Systemic Lupus Erythematosus Presenting with Recurrent Acute Demyelinating Polyneuropathy

Millette, Terrence J.; Subramony, S. H.; Wee, Amilia; Harisdangkul, Valee

doi:10.1159/000116042

Cited by 31 publications

(4 citation statements)

References 6 publications

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“…The disorder may be recurrent. 86 In a general overview of the problems of SLE" it was pointed out that peripheral neuropathies occur in all types of connective tissue disease and that the neuropsychiatric manifestations of SLE were most similar to those of polyarteritis nodosa (see below). According to Johnson and K i c h a r d~o n ,~~ "SLE of the nervous system is, in most cases, a vascular disease involving very small vessels."…”

Section: Other Neuropathies Associated With Abnormal Blood Rheoloqymentioning

confidence: 99%

Altered blood rheology in the pathogenesis of diabetic and other neuropathies

Simpson

1988

Muscle and Nerve

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Although a substantial literature confirms the abnormal flow properties of diabetic blood, only in a few papers has the vasculitis of diabetic neuropathy been considered to have a hemorheological cause. It is proposed that the pathogenesis of nerve lesions involves an interaction between the specialized nerve vascular system and focal ischemic lesions resulting from rheologically induced stasis. The proposition is extended into other conditions with abnormal blood rheology such as hypothyroidism, uremia, dysglobulinemia, polyarteritis nodosa, and lepromatous leprosy. It is concluded that the treatment of such polyneuropathies should include an agent which would improve the flow properties of the blood.

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Section: Other Neuropathies Associated With Abnormal Blood Rheoloqymentioning

confidence: 99%

Altered blood rheology in the pathogenesis of diabetic and other neuropathies

Simpson

1988

Muscle and Nerve

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“…Most of the SLE patients reported to date have AIDP. 3,[10][11][12] Rarely, AIDP may be the first manifestation of SLE.…”

Section: Discussionmentioning

confidence: 99%

Acute lumbosacral polyradiculoneuropathy heralding transformation to systemic lupus erythematosus in a patient with discoid lupus

Yıldız

Balaban

Şenel

et al. 2011

Lupus

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Systemic lupus erythematosus (SLE) is a multisystemic autoimmune disease with which a variety of neuropathic disorders have been associated. Among these, the acute inflammatory demyelinating polyradiculoneuropathy variant of Guillain-Barré syndrome has been well established. However, acute axonal lumbosacral polyradiculoneuropathy accompanied by albuminocytological dissociation in the cerebrospinal fluid has been extremely rarely reported in SLE. We report on a 47-year-old woman with discoid lupus presenting with acute onset of flaccid paraplegia. Extensive investigations suggested the diagnoses of axonal lumbosacral polyradiculoneuropathy and SLE. Treatment with intravenous methylprednisolone and cyclophosphamide resulted in clinical recovery. Development of immune-mediated polyneuropathy in a patient with discoid lupus should forewarn the clinician regarding transformation into the systemic form of the disease.

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“…Several authors have reported neurological manifestations similar to GBS in patients with SLE. [8][9][10][11][12][13][14] Some claimed a possible involvement of immunological abnormalities in SLE in the pathogenesis of GBS. Robson et al 14 reviewed these cases and suggested the mechanisms of GBS onset in SLE patients.…”

Section: Discussionmentioning

confidence: 99%

Guillain-Barr� syndrome accompanied by central nervous system lupus in a patient with juvenile rheumatoid arthritis

Nakajima

Higami

Yamanaka

et al. 2001

Modern Rheumatology

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We describe a 17-year-old female with juvenile rheumatoid arthritis accompanied by Guillain-Barré syndrome (GBS) during the course of central nervous system (CNS) lupus. She initially developed CNS lupus, including headache and convulsion. A high-signal area in a magnetic resonance scan of her brain with T2-weighted images was noted, and her cerebrospinal fluid exhibited increased levels of IgG and interleukin-6. Eighteen days after the onset of CNS lupus, polyneuropathy in the lower extremities developed, and a diagnosis of GBS was made. No obvious preceding infections in the upper respiratory or gastrointestinal systems were noted before the onset of GBS, indicating that GBS might be part of the symptoms of CNS lupus.

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Systemic Lupus Erythematosus Presenting with Recurrent Acute Demyelinating Polyneuropathy

Cited by 31 publications

References 6 publications

Altered blood rheology in the pathogenesis of diabetic and other neuropathies

Altered blood rheology in the pathogenesis of diabetic and other neuropathies

Acute lumbosacral polyradiculoneuropathy heralding transformation to systemic lupus erythematosus in a patient with discoid lupus

Guillain-Barr� syndrome accompanied by central nervous system lupus in a patient with juvenile rheumatoid arthritis

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