Systemic prognostic score and nomogram based on inflammatory, nutritional and tumor markers predict cancer-specific survival in stage II–III gastric cancer patients with adjuvant chemotherapy

Liu, Xuechao; Wu, Zhiming; Lin, Enzi; Li, Wei; Chen, Yingbo; Sun, Xiaowei; Zhou, Zhiwei

doi:10.1016/j.clnu.2018.07.015

Cited by 53 publications

(60 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Cancer-related inflammation and malnutrition negatively affect cancer outcome. Liu et al reported that inflammatory and nutritional markers were independent predictive indexes for the survival of gastric cancer patients (14). Combined indexes of inflammation and nutrition, such as PNI (18,32), SIS (22,33), and AGR (16,34) have been proved to be related to survival in cancers.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Prognostic Value of Clinical Biochemistry-Based Indexes in Nasopharyngeal Carcinoma

et al. 2020

View full text Add to dashboard Cite

Inflammation and nutritional status have significant effects on the prognosis of cancer patients. This study investigated the predictive value of clinical biochemistry-based indexes in nasopharyngeal carcinoma (NPC). This retrospective study included 559 NPC patients and 500 patients with chronic rhinitis. Continuous variables were measured by t-test. The area under curves (AUC) was used to determine the diagnostic and prognostic value for NPC. Kaplan-Meier methods and the log-rank test were used to analyze overall survival (OS) and disease-free survival (DFS) of the patients. Cox and logistic regression analysis were used to analyze the independent prognostic risk factors for survival and influencing factors of side effects after treatment, respectively. The study results revealed that most indexes of NPC and rhinitis were significantly different between the two groups. In the survival analysis, the systemic inflammation score (SIS), prognostic nutritional index (PNI), albumin/globulin ratio (AGR), albumin (ALB), urea nitrogen (BUN) and creatinine (CREA) had significant influence on the OS and DFS. AGR was the optimal prognostic indicator for NPC. Among these indexes, SIS, AGR, BUN and CERA were independent prognostic factors of OS, AGR and PNI were independent prognostic factors of DFS. Most indexes were risk factors of side effects occurred in radiotherapy. In conclusion, the clinical biochemistry-based indexes, are reliable and of low-cost, therefore, they can be used in predicting diagnosis, prognosis and treatment plans of NPC.

show abstract

Section: Discussionmentioning

confidence: 99%

“…The nutrition has a profound influence on leukocytes and proinflammatory carcinogenic action of the anticancer immune response (13). The nutritional status is closely related to the prognosis of cancer patients and the global incidence of cancer-associated malnutrition ranges from 30 to 85% (14).…”

Section: Introductionmentioning

confidence: 99%

Prognostic Value of Clinical Biochemistry-Based Indexes in Nasopharyngeal Carcinoma

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Unfortunately, GC is difficult to diagnose at an early stage. Therefore, people are very interested in finding prognostic markers for these potentially curable patients [9][10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Identification of novel biomarkers, MUC5AC, MUC1, KRT7, GAPDH, CD44 for gastric cancer

