The paper considers working conditions characterized by the presence of harmful and dangerous factors of the natural and industrial environment, as well as the functional body state of builders performing various jobs. As the subject of scientific research, the levels of harmful and dangerous factors of the labor process in the warm and cold periods of the year and physiological indicators characterizing the dynamics of changes in the functional body state of builders working on open construction sites under the influence of the environment were chosen. The purpose of the research is to develop measures to create safe working conditions, as well as to improve the performance and maintain the health of builders. To achieve this goal, the following tasks were solved: the hygienic features of the working conditions of construction work were determined and the leading natural, industrial, harmful and dangerous production factors were identified; the quantitative and qualitative characteristics of harmful factors and the reasons for their formation were studied; professional characteristics of the work of builders with an assessment of the severity and intensity of the labor process were given; a set of measures aimed at optimizing working conditions and maintaining the health of builders was developed. The paper notes that the whole complex of harmful production factors affects the functional state and performance of builders of various professions.