Systolic and diastolic function in patients with systemic sclerosis

Poantă, Laura; Dadu, Razvan T.; Tiboc, Cristina; Rednic, Simona; Dumitraşcu, Dan L.

doi:10.1016/j.ejim.2008.10.011

Cited by 27 publications

(24 citation statements)

References 13 publications

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“…However, the authors estimated RV diastolic function only by pulsed Doppler imaging (IVRT and E/A ratio), which can partly explain the differences in our investigation. 20 On the other hand, they did not find the relationship between LV diastolic function and pulmonary function as our results showed. However, Vonk 4 However, authors stated that other factors, as age, gender, and arterial blood pressure, influenced LV abnormalities.…”

Section: Discussioncontrasting

confidence: 75%

“…D'Andrea et al found that Rodnan skin score and SPAP correlated with RV diastolic function, 3 and Vonk et al found a relationship between SPAP and the RV Tei index, 18 which agrees with our results. 20 The neuroendocrine characteristics of patients with SSc have been widely studied in the last few years. 19 Our investigation showed that some clinical factors (BNP level, DLCO, and PVR) and parameters of RV diastolic and global function (tricuspid E/A, E/e septal and E/e lateral ratio, and RV Tei index), regardless of age, gender, and arterial blood pressure, significantly impacted LV diastolic and global function.…”

Section: Discussionmentioning

confidence: 99%

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Which Factors Impact Myocardial Function in Systemic Sclerosis?

Ivanović

Tadić

Zlatanović³

et al. 2011

Echocardiography

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Section: Discussioncontrasting

confidence: 75%

Section: Discussionmentioning

confidence: 99%

Which Factors Impact Myocardial Function in Systemic Sclerosis?

Ivanović

Tadić

Zlatanović³

et al. 2011

Echocardiography

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“…Diastolic dysfunction is clinically important and according to recent data is a marker of increased risk of death in SSc patients [9]. There are several studies evaluating left (LV) but only a few on right ventricular (RV) diastolic function in SSc patients [10–14]. Moreover, there is limited evidence on potential progression of diastolic dysfunction during follow-up [15].…”

Section: Introductionmentioning

confidence: 99%

Heart diastolic dysfunction in patients with systemic sclerosis

Ciurzyński¹,

Bienias²,

Irzyk³

et al. 2014

aoms

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IntroductionThere are limited data on left (LV) and right ventricular (RV) diastolic function in systemic sclerosis (SSc) patients especially in relation to biomarkers of matrix remodeling. The aim of the study was to analyze LV and RV myocardial diastolic function in SSc patients at baseline and after at least 1 year of follow-up and its relation to serum tissue inhibitors of metalloproteinase 1 (TIMP-1) level.Material and methodsWe prospectively studied 111 SSc patients (101 female, 10 male, age 54.2 ±13.8 years) and 21 age-matched controls (18 female, 3 male, age 49.3 ±10.5 years). After at least 1 year of observation (3.0 ±1.1 years) we reevaluated 69 of the SSc patients. Transthoracic echocardiography (Philips, iE33) for assessment of LV and RV diastolic function was performed and TIMP-1 serum level was measured.ResultsImpaired LV relaxation was observed in 38 (34%) SSc patients and in 1 (5%) of the controls (p < 0.001). The mean E/A ratio was lower in patients with SSc than in controls (p = 0.002) and significantly decreased after the follow-up period (p = 0.02). Impaired RV relaxation was detected in 25 (22.5%) SSc patients and in 1 (5%) control subject (p < 0.001) but did not deteriorate after follow-up. Mean serum level of TIMP-1 was significantly elevated in the follow-up group compared to baseline examination (p = 0.0001). Serum TIMP-1 level correlated positively with E/E’, both septal and lateral (r = 0.4, p = 0.002 and r = 0.32, p = 0.01).ConclusionsThe LV and RV relaxation is impaired in SSc patients. Moreover, left ventricular diastolic function deteriorated after the follow-up period. The TIMP-1 serum levels correlate with echocardiographic parameters, providing a potent link for LV diastolic function and matrix remodeling in patients with SSc.

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“…Generally, E A and E E express left ventricular dilatation function, and E A is known to be reduced [15][16][17] and E E increased [18] in systemic sclerosis patients. Diastolic dysfunction was suggested to occur due to repeated focal ischemia leading to myocardial fibrosis in systemic sclerosis [19] and induced exercise intolerance [5].…”

Section: Discussionmentioning

confidence: 99%

Pulmonary rehabilitation outcome of exercise-induced oxygen desaturation in systemic sclerosis with interstitial lung disease

Someya¹,

Mugii²

2013

Health

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While exercise capacity in systemic sclerosis with interstitial lung disease could be improved by exercise training, the training outcome of exercise-induced oxygen desaturation has not been examined. The aim of this study was to investigate the effect of pulmonary rehabilitation on exercise-induced oxygen desaturation during the six-minute walk test and to detect the factors affecting outcome retrospectively. Patients showing impaired exercise capacity (≤80% of predicted) and/or exercise-induced oxygen desaturation (≤−4% in SpO 2 ) at the end of the six-minute walk test underwent routine walking exercise. Sixteen patients with stable systemic sclerosis completed exercise training for 55 days on average. The mean six-minute walk distance improved from 467 m to 502 m (P = 0.0012). The improvement in distance was negatively related to baseline distance (R 2 = 0.28, P = 0.037), but was not related to parameters from pulmonary function tests and echocardiograms. Oxygen saturation was normal at rest, but was decreased in fifteen patients at the end of the test. Exercise-induced oxygen desaturation was positively related to the diffusion capacity of the lungs for carbon monoxide at baseline (R 2 = 0.33, P = 0.026); however, it was not related to any cardiopulmonary parameters after intervention. Seven of sixteen patients ameliorated exerciseinduced oxygen desaturation or showed no oxygen desaturation after exercise training, while others deteriorated. No cardiopulmonary parameters affected the training outcome of exercise-induced oxygen desaturation. Exercise training was beneficial in improving exercise tolerance, but training effects and mechanisms on exercise-induced oxygen desaturation still need more studies to be explained.

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Systolic and diastolic function in patients with systemic sclerosis

Cited by 27 publications

References 13 publications

Which Factors Impact Myocardial Function in Systemic Sclerosis?

Which Factors Impact Myocardial Function in Systemic Sclerosis?

Heart diastolic dysfunction in patients with systemic sclerosis

Pulmonary rehabilitation outcome of exercise-induced oxygen desaturation in systemic sclerosis with interstitial lung disease

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