2016
DOI: 10.1016/j.ejrad.2015.10.008
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T 1 mapping for assessment of myocardial injury and microvascular obstruction at one week post myocardial infarction

Abstract: Objectives: To compare 3T T1 mapping to conventional T2-weighted (T2W) imaging for delineating myocardial oedema one week after ST-elevation myocardial infarction (STEMI), and to explore the confounding effects of microvascular obstruction (MVO) on each technique.Methods: T2W spectral attenuated inversion recovery and native T1 mapping were applied in 10 healthy volunteers and 62 STEMI patients, and late gadolinium enhancement was included for infarct localisation at 1 week and at 6 months post-STEMI. Segmenta… Show more

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Cited by 13 publications
(11 citation statements)
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“…The increased LV mass 24 is presumably a reflection of the significant myocardial edema seen in the myocardium during the acute stage, previously reported by us and others 7,21,25 . There is extensive evidence that pre-contrast T1 mapping is reflective of edema, previously provided from our group 26 and by others [27][28][29] . Here we replicate our previous findings 7 showing that LV edema subsides in the previously well contracting segments.…”
Section: Current Results In Context Of Previous Literaturementioning
confidence: 99%
“…The increased LV mass 24 is presumably a reflection of the significant myocardial edema seen in the myocardium during the acute stage, previously reported by us and others 7,21,25 . There is extensive evidence that pre-contrast T1 mapping is reflective of edema, previously provided from our group 26 and by others [27][28][29] . Here we replicate our previous findings 7 showing that LV edema subsides in the previously well contracting segments.…”
Section: Current Results In Context Of Previous Literaturementioning
confidence: 99%
“…The advent of quantitative tissue characterization of the myocardium, with its promise for prognostic and diagnostic value in a plethora of cardiomyopathies, has spiked great research interest and has triggered a large number of clinical studies . Available tools for MR‐based quantitative tissue characterization in the heart include perfusion ; T 1 , T 2 , and normalT2* relaxation mapping techniques ; and a combination thereof .…”
Section: Introductionmentioning
confidence: 99%
“…A plot of ECV for three post contrast blood T1 s and a post-contrast myocardial T1 of 300 ms shows the weak dependence on T1 m0 (Additional file 1 ). A highly realistic scenario in which the native T1 in regions of edema are elevated by 100 ms [ 53 , 54 ], from 1150 to 1250, results in an absolute deviation of ECV by +0.02 (+2%), when ECV is measured with T1 b = 350 ms, for any myocardial post-contrast T1. This absolute increase in ECV by 2% cannot be measured if T1 m0 is assumed constant at 1150 ms.…”
Section: Methodsmentioning
confidence: 99%