Systemic Lupus Erythematosus Presenting as Acute Lupus Pneumonitis

Lazović, Biljana; Zlatković-Švenda, Mirjana; Jašarović, Damir; Stevanović, Dejan

doi:10.1016/j.arbr.2017.08.018

Cited by 3 publications

(3 citation statements)

References 5 publications

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“…Uniquely, our patient presented with acute lupus pneumonitis (ALP). ALP is a rare SLE complication that affects around 2% of these patients [ 2 , 3 ]. It presents with fever, cough, dyspnea, and hypoxemia in a patient with suggestive symptoms of lupus such as arthralgias, fatigue, and malar rash.…”

Section: Discussionmentioning

confidence: 99%

Systemic Lupus Erythematosus Presenting as Acute Lupus Pneumonitis during Pregnancy

Furment

Sharma

Pabolu

2020

Case Reports in Rheumatology

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Introduction. This is a case of new-onset systemic lupus erythematosus (SLE) manifesting as acute pneumonitis during pregnancy. No prior reports have documented pneumonitis as the presenting manifestation of SLE in pregnant women. Case Presentation. A 23-year-old pregnant female presented with high-grade fever, cough, arthralgias, and respiratory failure. Infectious workup was negative. She was positive for ANA, anti-dsDNA, anti-SSA, hypocomplementemia, and pulmonary infiltrates, supporting the diagnosis of SLE and pneumonitis. The patient received methylprednisolone achieving adequate clinical and serological response. Conclusion. When SLE patients present with fever, cough, and respiratory failure, pulmonary infiltrates should raise the suspicion of pneumonitis in the absence of infection and hemorrhage. Even though acute lupus pneumonitis (ALP) is rare and seen only in 2% of SLE patients, a high index of suspicion aids in prompt diagnosis of this life-threatening condition. Also, positive anti-SSA antibodies may be associated with lupus pneumonitis.

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Section: Discussionmentioning

confidence: 99%

Systemic Lupus Erythematosus Presenting as Acute Lupus Pneumonitis during Pregnancy

Furment

Sharma

Pabolu

2020

Case Reports in Rheumatology

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“…Antiphospholipid syndrome (APS)or Hughes Syndrome is an autoimmune disordercaused by the blood clots forming increased risk accompanied by one of antiphospholipid antibodies (APL): anticardiolipin antibodies (aCLA), anti-beta2-glycoprotein (GP1) antibodies and/or lupus anticoagulant (LA), registered in two or more occasions 12 weeks apart, resulting inarterial/venous thrombosis and/or fetal loss (1,2). APS can be primary-not accompanied by other autoimmune disorders and secondary-connected with mixed connective tissue disease, such as the systemic lupus erythematosus is (2,3).…”

Section: Introductionmentioning

confidence: 99%

Secondary antiphospholipid syndrome revealed by the sudden onset of pneumonia: Case report

Lazović

Zlatković-Švenda

Blažić

et al. 2019

Sanamed

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Introduction: Secondary antiphospholipid syndrome (SAPS) is APS that occurs in the context of another medical condition. Although antiphospholipid antibodies (aPL) can occur in patients with viral, bacterial, or protozoal infections, they are rarely associated with thrombosis.Aim: To present an uncommon case of pneumonia and pleural effusion complicated with pulmonary thromboembolism in a patient with systemic lupus erythematosus (SLE), due to non-diagnosed secondary antiphospholipid syndrome.Case report: A 28 years old woman, never pregnant, with a family history of systemic lupus erythematosus, has been suffering from SLE from the age of 18. She had only articular and skin manifestations, without internal organ involvement. She has been taking Methotrexate (10 mg weekly) and Prednisone (5 mg daily) in the previous 10 years. She was presented at the Emergency department with the radiological finding of pleuropneumonia followed by temperature up to 39C, shortness of breath, cough, fatigue, and weakness.Results: She was treated initially with three antibiotics and thoracocentesis. She developed pulmonary thrombosis without deep venous thrombosis. Laboratory findings were: ESR = 37 mm/h, CRP = 2+, ANA = 1/80 peripheral, RF negative, anti-dsDNA = 147 (positive > 40), anti-Sm negative, anticardiolipin IgG antibody 158 GPL (up to 12), anticardiolipin IgM antibody 5.5 MPL (up to 10), anti-beta2-glycoprotein IgG and IgM were negative and lupus anti-coagulant was 88" (18"-55"). The patient underwent Heparin and Warfarin treatment, by checking INR to be in a 2.6 to 3.5 ran-ge. Prednisolone and Hydroxychloroquine were also started.Conclusion: All patients suspected with SLE should be evaluated for antiphospholipid antibodies (APL). However, APS diagnosis requires both clinical and laboratory features.

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“…Only a few cases of ALP have been reported in the literature to date. [ 1 3 4 ] A couple of studies report that its frequency does not exceed 4% of the cohorts. [ 5 6 ] We report a case of unilateral lupus pneumonia with dense lobar consolidation of the left upper lobe.…”

mentioning

confidence: 99%

A case of large unilateral pneumonia as the presenting feature of systemic lupus erythematosus

2020

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Systemic Lupus Erythematosus Presenting as Acute Lupus Pneumonitis

Cited by 3 publications

References 5 publications

Systemic Lupus Erythematosus Presenting as Acute Lupus Pneumonitis during Pregnancy

Systemic Lupus Erythematosus Presenting as Acute Lupus Pneumonitis during Pregnancy

Secondary antiphospholipid syndrome revealed by the sudden onset of pneumonia: Case report

A case of large unilateral pneumonia as the presenting feature of systemic lupus erythematosus

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