Yang¹

2020

Med Oncol

View full text Add to dashboard Cite

Gastric cancer (GC) is one of the most common malignant tumors in the world, and it is also the third largest cause of cancerrelated death in the world. As far as we know, no biomarker has been widely accepted for early diagnosis and prognosis prediction of gastric cancer. The purpose of this study is to find potential biomarkers to predict the prognosis of GC. The gene expression profiles of GSE2685 were downloaded from GEO database. Morpheus was used to calculate the differentially expressed genes (DEGs) between primary advanced gastric cancer tissues and noncancerous gastric tissues. The gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes pathway (KEGG) enrichment analyses were performed, and protein-protein interaction (PPI) network of DEGs was constructed. Kaplan-Meier Plotter was used to determine the overall survival (OS) outcomes of UC5AC, MUC1, KRT7, GAPDH, CD44, and GEPIA was used to determine the Pearson correlation analysis. In total, 710 DEGs were identified in GC, including 396 upregulated genes and 314 downregulated genes. GO enrichment revealed that they were mainly enriched in binding, catalytic activity, cellular process and cell. KEGG pathway revealed that they were mainly enriched in metabolic pathways, pathways in cancer and PI3K-Akt signaling pathway. MUC5AC, MUC1, KRT7, GAPDH, CD44 were identified from the PPI network. MUC5AC, MUC1, KRT7, GAPDH, CD44 were demonstrated to have prognostic value for patients with GC. MUC5AC, MUC1 exhibited low expression levels in GC tissues, KRT7, GAPDH, CD44 presented high expression levels in GC tissues. In particular, KRT7 is hardly expressed in normal gastric tissues. MUC5AC and MUC1 were negatively correlated with GAPDH, CD44, respectively; and GAPDH was positively correlated with CD44 and KRT7, respectively. Moreover. MUC5AC, MUC1, KRT7, GAPDH, and CD44 are not only related to GC but also to apoptosis pathway. Results from the present study suggested that MUC5AC, MUC1, KRT7, GAPDH, CD44 may represent novel prognostic biomarkers for GC.

show abstract

“…The independent risk factors for poor GC prognosis include NLR, PLR, brinogen, PNI, GPS, CRP/Alb, among others. Also, some studies have combined these systemic in ammatory markers with or without TNM stage to provide new prognostic tools [21][22][23]. However, most of these studies were retrospective, and reported inconsistent results, particularly on the signi cance of each in ammatory index and the threshold value.…”

Section: Discussionmentioning

confidence: 99%

Clinical significance of peripheral blood-derived inflammation markers in advanced gastric cancer after radical resection

Chen

Zheng

et al. 2020

Preprint

View full text Add to dashboard Cite

Background and objective: The prognostic significance of peripheral blood-derived inflammation markers in patients with gastric cancer (GC) has not been elucidated. This study aimed to investigate the relationship between systemic inflammatory markers and GC prognosis. Methods:A prospective observational cohort study involving 598 patients was conducted to analyze the prognosis of GC based on systemic inflammatory markers. The following peripheral blood-derived inflammation markers were evaluated: the neutrophil-lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR), systemic immune-inflammation index (SII), C-reactive protein/albumin (CRP/Alb) ratio, Glasgow Prognostic Score (GPS), modified Glasgow Prognostic Score (mGPS), prognostic nutrition index (PNI), and prognostic index (PI). The receiver operating characteristics (ROC) curve and the Youden index were used to determine the optimal cutoff values. Univariate and multivariate analysis of prognostic factors was conducted accordingly. Results:The optimal cutoff values of the PNI, fibrinogen, NLR, PLR, SII, and CRP/Alb were 49.5, 397ng/dl, 2.5, 154, 556, and 0.05, respectively. Multivariate analysis showed that age, PLR, TNM stage, and chemotherapy were the independent prognostic factors for advanced gastric cancer (AGC).Adjuvant chemotherapy improved the long-term prognosis of patients with PLR ≥154, but chemotherapy had no significant effect on the survival of patients with PLR <154. Conclusions:Our findings show that higher PLR (≥154) is an independent risk factor for poor prognosis in GC patients. Besides, PLR can predict adjuvant chemotherapy (oxaliplatin/5-fluorouracil combination) response in patients with GC after surgery.

show abstract

Systemic prognostic score and nomogram based on inflammatory, nutritional and tumor markers predict cancer-specific survival in stage II–III gastric cancer patients with adjuvant chemotherapy

Cited by 53 publications

References 34 publications

Prognostic Value of Clinical Biochemistry-Based Indexes in Nasopharyngeal Carcinoma

Prognostic Value of Clinical Biochemistry-Based Indexes in Nasopharyngeal Carcinoma

Identification of novel biomarkers, MUC5AC, MUC1, KRT7, GAPDH, CD44 for gastric cancer

Clinical significance of peripheral blood-derived inflammation markers in advanced gastric cancer after radical resection

Contact Info

Product

Resources

About