2019
DOI: 10.1111/apha.13401
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Systemic serotonin inhibits brown adipose tissue sympathetic nerve activity via a GABA input to the dorsomedial hypothalamus, not via 5HT1A receptor activation in raphe pallidus

Abstract: Aim Serotonin (5‐hydroxytryptamine, 5‐HT), an important neurotransmitter and hormone, modulates many physiological functions including body temperature. We investigated neural mechanisms involved in the inhibition of brown adipose tissue (BAT) sympathetic nerve activity (SNA) and BAT thermogenesis evoked by 5‐HT. Methods Electrophysiological recordings, intravenous (iv) injections and nanoinjections in the brains of anaesthetized rats. Results Cooling‐evoked increases in BAT SNA were inhibited by the intra‐ros… Show more

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Cited by 15 publications
(13 citation statements)
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References 84 publications
(180 reference statements)
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“…11 Mota et al elucidate the central mechanism through which increases in serotonin reduce body temperature by inhibiting brown adipose tissue sympathetic nerve activity, metabolism and thermogenesis. 12 Exposure to radiation conjures images of radioactive wastelands. Ultraviolet light, to humans, is the most relevant form of radiation on a daily basis, which may be both a blessing and a curse.…”
Section: Environment and Exposurementioning
confidence: 99%
See 1 more Smart Citation
“…11 Mota et al elucidate the central mechanism through which increases in serotonin reduce body temperature by inhibiting brown adipose tissue sympathetic nerve activity, metabolism and thermogenesis. 12 Exposure to radiation conjures images of radioactive wastelands. Ultraviolet light, to humans, is the most relevant form of radiation on a daily basis, which may be both a blessing and a curse.…”
Section: Environment and Exposurementioning
confidence: 99%
“…While cold exposure is studied in relation to metabolic disorders to increase energy expenditure, 9 Lomo et al recently analysed the different components of muscle activity that lead to adaptive heat generation 10 in addition to the classically described thermogenetic ‘shivering’ 11 . Mota et al elucidate the central mechanism through which increases in serotonin reduce body temperature by inhibiting brown adipose tissue sympathetic nerve activity, metabolism and thermogenesis 12 …”
mentioning
confidence: 99%
“…Consequentemente, a ativação de neurônios GABAérgicos da área pré-óptica medial e da região ventral da área pré-óptica lateral causa a inibição de neurônios simpatoexcitatórios (195).…”
Section: Serotoninaunclassified
“…Tc: temperatura corporal, Tpele: temperatura da pele. Fonte: Mota et al, 2019(195).Tabela 2 -Efeito da nanoinjeção local de WAY100635 no rRPa na ANS TAM e na termogênese pelo TAM. Pós" foram obtidos durante o período de 30 s durante o pico da resposta do fármaco até 10 min após a sua administração.…”
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