Systemic Rasamsonia piperina infection in a German shepherd cross dog

Lodzinska, Joanna; Cazzini, Paola; Taylor, Claire S.; Harris, Jenifer; Kilpatrick, Scott; Liuti, Tiziana; Paterson, Gavin K.

doi:10.1099/jmmcr.0.005125

Cited by 6 publications

(7 citation statements)

References 22 publications

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“…In veterinary patients, there are few case reports describing uncommon fungal proliferation such as Oxyporus corticola or Rasamsonia piperina causing osteomyelitis, or Blastomyces and Talaromyces georgiensis causing arthritis. 5,[12][13][14] To the author's knowledge, this is the first report of Trichophyton's osteoarticular infection in a dog.…”

Section: Discussionmentioning

confidence: 99%

Osteoarticular Infection of the Shoulder Joint Due to Trichophyton Spp. in a Dog

Feline¹,

Cabassu²

2021

VCOT Open

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A 10-year-old Labrador Retriever was referred for persistent lameness due to chronic right shoulder pain, unresponsive to various pain management therapies. Radiographs indicated signs of severe degenerative changes in the joint. Synovial fluid analysis was not diagnostic. Septic arthritis was suspected based on computed tomography and clinical signs. Arthroscopy allowed joint exploration, tissue biopsies, and copious joint lavage. Trichophyton spp. proliferation was identified on antimicrobial culture and histological analysis on samples obtained during arthroscopy. Oral griseofulvin therapy was initiated. Two months later, the referring veterinarian decided to interrupt the treatment after a negative synovial culture despite persistent lameness. Euthanasia was elected upon after pain also appeared on the tarsus; a post-mortem exam was not authorized by the owner. The origin of the infection remains unclear as this patient had no skin lesions and its immunological status was unknown. However, dermatophytosis has been reported in healthy dogs without skin lesions. To the author's knowledge, this is the first report of an osteoarticular infection with a dermatophyte in a dog.

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Section: Discussionmentioning

confidence: 99%

Osteoarticular Infection of the Shoulder Joint Due to Trichophyton Spp. in a Dog

Feline¹,

Cabassu²

2021

VCOT Open

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“…Disseminated mycoses, including by Rasamsonia , generally occur in immunocompromised humans and animals, [ 6 , 7 ]. German shepherd dogs (GSD), especially females, are overrepresented for disseminated mycoses [ 8 ], which may be due to an inherited abnormality in IgA and/or mucosal immunity dysfunction [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

“…German shepherd dogs (GSD), especially females, are overrepresented for disseminated mycoses [ 8 ], which may be due to an inherited abnormality in IgA and/or mucosal immunity dysfunction [ 9 ]. However, not all dogs with disseminated mycoses have low serum IgA, so the underlying mechanism of infection appears to be more complex [ 7 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

“…Systemic mycosis due to R. argillacea complex causing has been reported in 11 cases in dogs seven of which were in GSDs in the UK and USA [ 7 , [11] , [12] , [13] ]. Affected animals had clinical signs in various body systems including nervous, respiratory, cardiovascular, musculoskeletal, gastrointestinal, lymphatic, and urinary systems.…”

Section: Introductionmentioning

confidence: 99%

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Disseminated Rasamsonia argillacea complex infection presenting as intraventricular brain hemorrhage in a German shepherd dog in Australia

Skinner,

Allavena,

Hoffmann

et al. 2024

Medical Mycology Case Reports

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“…Rasamsonia spp. have been described as pathogens of dogs in 4 case reports 7,11‐13 . Three of the 4 dogs were German Shepherd dogs evaluated for multisystemic clinical signs and were euthanized because of progressive disease and declining quality of life.…”

Section: Introductionmentioning

confidence: 99%

Disseminated Rasamsonia argillacea species complex infections in 8 dogs

Dear

Reagan

Hulsebosch

et al. 2021

Veterinary Internal Medicne

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Background Clinical features, treatment, and outcome of opportunistic infections with Rasamsonia spp., a nonpigmented filamentous mold, are not well documented in dogs. Objectives Describe clinical, radiographic, pathologic features, and outcome of dogs with disseminated Rasamsonia species complex infections. Animals Eight client‐owned dogs. Methods Retrospective case series. Medical records were reviewed to describe signalment, history, clinicopathologic and imaging findings, microbiologic and immunologic results, cyto‐ and histopathologic diagnoses, treatment, and outcome. Results Presenting complaints were nonspecific with anorexia (n = 5) and back pain (n = 4) most common. Five dogs were German Shepherd dogs. Six dogs had multifocal discospondylitis and 2 had pleural effusion. Six dogs had Rasamsonia piperina and 2 had Rasamsonia argillacea infections with isolates identified using DNA sequencing. Rasamsonia spp. were isolated by urine culture in 5 of 7 dogs. Five of 6 dogs had positive serum Aspergillus galactomannan antigen enzyme immunoassay (EIA) results. Median survival time was 82 days, and 317 days for dogs that survived to discharge. Four died during initial hospitalization (median survival, 6 days). All isolates had low minimum effective concentrations (MECs) to echinocandins with variable minimum inhibitory concentrations (MICs) for azole antifungal drugs. Conclusions and Clinical Importance Rasamsonia spp. infections in dogs are associated with multisystemic disease involving the vertebral column, central nervous system, kidneys, spleen, lymph nodes, lungs, and heart. The infection shares clinical features with other systemic mold infections and can be misidentified when using phenotypical microbiologic methods. Molecular techniques are required to identify the organism and guide appropriate antifungal treatment.

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Systemic Rasamsonia piperina infection in a German shepherd cross dog

Cited by 6 publications

References 22 publications

Osteoarticular Infection of the Shoulder Joint Due to Trichophyton Spp. in a Dog

Osteoarticular Infection of the Shoulder Joint Due to Trichophyton Spp. in a Dog

Disseminated Rasamsonia argillacea complex infection presenting as intraventricular brain hemorrhage in a German shepherd dog in Australia

Disseminated Rasamsonia argillacea species complex infections in 8 dogs

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