2014
DOI: 10.4103/0019-5154.139874
|View full text |Cite
|
Sign up to set email alerts
|

Systemic side-effects of topical corticosteroids

Abstract: With the introduction of topical corticosteroids, a milestone has been achieved in dermatologic therapy; owing to its potent anti-inflammatory and ant proliferative effects, it became possible to treat some hitherto resistant dermatoses. But this magic drug can cause enough mischief if used inappropriately. Children are more susceptible to the systemic adverse effects because of enhanced percutaneous absorption through their tender skin. So, systemic side effects should be kept in mind while prescribing this t… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1

Citation Types

1
66
0
5

Year Published

2016
2016
2024
2024

Publication Types

Select...
6
2
1

Relationship

0
9

Authors

Journals

citations
Cited by 119 publications
(81 citation statements)
references
References 39 publications
1
66
0
5
Order By: Relevance
“…Éstos se encuentran disponibles en diferentes presentaciones, concentraciones y potencias (4) , clasificándose en grupos I al VII, según esta última característica (5-7) (tabla 1) (10) . El clobetasolpropionato es el preparado de mayor potencia asociado a efectos secundarios sistémicos, pero cualquier corticoide aplicado en cantidad, duración y extensión suficientes puede producirlos (5) .…”
Section: Discussionunclassified
“…Éstos se encuentran disponibles en diferentes presentaciones, concentraciones y potencias (4) , clasificándose en grupos I al VII, según esta última característica (5-7) (tabla 1) (10) . El clobetasolpropionato es el preparado de mayor potencia asociado a efectos secundarios sistémicos, pero cualquier corticoide aplicado en cantidad, duración y extensión suficientes puede producirlos (5) .…”
Section: Discussionunclassified
“…
systemic uptake of the drug and optionally with adrenal syndrome [5]. The symptoms of adrenal insufficiency usually begin gradually and diarrhea occur in ∼50% of cases.

Therefore, in our opinion, this interesting study needs further investigation about the real clinical relevance of probiotics supplementation in preventing gastrointestinal adverse events associated with dacomitinib.

…”
mentioning
confidence: 93%
“…systemic uptake of the drug and optionally with adrenal syndrome [5]. The symptoms of adrenal insufficiency usually begin gradually and diarrhea occur in ∼50% of cases.…”
mentioning
confidence: 99%
“…2 Other commonly available topical agents such as corticosteroids though effective are more likely to cause local or systemic side effects after long-term use. 3 These safety and efficacy concerns of the currently available topical agents have prompted research to develop an alternative skin lightening agent, with efficacy comparable to hydroquinone, but with better safety profile. Evidence shows that the active compounds isolated from plants such as arbutin, aloesin, gentisic acid, flavonoids, hesperidin, licorice, niacinamide, yeast derivatives and polyphenols are potent inhibitors of melanin formation and are not usually associated with cytotoxicity or mutagenicity of melanocytes.…”
Section: Introductionmentioning
confidence: 99%