“…On post-mortem examination, fish infected with megalocytiviruses may exhibit hemorrhagic lesions, renomegaly, spleno megaly, hepa tomegaly, and coelomic distension resul ting from hemorrhagic fluid accumulation , Weber et al 2009, Yanong & Waltzek 2010, Wang et al 2011, Zhang et al 2011, Waltzek et al 2012. Histo pathologic examination typically reveals cyto megalic mesenchymal cells characterized by strongly basophilic or amphophilic granular intracytoplasmic inclusions observed in multiple organs including the spleen, kidney, liver, heart, brain, gills, intestine, eyes, and gonads , Gibson-Kueh et al 2003, Weber et al 2009, Yanong & Waltzek 2010, Zhang et al 2011, Waltzek et al 2012. Transmission electron microscopy (TEM) invariably reveals nu me rous icosahedral virus particles with a capsid diameter between 120 and 200 nm in the cytoplasm of infected cells , Weber et al 2009, Yanong & Waltzek 2010, Wang et al 2011, Zhang et al 2011, Kurita & Nakajima 2012, Waltzek et al 2012.…”