Systemic Oxidative Stress and Endothelial Dysfunction is Associated With an Attenuated Acute Vascular Response to Inhaled Prostanoid in Pulmonary Artery Hypertension Patients

Gabrielli, Luigi; Castro, Pablo; Godoy, Iván; Mellado, Rosemarie; Bourge, Robert C.; Alcaíno, Hernán; Chiong, Mario; Greig, Douglas; Verdejo, Hugo; Navarro, Mario; López, R.A. Medina; Toro, Barbra; Quiroga, Clara; Díaz‐Araya, Guillermo; Lavandero, Sergio; Garcı́a, Lorena

doi:10.1016/j.cardfail.2011.08.008

Cited by 33 publications

(26 citation statements)

References 23 publications

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“…10 One study has linked increased plasma levels of inflammatory cytokines to the severity of disease, and the authors of one believe that they are predictive of response to optional therapies. 9 Some studies show that patients with PAH who also have chronic obstructive pulmonary disease (COPD) and increased expression of cytokines demonstrated increased levels of vasoactive mediators, such as endothelin-1 (ET-1).…”

Section: -15mentioning

confidence: 99%

Oxidative‐Stress Biomarkers in Patients with Pulmonary Hypertension

et al. 2013

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This controlled, prospective, nonrandomized clinical investigation has as its chief strength the fact that it was done in humans with active disease and apparently on fairly modest therapeutic regimens. The aim was to present the results of oxidative-stress biomarkers in humans suffering from pulmonary artery hypertension (PAH). Inflammation and oxidative stress are essential in PAH with increased lipid peroxidation and reduced antioxidant defenses. Twenty-four adult patients of both sexes, with a mean age of 21 years, were subdivided into 2 groups: a control group of 12 healthy, nonsmoking volunteers and a PAH group (PAHG) of 12 volunteers with PAH receiving outpatient treatment. Oxidative stress was evaluated by plasma activity of reduced glutathione (GSH); lipid peroxidation was expressed by malondialdehyde (MDA) and lipid hydroperoxide (ferrous oxidation of xylenol orange [FOX] assay); vitamin E was measured by high-performance liquid chromatography and tumor necrosis factor-α (TNF-α) by enzymelinked immunosorbent assay. Statistical analyses showed significant differences for (1) the TNF-α measure, with highest values in PAHG patients; (2) the plasma GSH, with lowest values in PAHG patients; (3) vitamin E, with the lowest concentrations in PAHG patients; (4) MDA measure, with highest values in PAHG patients; and (5) the lipid hydroperoxide FOX measure, with highest values in PAHG patients. In conclusion, inflammation and oxidative stress are present in patients with PAH, as confirmed by increased lipid peroxidation, reduced GSH, and low concentrations of vitamin E.

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Section: -15mentioning

confidence: 99%

Oxidative‐Stress Biomarkers in Patients with Pulmonary Hypertension

et al. 2013

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“…Second, the systemic vascular endothelial layer is exposed to altered hemodynamic forces in the setting of increased stiffness, leading to endothelial dysfunction and release of a cascade of inflammatory markers 7, 8, 9. Third, systemic vascular function could serve as an indicator of pulmonary vascular health 10, 11, 12, 13…”

Section: Introductionmentioning

confidence: 99%

Association of Systemic Arterial Properties With Right Ventricular Morphology: The Multi‐Ethnic Study of Atherosclerosis (MESA)‐Right Ventricle Study

Al‐Naamani

Chirinos

Zamani

et al. 2016

JAHA

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BackgroundSystemic arterial stiffness is recognized as a major contributor to development of left ventricular dysfunction and failure; however, the relationship of systemic arterial properties and the right ventricle (RV) is unknown.Methods and ResultsThe associations between systemic arterial measures (total arterial compliance [TAC], systemic vascular resistance [SVR], and aortic augmentation index [AI]) and RV morphology (mass, end‐systolic [RVESV] and end‐diastolic volume [RVEDV], and ejection fraction [RVEF]) were examined using data from the Multi‐Ethnic Study of Atherosclerosis. All analyses were adjusted for anthropometric, demographic, and clinical variables and the corresponding left ventricular parameter. A total of 3842 subjects without clinical cardiovascular disease were included with a mean age of 61 years, 48% male, 39% non‐Hispanic white, 25% Chinese‐American, 23% Hispanic, and 13% black. RV measures were within normal range for age and sex. A 1‐mL/mm Hg decrease in TAC was associated with 3.9‐mL smaller RVESV, 7.6‐mL smaller RVEDV, and 2.4‐g lower RV mass. A 5‐Wood‐unit increase in SVR was associated with 0.6‐mL decrease in RVESV, 1.7‐mL decrease in RVEDV, and 0.4‐g decrease in RV mass. A 1% increase in AI was associated with 0.2‐mL decrease in RVEDV. We found significant effect modification by age, sex, and race for some of these relationships, with males, whites, and younger individuals having greater decreases in RV volumes and mass.ConclusionsMarkers of increased systemic arterial load were associated with smaller RV volumes and lower RV mass in a population of adults without clinical cardiovascular disease.

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“…The antioxidant enzymes SOD, GPx, and CAT are regarded as the first line of defense against the ROS generated during oxidative stress (Gabrielli et al 2011 Fig. 2 Oxidative stress parameters.…”

Section: Discussionmentioning

confidence: 99%

Postprandial oxidative stress is modulated by dietary fat in adipose tissue from elderly people

Meza-Miranda

Camargo

Rangel‐Zúñiga

et al. 2013

AGE

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We have investigated whether dietary fat modifies the postprandial oxidative stress in adipose tissue of elderly people. Twenty participants received three diets for 4 weeks each: SFA-rich diet, Mediterranean (Med) diet enriched in MUFA with virgin olive oil, and a low-fat, high-carbohydrate diet enriched in n-3 PUFA (α-linolenic acid from plant origin) (CHO-PUFA diet). After 12 h of fasting, volunteers received a breakfast reflecting the fatty acid composition of the diet ingested in the preceding dietary period. Med diet induced higher postprandial SOD2 and TrxR mRNA levels, and CHO-PUFA diet induced higher GPx1 and TrxR mRNA levels compared with SFA-rich diet. Med and CHO-PUFA breakfasts induced a postprandial increase in plasma reduced glutathione (GSH), and a greater postprandial GSH/oxidized glutathione ratio compared to the SFArich diet. Our study suggests that the consumption of Med and CHO-PUFA diets may reduce postprandial oxidative stress compared to an SFA-rich diet, which may be due to higher antioxidant enzymes gene expression in adipose tissue.

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Systemic Oxidative Stress and Endothelial Dysfunction is Associated With an Attenuated Acute Vascular Response to Inhaled Prostanoid in Pulmonary Artery Hypertension Patients

Cited by 33 publications

References 23 publications

Oxidative‐Stress Biomarkers in Patients with Pulmonary Hypertension

Oxidative‐Stress Biomarkers in Patients with Pulmonary Hypertension

Association of Systemic Arterial Properties With Right Ventricular Morphology: The Multi‐Ethnic Study of Atherosclerosis (MESA)‐Right Ventricle Study

Postprandial oxidative stress is modulated by dietary fat in adipose tissue from elderly people

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