Systemic Lupus Erythematosus With Pemphigus Vulgaris

Fong, P. H.

doi:10.1001/archderm.1985.01660010030014

Cited by 25 publications

(7 citation statements)

References 5 publications

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“…MMP has been reported in patients with systemic lupus erythematosus (SLE) and rheumatoid arthritis (25)(26)(27)(28)(29)(30). PV has also been reported in patients with SLE, Sjogren's syndrome, multiple sclerosis, myasthenia gravis, systemic sclerosis, and polymyositis (31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41).…”

mentioning

confidence: 99%

RETRACTED: Simultaneous Presence of Mucous Membrane Pemphigoid and Pemphigus Vulgaris: Molecular Characterization of Both Autoantibodies

Sami

Bhol

Beutner³

et al. 2001

Clinical Immunology

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confidence: 99%

RETRACTED: Simultaneous Presence of Mucous Membrane Pemphigoid and Pemphigus Vulgaris: Molecular Characterization of Both Autoantibodies

Sami

Bhol

Beutner³

et al. 2001

Clinical Immunology

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“…MMP has been reported in patients with SLE, connective tissue disease (CTD) and RA [90–95]. Also, PV has been reported with SLE, CTD, MS, MG, alopecia universalis, insulin‐dependent diabetes mellitus, autoimmune thyroid disease, Sjögren's syndrome and systemic sclerosis [96–113].…”

Section: Discussionmentioning

confidence: 99%

Relationship between target antigens and major histocompatibility complex (MHC) class II genes in producing two pathogenic antibodies simultaneously

Zakka

Keskin

Reche

et al. 2010

Clinical and Experimental Immunology

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SummaryIn this report, we present 15 patients with histological and immunopathologically proven pemphigus vulgaris (PV). After a mean of 80 months since the onset of disease, when evaluated serologically, they had antibodies typical of PV and pemphigoid (Pg). Similarly, 18 patients with bullous pemphigoid (BP) and mucous membrane pemphigoid (MMP) were diagnosed on the basis of histology and immunopathology. After a mean of 60 months since the onset of disease, when their sera were evaluated they were found to have Pg and PV autoantibodies. In both groups of patients the diseases were characterized by a chronic course, which included several relapses and recurrences and were non-responsive to conventional therapy. The major histocompatibility complex class II (MHC II) genes were studied in both groups of patients and phenotypes associated typically with them were observed. Hence, in 33 patients, two different pathogenic autoantibodies were detected simultaneously. The authors provide a computer model to show that each MHC II gene has relevant epitopes that recognize the antigens associated with both diseases. Using the databases in these computer models, the authors present the hypothesis that these two autoantibodies are produced simultaneously due to the phenomena of epitope spreading.

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“…Severe PV was present in 5 of the 7 patients previously reported with a dual diagnosis of PV and SLE. 9,[11][12][13][14] The CTD involvement in these patients was limited in its extent and severity compared with overall populations of patients with SLE and MCTD. These patients did not have life-threatening systemic involvement, but rather tended toward a relatively mild MCTD profile with predominant antiribonucleoprotein antibodies, Raynaud's phenomenon, and swollen hands (Table II).…”

Section: Discussionmentioning

confidence: 99%

“…Systemic involvement such as pulmonary hypertension or renal involvement may develop over time. 6,7 Seven previous reports exist of a definitive dual diagnosis of SLE and PV, [8][9][10][11][12][13][14] but none of PV and MCTD. These reports lack detailed information on responses to treatment, relationship between the two diseases, and long-term follow-up.…”

mentioning

confidence: 99%