Systemic oxidative profile after tumor removal and the tumor microenvironment in melanoma patients

Bernardes, Sara Santos; Souza-Neto, Fernando P.; Ramalho, Leandra Náira Zambelli; Derossi, Daniela Rudgeri; Guarnier, Flávia Alessandra; Silva, Cassio Fernando Nunes da; Melo, Gabriella Pascoal; Simão, A. N. C.; Cecchini, Rúbens; Cecchini, Alessandra Lourenço

doi:10.1016/j.canlet.2015.03.007

Cited by 27 publications

(29 citation statements)

References 46 publications

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“…Melanomas of early stages are often removed by surgical procedures. It was evident that even after tumor removal, the MDA levels remained higher in patients who had thick tumors (Breslow thickness ≥2 mm) than the healthy controls or patients who had thin tumors (Bernardes et al, 2015). Specifically, 6 months to 5 years after surgical removal of tumors, with no sign of recurrence, patients who initially carried thick tumors showed significant higher MDA levels and higher inflammation biomarker C-reactive protein.…”

Section: Evidence Of Oxidative Stress In Melanoma Tumors and Patientsmentioning

confidence: 96%

Oxidative stress and antioxidants in the pathophysiology of malignant melanoma

Obrador

Liu‐Smith

Dellinger

et al. 2018

Biological Chemistry

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Section: Evidence Of Oxidative Stress In Melanoma Tumors and Patientsmentioning

confidence: 96%

Oxidative stress and antioxidants in the pathophysiology of malignant melanoma

Obrador

Liu‐Smith

Dellinger

et al. 2018

Biological Chemistry

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“…AuNPs have been used in this field, making it possible to destroy tumor cells noninvasively by RFA. [12][13][14] The optical properties of nanoshells can be utilized in tumorablation techniques with NIR light or RFA. Laroui et al developed nanoshells coated with gold, absorbing specific wavelengths of light.…”

Section: Gold Nmsmentioning

confidence: 99%

“…2 Many methods have been developed for tumor therapy, such as immunotherapy, 3,4 gene therapy, 5,6 and radiofrequency ablation (RFA). [7][8][9] Nevertheless, traditional radiotherapy, 10,11 surgery, [12][13][14] and especially chemotherapy 15,16 are still the major strategies utilized in clinical tumor treatments. However, chemotherapy has a number of problems, including nonspecific distribution of the drug and the lack of tumor-specific treatments.…”

Section: Introductionmentioning

confidence: 99%

Current applications and future prospects of nanomaterials in tumor therapy

Huang

Fan

Dong

et al. 2017

IJN

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Tumors are one of the most serious human diseases and cause numerous global deaths per year. In spite of many strategies applied in tumor therapy, such as radiation therapy, chemotherapy, surgery, and a combination of these treatments, tumors are still the foremost killer worldwide among human diseases, due to their specific limitations, such as multidrug resistance and side effects. Therefore, it is urgent and necessary to develop new strategies for tumor therapy. Recently, the fast development of nanoscience has paved the way for designing new strategies to treat tumors. Nanomaterials have shown great potential in tumor therapy, due to their unique properties, including passive targeting, hyperthermia effects, and tumor-specific inhibition. This review summarizes the recent progress using the innate antitumor properties of metallic and nonmetallic nanomaterials to treat tumors, and related challenges and prospects are discussed.

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“…It is well documented that cancer cells exhibit higher levels of oxidative stress than normal cells; therefore, an antioxidant system is expected to circumvent the growth of tumor cells …”

Section: Introductionmentioning

confidence: 99%

“…25,26 It is well documented that cancer cells exhibit higher levels of oxidative stress than normal cells; therefore, an antioxidant system is expected to circumvent the growth of tumor cells. [27][28][29][30][31] . Raffoul et al have recently shown that isoflavones such as genistein, daidzein, and glycitein exhibit anticancer properties, partially due to their antioxidant activities, as well as radio-sensitizers, which lead to the success of radiation-mediated suppression of the growth and metastatic potential of prostate cancer.…”

Section: Introductionmentioning

confidence: 99%

Multifunctional antioxidant nanoliposome‐mediated delivery of PTEN plasmids restore the expression of tumor suppressor protein and induce apoptosis in prostate cancer cells

Singh

Asal

Bhagat

2018

J Biomedical Materials Res

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Prostate cancer is the second leading cause of cancer death in men and about one in nine will be diagnosed in his lifetime. Loss of PTEN has been considered as one of the major factors leading to the origin of prostate cancer through modulating PI3K/AKT signaling pathways. In this study, we have prepared a multifunctional antioxidant nanoliposome containing PTEN plasmid and cerium oxide nanoparticles (CeNPs). The efficient delivery of PTEN plasmid to human prostate cancer cells (PC-3) leads to restoration of the expression of lost PTEN protein in the cell cytoplasm. The delivered superoxide dismutase (SOD)-mimetic CeNPs were also found to decrease the cytoplasmic free radical levels in prostate cancer cells. The above two activities induced DNA fragmentation and micronucleus formation in prostate cancer cells. Furthermore, it was also found that these multifunctional antioxidant nanoliposomes inhibit the PI3K/AKT signaling pathway to negatively regulate the cell viability of prostate cancer cells. The mRNA expression pattern of other relevant proteins predominantly involved in cancer cell proliferation and apoptosis suggested that the high PTEN expression could control the synthesis of oncogenic proteins. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 3152-3164, 2018.

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Systemic oxidative profile after tumor removal and the tumor microenvironment in melanoma patients

Cited by 27 publications

References 46 publications

Oxidative stress and antioxidants in the pathophysiology of malignant melanoma

Oxidative stress and antioxidants in the pathophysiology of malignant melanoma

Current applications and future prospects of nanomaterials in tumor therapy

Multifunctional antioxidant nanoliposome‐mediated delivery of PTEN plasmids restore the expression of tumor suppressor protein and induce apoptosis in prostate cancer cells

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