Systemic therapies for preventing or treating aromatase inhibitor-induced musculoskeletal symptoms in early breast cancer

Roberts, Kate; Rickett, Kirsty; Chatfield, Mark D.; Woodward, Natasha

doi:10.1002/14651858.cd013167

Cited by 2 publications

(2 citation statements)

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“…It is challenging to assess the overall effectiveness of these interventions given the paucity and variable quality of data available in the literature. A recent Cochrane review on RCTs for AIA/AIMSS ( 15 ) identified 17 high-quality studies (4 prevention studies, 13 treatment studies) with over 2000 randomized patients, and the results are summarized in Table 1 . Overall, there was very low-certainty evidence for the evaluated systemic therapies for the prevention or management of AIA/AIMSS.…”

Section: Discussionmentioning

confidence: 99%

“…Therapies evaluated in this systematic review included etoricoxib ( 17 ), testosterone ( 18 , 19 ), duloxetine ( 12 ), calcitonin ( 20 ), omega-3 fatty acid supplementation ( 21 , 22 ), vitamin D3 supplementation ( 23 – 26 ), tart cherry ( 27 ), bionic tiger bone capsules ( 28 ), Yi Shen Jian Gu granules ( 29 ), emu oil ( 30 ), and Cat’s claw ( 31 ). Standardization of the measurement of outcomes in AIA/AIMSS, including patient reported outcomes (PROs), and standardization of the time points for assessment would improve research quality and reduce heterogeneity in comparing studies ( 15 ).…”

Section: Discussionmentioning

confidence: 99%

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Aromatase inhibitor-induced arthralgia ameliorated by Mediterranean diet and active lifestyle guided by continuous glucose monitoring: a case report and review of the literature

Wilson,

Grewelle,

Gupta

et al. 2024

Front. Oncol.

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Aromatase inhibitors (AIs) are a cornerstone adjuvant treatment of many hormone receptor-positive breast cancers, and nearly half of women taking aromatase inhibitors suffer from AI-induced arthralgia (AIA), also known as AI-associated musculoskeletal syndrome (AIMSS), for which there are limited evidence-based treatments. Pharmacologic management and complementary methods including supplements, exercise, physical therapy, yoga, acupuncture, and massage have all shown mixed results. Comprehensive diet and lifestyle strategies are understudied in AIA/AIMSS despite their disease-modifying effects across many chronic conditions. Here we report a case of a woman with stage 2 estrogen and progesterone receptor-positive invasive ductal carcinoma on adjuvant anastrozole whose AI-induced arthralgia was durably controlled through a Mediterranean plant-forward diet and daily physical activity guided by continuous glucose monitoring. We posit that diet and a lifestyle inclusive of daily physical activity constitute a low-cost, low-risk, and potentially high-reward strategy for controlling common AI-induced musculoskeletal symptoms and that more investigation in this arena, including well-designed randomized trials, is warranted.

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Section: Discussionmentioning

confidence: 99%