Systemic side effects of topical latanoprost

In Vivo Assessment of Aqueous Humor Dynamics Upon Chronic Ocular Hypertension and Hypotensive Drug Treatment Using Gadolinium-Enhanced MRI

“…This bypass path may lead to a relatively larger amount of pharmaceutical entering the circulatory system compared with oral administration 47 and may potentially lead to adverse side effects in the circulatory system and the CNS. 46,[48][49][50][51][52] Systemic cardiovascular effects such as hypotension and bradycardia 45,53 and CNS depression 54,55 have been reported as side effects of brimonidine topical administration especially in infants and children. Although the IOP of the treated right eye remained significantly lower than that of the left control eye, similar to observations in previous reports, 56 the underlying reasons for the drastic differences in Gd signal time courses in both eyes of the brimonidine-treated group compared to all other groups are currently unclear; nevertheless, they suggest significant systemic absorption and transfer of antiglaucoma agent to the fellow eye (the consensual ophthalmotonic reaction), 57 cardiovascular effect of brimonidine administration, and involvement of unexplored aqueous humor pathways other than suppression of inflow or facilitation of outflow 58 that may predominate in IOP alteration.…”

Severe cutaneous reaction to latanoprost eye drops

“…There have also been isolated case reports of rarer side effects, including central macular edema,[ 5 ] reactivation of herpes simplex,[ 6 ] and even chest pain. [ 4 ] However, reports of side effects involving the skin are rarer, with only one report of increased skin pigmentation following use of latanoprost. [ 7 ]…”

“…[ 3 ] There are also a number of rarer systemic side effects reported in the literature, including chest pain. [ 4 ] Here we report a rare case of a severe cutaneous reaction to latanoprost eye drops.…”

Accidental Overdose of Travoprost

“…Chest tightness with the use of ocular prostaglandins has been reported. 8 Other systemic adverse events include nasopharyngitis, upper respiratory tract infection, and headache. 6 Prostaglandins are reported to have no effect on heart rate or blood pressure.…”