Systemic Revealing Pharmacological Signalling Pathway Networks in the Hippocampus of Ischaemia-Reperfusion Mice Treated with Baicalin

Li, Haixia; Zhang, Yingying; Yu, Yanan; Li, Bing; Chen, Yin-ying; Wu, Hongli; Wang, Jingtao; Li, Jun; Xiong, Xingjiang; He, Qiongyong; Tian, Jinzhou; Wang, Zhong; Wang, Jie

doi:10.1155/2013/630723

Cited by 11 publications

(5 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Baicalin activation of the cyclinD-SMAD3-TGF beta network pathway may improve wound healing after cerebral ischemia. In general, this study showed that the clinical effectiveness of baicalin was based on the complementary effects of multiple pathways and networks [ 107 ].…”

Section: Pharmacological Signaling Pathway Network Analysismentioning

confidence: 99%

The Effects of Baicalin and Baicalein on Cerebral Ischemia: A Review

2017

View full text Add to dashboard Cite

Ischemic stroke, producing a high mortality and morbidity rate, is a common clinical disease. Enhancing the prevention and control of ischemic stroke is particularly important. Baicalin and its aglycon baicalein are flavonoids extracted from Scutellaria baicalensis, an important traditional Chinese herb. In recent years, a growing body of evidences has shown that baicalin and baicalein could be effective in the treatment of cerebral ischemia. Pharmacokinetic studies have shown that baicalin could penetrate the blood-brain barrier and distribute in cerebral nuclei. Through a variety of in vitro and in vivo models of ischemic neuronal injury, numerous studies have demonstrated that baicalin and baicalein have salutary effect for neuroprotection. Especially, the studies on the pharmacological mechanism showed that baicalin and baicalein have several pharmacological activities, which include antioxidant, anti-apoptotic, anti-inflammatory and anti-excitotoxicity effects, protection of the mitochondria, promoting neuronal protective factors expression and adult neurogenesis effects and many more. This review focuses on the neuroprotective effects of baicalin and baicalein in ischemia or stroke-induced neuronal cell death. We aimed at collecting all important information regarding the neuroprotective effect and its pharmacological mechanism of baicalin and baicalein in various in vivo and in vitro experimental models of ischemic neuronal injury.

show abstract

Section: Pharmacological Signaling Pathway Network Analysismentioning

confidence: 99%

The Effects of Baicalin and Baicalein on Cerebral Ischemia: A Review

2017

View full text Add to dashboard Cite

show abstract

“…At 24 h after the experimental interventions, the rats were deeply anesthetized, sacrificed by an overdose of anesthesia and quickly treated with a cardiac perfusion of 4% paraformaldehyde. The hippocampi from 3 rats per group were extracted and cut into 12-µm coronal sections with a cryostat (CM 3000; Leica, Manheim, Germany) then placed on glass slides and stored at -80˚C (21,22).…”

Section: Chemicalsmentioning

confidence: 99%

Resveratrol relieves ischemia‑induced oxidative stress in the hippocampus by activating SIRT1

Zhang

Zhao

et al. 2015

Exp Ther Med

View full text Add to dashboard Cite

Abstract. Resveratrol, a naturally occurring phytoalexin, acts as an activator of sirtuin 1 (SIRT1) and has been shown to have a neuroprotective role in various models. Healthy adult male Sprague-Dawley rats were subjected to cerebral ischemia in order to study the protective effect of resveratrol on the brain following ischemia, and to investigate the effects of SIRT1 activation on the hippocampus. Untreated and resveratrol-treated rats were anesthetized prior to undergoing surgery to induce middle cerebral artery occlusion followed by reperfusion. SIRT1 expression was evaluated by immunohistochemistry, western blotting and reverse transcription-quantitative polymerase chain reaction, and SIRT1 activity was also evaluated. In addition, terminal deoxynucleotidyl transferase dUTP nick end-labeling (TUNEL) and Nissl staining assays were conducted and the levels of reactive oxygen species were determined. It was observed that resveratrol significantly decreased the number of TUNEL-positive cells and increased the expression of SIRT1 mRNA in a dose-dependent manner.This was accompanied by increases in SIRT1 protein expression levels and SIRT1 activity. The results demonstrate the neuroprotective and antioxidant effects of resveratrol against ischemia-induced apoptosis in the rat hippocampus.

show abstract

“…The neurons were protected from an excitotoxic injury by inhibiting CaMKII. (Li et al, 2013) aimed to explore any potential correlation between the neuroprotective effects of baicalin on the ischemic area and CaMKII. The protein expression of CaMKII and p-CaMKII was evaluated in gerbils belonging to various treatment groups.…”

Section: Suppressing Ca 2+ Overloadingmentioning

confidence: 99%

Novel insight into the therapeutical potential of flavonoids from traditional Chinese medicine against cerebral ischemia/reperfusion injury

Zhou,

Sun,

Zhang

et al. 2024

Front. Pharmacol.

View full text Add to dashboard Cite

Cerebral ischemia/reperfusion injury (CIRI) is a major contributor to poor prognosis of ischemic stroke. Flavonoids are a broad family of plant polyphenols which are abundant in traditional Chinese medicine (TCM) and have beneficial effects on several diseases including ischemic stroke. Accumulating studies have indicated that flavonoids derived from herbal TCM are effective in alleviating CIRI after ischemic stroke in vitro or in vivo, and exhibit favourable therapeutical potential. Herein, we systematically review the classification, metabolic absorption, neuroprotective efficacy, and mechanisms of TCM flavonoids against CIRI. The literature suggest that flavonoids exert potential medicinal functions including suppressing excitotoxicity, Ca2+ overloading, oxidative stress, inflammation, thrombin’s cellular toxicity, different types of programmed cell deaths, and protecting the blood-brain barrier, as well as promoting neurogenesis in the recovery stage following ischemic stroke. Furthermore, we identified certain matters that should be taken into account in future research, as well as proposed difficulties and opportunities in transforming TCM-derived flavonoids into medications or functional foods for the treatment or prevention of CIRI. Overall, in this review we aim to provide novel ideas for the identification of new prospective medication candidates for the therapeutic strategy against ischemic stroke.

show abstract

Systemic Revealing Pharmacological Signalling Pathway Networks in the Hippocampus of Ischaemia-Reperfusion Mice Treated with Baicalin

Cited by 11 publications

References 35 publications

The Effects of Baicalin and Baicalein on Cerebral Ischemia: A Review

The Effects of Baicalin and Baicalein on Cerebral Ischemia: A Review

Resveratrol relieves ischemia‑induced oxidative stress in the hippocampus by activating SIRT1

Novel insight into the therapeutical potential of flavonoids from traditional Chinese medicine against cerebral ischemia/reperfusion injury

Contact Info

Product

Resources

About