Systemic inflammatory response markers in preeclampsia

Abstract

PURPOSE:Neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), platelet distribution width (PDW), red cell distribution width (RDW), mean platelet volume (MPV), and plateletcrit (PCT) are known as systemic inflammatory response markers. In this study, we aimed to evaluate changes in NLR, PLR, PDW, RDW, MPV, and PCT in preeclampsia (PE) and their use in predicting its severity.MATERIALS AND METHODS:This is a retrospective case–control study. The study comprised 64 control group (healthy pregnant females), 51 females with mild PE, and 13 with severe PE. These three groups were compared with demographic data and inflammation markers.RESULTS:There were no statistically significant differences between healthy pregnant females and preeclaptic females in terms of median age, hemoglobin, lymphocyte, neutrophil, platelet, NLR, PLR, PDV, RDW, MPV, PCT (P > 0.05). The control group has a higher number of gravity and parity than the PE group (P < 0.001). MPV value is a lower PE group than the control group (P < 0.001). Both gravity and parity were significantly higher in the patients with mild PE than in the control group (P < 0.001). MPV value was statistically higher in the control group compared both mild and severe PE (P < 0.001), however, no statistical difference between mild and severe PE (P = 0.305).CONCLUSIONS:MPV may be clinically useful markers in the prediction of PE. Further, prospective multicenter studies are needed to reveal the association between these markers and PE.

Neutrophil-to-Lymphocyte Ratio, Platelet-to-Lymphocyte Ratio, and Routine Complete Blood Count Components in HELLP Syndrome: A Matched Case Control Study

“…The association between NLR/PLR and preeclampsia produced mixed results in previous studies [11,12,13].…”

“…Cintesun et al, in 2018, did not find any statistically significant difference regarding NLR and PLR between 64 patients with preeclampsia and 66 women with healthy pregnancies in the third trimester [13].…”

“…An increase in neutrophils and a decrease in lymphocytes resulted in an increased neutrophil-to-lymphocyte ratio (NLR) in preeclampsia [11,12] in most, but not all, available studies [13]. The lower number of lymphocytes and the higher number of platelets led to an increased platelet-to-lymphocyte ratio (PLR) in some studies, whereas, in other studies, the PLR did not differ between cases and controls [13,14,15].…”

Inflammatory events in patients with sagittal imbalance through platelet-associated inflammation

“…This also led to a search for novel useful markers similar to CRP. Recent studies have shown platelets to be the most important potential inflammatory candidates and changing values could be useful to demonstrate events of SI (2,30). Therefore, platelet-related parameters were analysed in this study in addition to CPR and ESR.…”

“…Evaluation of the inflammatory condition may allow important predictions of the effectiveness of the surgical procedure and postoperative recovery (28). Recent studies have shown a significant relationship between platelets and inflammatory events in several diseases (2,17,23,30). Therefore, it can be considered that novel platelet-associated inflammation parameters (PAIP) such as Platelet Distribution Width (PDW), Mean Platelet Volume (MPV), Platelet-to-Lymphocyte Ratio (PLR) and Neutrophil-to-Lymphocyte Ratio (NLR) could provide information about inflammatory events.…”