Systemic Inflammatory Response to Malaria During Pregnancy Is Associated With Pregnancy Loss and Preterm Delivery

Fried, Michal; Kurtis, Jonathan D.; Swihart, Bruce J.; Pond-Tor, Sunthorn; Barry, Amadou; Sidibé, Yoro; Gaoussou, Santara; Traoré, Moussa; Kéita, S.; Mahamar, Almahamoudou; Attaher, Oumar; Dembelé, Adama; Cisse, Kadidia B.; Diarra, Bacary S; Kanoute, Moussa B.; Dicko, Alassane; Duffy, Patrick E.

doi:10.1093/cid/cix623

Cited by 52 publications

(56 citation statements)

References 35 publications

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“…A study by Choi and colleagues (Choi et al, 2016) showed that maternal immune activation increases maternal IL-17a levels, which induces an autism spectrum-like phenotype and brain development abnormalities in offsprings. Other studies have also shown a correlation between poor pregnancy outcomes and the concentrations of systemic cytokines, including TNF-α, IFNγ, and IL-10 in women with malaria (Fried et al, 2017). Abnormally elevated levels of TNF-α in the maternal peripheral blood can be toxic to early embryo development, induces preterm labor in non-human primate models, and mediates fetal demise in mouse models of LPS and poly(I:C)-induced fetal resorption (Yockey et al, 2018).…”

Section: The Role Of Maternal Immune Responses To Covid-19mentioning

confidence: 99%

Why are pregnant women susceptible to COVID-19? An immunological viewpoint

Liu

Wang

Zhao

et al. 2020

Journal of Reproductive Immunology

472

427

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Section: The Role Of Maternal Immune Responses To Covid-19mentioning

confidence: 99%

Why are pregnant women susceptible to COVID-19? An immunological viewpoint

Liu

Wang

Zhao

et al. 2020

Journal of Reproductive Immunology

472

427

View full text Add to dashboard Cite

“…14,29 The high level of TNF-α during early pregnancy is associated with defects in early embryo development 30 pregnancy-related complications upon malaria infection. 31 A recent systematic review identified increased level of C-reactive protein (CRP) in a majority of COVID-19 positive pregnant women. 20 Taken together, the cytokine storm (pro-inflammatory cytokines) induced by SARS-CoV-2 might place pregnant women at greater risk by causing an increased pro-inflammatory state with the potential to impact fetal brain development; thus, increasing the risk for autism, mental health disorders or schizophrenia.…”

Section: Immunology Of Covid-19 In Pregnancymentioning

confidence: 99%

SARS‐CoV2 and pregnancy: An invisible enemy?

Verma

Carter

Mysorekar

2020

American J Rep Immunol

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Coronavirus disease 2019 or COVID-19 is an emerging viral disease caused by a member of the betacoronavirus family, SARS-CoV-2. Since its' emergence in December 2019, it has rapidly caused close to half a million fatalities globally. Data regarding the impact of COVID-19 on pregnancy are limited. Here, we review pathological findings in placentas from women who tested positive for SARS-CoV-2 as well as information on pregnancy outcomes associated with related and highly pathogenic coronaviruses (ie, severe acute respiratory syndrome (SARS-COV) and the Middle East respiratory syndrome, MERS). We present immune-inflammatory correlates of COVID-19 in pregnancy and review the role of the Renin Angiotensin System in the pathogenesis of COVID-19 in pregnancy. Greater understanding of the pathogenesis of SARS-CoV-2 in the placenta will yield important insight into potential therapeutic interventions for pregnant women with COVID-19.

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“…5,52 In women with PM, levels of cytokines and chemokines including CXCL9, IFNγ, IL-10, and IL-1β have been associated with poor pregnancy outcomes including fetal loss, low birthweight, and preterm delivery. 53 It is likely that transfer of immune-modulating factors into the fetal circulation may have additional, currently unknown, influences on fetal immune development.…”

Section: Mal Aria Anti G En E Xp Osure I N Uteromentioning

confidence: 99%

The immune response to malaria in utero

Feeney

2019

Immunological Reviews

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Malaria caused by Plasmodium falciparum is a leading killer of infants and children. Efforts to develop a protective vaccine have been hindered by the parasite's numerous evasion strategies, which include the induction of immunoregulatory mechanisms in the human host.Indeed, several promising vaccine candidates that induce robust protection in malaria-naive populations have been shown to have much lower efficacy when administered to individuals residing in endemic settings, 1,2 suggesting that immunomodulatory mechanisms induced by prior malaria exposure may pose a critical barrier to vaccine-mediated protection. In endemic regions, many individuals are first exposed to malaria in utero, when P. falciparum-infected red blood cells sequester in the placenta and parasite antigens cross the syncytiotrophoblast barrier, gaining entry into the fetal circulation.Therefore, even during the neonatal period, vaccination may be influenced by prior malaria exposure. Here, we examine the consequences of in utero antigen exposure for fetal immune development and postnatal immunity. The worldwide burden posed by malaria-related complications of pregnancy is profound. More than 125 million pregnancies occur annually in regions at risk for malaria transmission, 3 and one in four pregnant women in sub-Saharan Africa have evidence of infection with malaria at parturition. 4 Although most placental malaria (PM) infections are attributable to P. falciparum, recent evidence indicates that P.vivax is also associated with poor pregnancy outcomes, and some data suggest that it too may sequester in the placenta. 5,6 Pregnancy-associated malaria results in tremendous obstetrical and pediatric morbidity, AbstractMalaria causes tremendous early childhood morbidity and mortality, providing an urgent impetus for the development of a vaccine that is effective in neonates. However, the infant immune response to malaria may be influenced by events that occur well before birth. Placental malaria infection complicates one quarter of all pregnancies in Africa and frequently results in exposure of the fetus to malaria antigens in utero, while the immune system is still developing. Some data suggest that in utero exposure to malaria may induce immunologic tolerance that interferes with the development of protective immunity during childhood. More recently, however, a growing body of evidence suggests that fetal malaria exposure can prime highly functional malariaspecific T-and B-cells, which may contribute to postnatal protection from malaria. In utero exposure to malaria also impacts the activation and maturation of fetal antigen presenting cells and innate lymphocytes, which could have implications for global immunity in the infant. Here, we review recent advances in our understanding of how various components of the fetal immune system are altered by in utero exposure to malaria, discuss factors that may tilt the critical balance between tolerance and adaptive immunity, and consider the implications of these findings for malaria prevention strateg...

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Systemic Inflammatory Response to Malaria During Pregnancy Is Associated With Pregnancy Loss and Preterm Delivery

Abstract: NCT01168271.

Cited by 52 publications

References 35 publications

Why are pregnant women susceptible to COVID-19? An immunological viewpoint

Why are pregnant women susceptible to COVID-19? An immunological viewpoint

SARS‐CoV2 and pregnancy: An invisible enemy?

The immune response to malaria in utero

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