Systemic Route for Retinal Drug Delivery: Role of the Blood-Retinal Barrier

Polarized Distribution of Heme Transporters in Retinal Pigment Epithelium and Their Regulation in the Iron-Overload Disease Hemochromatosis

“…The outer blood-retinal barrier is composed of the retinal pigment epithelium (RPE), and the inner blood-retinal barrier is composed of endothelial cells of the retinal vasculature. 16,17 RPE supplies nutrients to the outer one third of the neural retina, and one of the functions of this cell layer is to transport iron from systemic blood into the neural retina. Whether this cell also transports heme from systemic blood into the neural retina is not known.…”