Systolic and Diastolic Functional Imaging in Evaluation of Ischaemic Heart Disease

Schad, N; Bruzzone, F.; Romeo, Francisco

doi:10.1007/978-94-009-4888-4_4

Cited by 3 publications

(7 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our study group, functional images confirmed the results obtained in previous investigations [19,20,23,28], proving to be very sensitive in the detection of both CAD patients (98%) and pathological coronary regions (94%). As expected, specificity was lower, as false positive results were found in 20% of normal subjects and in 40% of normal coronary regions.…”

Section: Functional Imagessupporting

confidence: 90%

“…Although an overlapping of coronary regions is present in functional images obtained in right anterior oblique view, the morphology and location of functional abnormalities is peculiar of each region and allows the experienced investigator to correctly identify the vessel supplying the ventricular wall showing motion abnormalities [19][20][21]. Regional accuracy in the attribution of wall motion abnormalities to the 3 main coronary regions previously obtained in our laboratory was over 90%.…”

Section: Discussionmentioning

confidence: 95%

“…Functional images obtained at peak exercise were defined as pathological whenever a _> 10% regional reduction in the percentual level of the considered parameter in comparison with rest study was found. The same coronary region had to be abnormal on at least 2 functional images in order to consider it as pathological [17,19].…”

Section: Discussionmentioning

confidence: 99%

“…volume) changes in each pixel during preselected time intervals of heart cycle were visualized on numerical matrices, subsequently color-coded for easier interpretation to form parametric or socalled functional images [18]. The most useful images from a clinical point of view were previously demonstrated to be the regional ejection fraction image, the regional ejection rate image and the regional rapid filling rate image [19,20]. Normal rate images present regional temporal activity gradients in form of symmetric bands of equal range of value along the longitudinal axis of the ventricle, where the maximum (white, referring to a 10 color-coded number scale) is crescent-shaped and lies just inside the contour of the chamber.…”

Section: Data Processingmentioning

confidence: 99%

“…Normal rate images present regional temporal activity gradients in form of symmetric bands of equal range of value along the longitudinal axis of the ventricle, where the maximum (white, referring to a 10 color-coded number scale) is crescent-shaped and lies just inside the contour of the chamber. Interruption or loss of part of the normally crescent-shaped high rate band results in a net contrast between the zones with high and low rates, allowing the delineation of abnormal coronary regions with very high diagnostic sensitivity [19,20].…”

Section: Data Processingmentioning

confidence: 99%

See 4 more Smart Citations

Single-day combined evaluation of regional myocardial perfusion and function at rest and peak exercise with99mTc-MIBI in patients with coronary artery disease

et al. 1993

Self Cite

View full text Add to dashboard Cite

Abstract99mTc-labeled methoxy-isobutyl-isonitrile (MIBI) allows a simultaneous radionuclide assessment of regional heart function and perfusion. In this study the effectiveness of functional and perfusional images obtained with ~gmTc-MIBI in the detection of coronary stenoses was compared with that of their combination.We studied 197 patients who underwent coronary angiography and a single-day radionuclide protocol including first pass angiography (multicrystal gamma camera) and single photon emission computed tomography, by means of 2 injections of 99mTc-MIBI at rest and at peak exercise. Fifteen patients had < 50% stenoses, 50 had 1-vessel, 69 2-vessel and 63 3-vessel disease, for a total of 377 pathological major coronary vessels; 129 patients had previous myocardial infarction. Functional images, perfusional tomograms and their combination showed the same sensitivity (98%) and specificity (80%) in detecting coronary patients. Regional sensitivity and specificity of the combined analysis achieved 87% and 82%, respectively, vs. 94% (p < 0.005) and 60% (p < 0.001) of functional images, and 88% (p = N.S.) and 74% (p < 0.05) of perfusional tomograms.Thus, the combined analysis of regional functional and perfusional abnormalities increased significantly the specificity in the detection of coronary stenoses, in comparison with the separate evaluation of function and perfusion, achieving also a slightly higher diagnostic accuracy (85%, vs. 81% and 83%, respectively). The results confirm that a single-day protocol simultaneously assessing regional myocardial function and perfusion with 99mTc-MIBI represents a rapid and effective diagnostic method, that allows the physician to assess the presence and functional importance of coronary stenoses in less than 4 hours.

show abstract

Section: Functional Imagessupporting

confidence: 90%

Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Section: Data Processingmentioning

confidence: 99%

Section: Data Processingmentioning

confidence: 99%

See 3 more Smart Citations

Single-day combined evaluation of regional myocardial perfusion and function at rest and peak exercise with99mTc-MIBI in patients with coronary artery disease

et al. 1993

Self Cite

View full text Add to dashboard Cite

show abstract

Detection of early systolic dysfunction in ischemia by sequential radionuclide imaging of ejection rates

et al. 1994

View full text Add to dashboard Cite

The effectiveness of sequential imaging of early regional left ventricular contraction in the detection of ischemic abnormalities was assessed in 47 patients (15 with previous infarction) with angiographically proven coronary artery disease, and 11 normal volunteers, undergoing first pass radionuclide angiography with a multielement gamma camera at rest and at peak exercise. Global left ventricular hemodynamic parameters, and functional images of regional ejection fraction and ejection rate were compared to 6 pairs of sequential rate images showing the decrease and the increase of regional left ventricular volume during a time-interval of 80-280 ms (at rest) and 50-175 ms (at stress) from end-diastole. Diagnostic accuracy of sequential images (67-91%) was higher than that of ejection rate image (71-72%), and of global hemodynamic parameters (33-60%), in the detection of coronary patients. Regional sensitivity of stress sequential increase and decrease image achieved 77% and 100%, respectively. During early systole sensitivity of stress sequential increase and decrease images approached 100% even at rest, subsequently decreasing because of normalizing contraction. Thus, the analysis of early systolic dysfunction provided by dynamic sequential functional images of ejection rates proved to be an effective diagnostic tool in the detection of myocardial ischemic dysfunction.

show abstract

Single-day combined evaluation of regional myocardial perfusion and function at rest and peak exercise with99mTc-MIBI in patients with coronary artery disease

et al. 1993

View full text Add to dashboard Cite

Systolic and Diastolic Functional Imaging in Evaluation of Ischaemic Heart Disease

Cited by 3 publications

References 0 publications

Single-day combined evaluation of regional myocardial perfusion and function at rest and peak exercise with99mTc-MIBI in patients with coronary artery disease

Single-day combined evaluation of regional myocardial perfusion and function at rest and peak exercise with99mTc-MIBI in patients with coronary artery disease

Detection of early systolic dysfunction in ischemia by sequential radionuclide imaging of ejection rates

Single-day combined evaluation of regional myocardial perfusion and function at rest and peak exercise with99mTc-MIBI in patients with coronary artery disease

Contact Info

Product

Resources

About