimmune diseases and myelodysplastic syndrome:a Mendelian randomization study

Association between autoimmune diseases and myelodysplastic syndrome:a Mendelian randomization study

Hematopoietic Stem Cell Transplantation in the Management of Myelodysplastic Syndrome: A Retrospective, Current, and Future Perspective

The causal effect of autoimmune diseases on myelodysplastic syndrome:a Mendelian randomization study

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