Systemic lupus erythematosus and celiac disease

Abdelghani, K. Ben; Mouelhi, Leïla; Hriz, A.; Hajri, S.; Najjar, Taoufik; Mahfoudhi, M.; Turki, S.; Khedher, A.

doi:10.1016/j.jbspin.2011.07.010

Cited by 10 publications

(14 citation statements)

References 10 publications

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“…In 2008, Freeman described 6 individuals with CD who developed SLE (out of 246 individuals with CD seen at the University of British Columbia Hospital during a period of 25 years) 18 . Among 24 patients with SLE screened for CD in Tunisia, Ben Abdelghani, et al found a high prevalence of antigliadin antibodies but also 2 patients (8%) with positive tissue transglutaminase antibodies; of them, CD was confirmed by histopathology in 1 patient (4%) 19 . However, these 3 studies 17,18,19 were performed within patient groups with no general population comparator and none included children.…”

Section: Discussionmentioning

confidence: 99%

“…Several case reports and case series have suggested a possible association between CD and SLE 11,12,13,14,15, 16,17,18,19 , but earlier research has suffered from low statistical power. At least 2 studies have also reported a high prevalence of antigliadin antibodies in SLE but with substantially lower rates of histologically verified CD 17,19 , and because of their lack of a control group with non-SLE individuals, these studies were unable to estimate relative risks of SLE in CD.…”

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confidence: 99%

“…At least 2 studies have also reported a high prevalence of antigliadin antibodies in SLE but with substantially lower rates of histologically verified CD 17,19 , and because of their lack of a control group with non-SLE individuals, these studies were unable to estimate relative risks of SLE in CD. Connective tissue disorders as a group seem to be more frequent among patients with CD, but the small number of cases affected by each specific connective tissue disorder has been a limitation to estimate disease-specific risk 20 .…”

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confidence: 99%

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Increased Risk of Systemic Lupus Erythematosus in 29,000 Patients with Biopsy-verified Celiac Disease

Ludvigsson

Rubio–Tapia²,

Chowdhary³

et al. 2012

J Rheumatol

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Objective To investigate a possible association between celiac disease (CD) and systemic lupus erythematosus (SLE). Case series have indicated a possible association, but population-based studies are lacking. Methods We compared the risk of SLE in 29,048 individuals with biopsy-verified CD (villous atrophy, Marsh 3) from Sweden’s 28 pathology departments with that in 144,352 matched individuals from the general population identified through the Swedish Total Population Register. SLE was defined as having at least 2 records of SLE in the Swedish Patient Register. We used Cox regression to estimate hazard ratios (HR) for SLE. Results During followup, 54 individuals with CD had an incident SLE. This corresponded to an HR of 3.49 (95% CI 2.48–4.90), with an absolute risk of 17/100,000 person-years and an excess risk of 12/100,000. Beyond 5 years of followup, the HR for SLE was 2.54 (95% CI 1.57–4.10). While SLE was predominantly female, we found similar risk estimates in men and women. When we restricted our outcome to individuals who also had a dispensation for a medication used in SLE, the HR was 2.43 (95% CI 1.22–4.87). The HR for having 2 records of SLE diagnoses, out of which at least 1 had occurred in a department of rheumatology, nephrology/dialysis, internal medicine, or pediatrics, was 2.87 (95% CI 1.97–4.17). Conclusion Individuals with CD were at a 3-fold increased risk of SLE compared to the general population. Although this excess risk remained more than 5 years after CD diagnosis, absolute risks were low.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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Increased Risk of Systemic Lupus Erythematosus in 29,000 Patients with Biopsy-verified Celiac Disease

Ludvigsson

Rubio–Tapia²,

Chowdhary³

et al. 2012

J Rheumatol

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“…Although systemic lupus erythematosus (SLE) and celiac disease (CD) might share common genetic features, 1,2 their concomitance was only occasionally presented, mostly as case reports. 3,4 The SLE risk of occurrence appears to be increased three-fold in CD when compared with the general population, but the absolute excess of risk proved to be actually low. 4 In relation to CD serology in lupus, positive anti-deamidated gliadin peptides antibodies (DGPs) seem commonly encountered.…”

Section: Sirmentioning

confidence: 98%

“…Occurrence of both DGP and anti-tissue transglutaminase antibodies (tTGs) was found in 8% of SLE patients. 3 Moreover, anti-endomysium antibodies (EMAs) IgA serotype seem associated with lupus disease. 6 Our aim was to evaluate the gluten-induced immune and autoimmune phenomenon in SLE patients.…”

Section: Sirmentioning

confidence: 99%