T- and B-Lymphocyte Subsets in Patients with Dupuytren’s Disease

Guðmundsson, Kristján G.; Arngrı́msson, Reynir; Arinbjarnarson, Sturla; Ólafsson, Andri; Jónsson, Þorbjörn

doi:10.1016/s0266-7681(98)80083-1

Cited by 26 publications

(17 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…We focused on 44 of the autoimmune diseases mentioned in Harrison's Principles of Internal Medicine (19, 20), plus amyotrophic lateral sclerosis and Dupuytren's contracture (Table 2). Although not conventionally categorized as autoimmune, the latter 2 diseases were included on the basis of literature indicating that an autoimmune pathogenesis might be involved (21–24). For type 1 diabetes mellitus, the observation period started in 1987, because before then ICD‐8 codes did not distinguish between insulin‐dependent and non–insulin‐dependent diabetes mellitus.…”

Section: Methodsmentioning

confidence: 99%

Autoimmune diseases in women with Turner's Syndrome

Jørgensen¹,

Rostgaard²,

Bache³

et al. 2010

Arthritis & Rheumatism

158

135

View full text Add to dashboard Cite

Objective. In terms of number of X chromosomes, women with Turner's syndrome cytogenetically resemble men. An increased risk of autoimmune diseases has been observed among women with Turner's syndrome. This study was undertaken to investigate whether the autoimmune disease profile in women with Turner's syndrome is characterized by diseases with a female or male predominance. Results. The overall risk of autoimmune disease among women with Turner's syndrome was twice that among Danish women in general (SIR 2.1 [95% CI 1.6-2.7]). For autoimmune diseases with a female predominance, the SIR among women with Turner's syndrome was 1.7 (95% CI 1.2-2.4), whereas the SIR for autoimmune diseases with a male predominance among these women was 3.9 (95% CI 2.5-5.8). Associations were strongest for Hashimoto thyroiditis (SIR 14.6 [95% CI 6.7-27.1]), a strongly female-predominant condition, and type 1 diabetes mellitus (SIR 4.1 [95% CI 2.5-6.3]). Methods. Using the Danish Cytogenetic CentralConclusion. Women with Turner's syndrome are at excess risk of autoimmune diseases, notably autoimmune diseases characterized by male predominance.

show abstract

Section: Methodsmentioning

confidence: 99%

Autoimmune diseases in women with Turner's Syndrome

Jørgensen¹,

Rostgaard²,

Bache³

et al. 2010

Arthritis & Rheumatism

158

135

View full text Add to dashboard Cite

show abstract

“…Previous reports have indicated that inflammatory mechanisms may be involved in the pathogenesis of Dupuytren's disease and it has even been suggested that this condition is a T-cell-mediated autoimmune phenomenon. Gudmundsson et al 59 investigated subsets of peripheral blood lymphocytes from 21 patients and compared them with those of ten healthy blood donors and found that the Dupuytren patients had an increase in DR+ T-cells when compared with the control group. They considered that these findings support previous suggestions that immunological mechanisms, involving activated T-cells and probably also B-cells, are involved in the pathogenesis of Dupuytren's disease.…”

Section: Manipulation Of the Controls The Work On Interferon Bymentioning

confidence: 99%

Dupuytren’s Disease

Thurston¹

2003

The Journal of Bone and Joint Surgery. British volume

View full text Add to dashboard Cite

“…DD is thought to arise either from a defect in the wound repair process or from an abnormal response to wounding. The presence of immune cells and related phenomena in DD tissue suggests DD may be immune-related [50-53]. Cellularity (quantified as the cellular density) of the DD nodules (see below) is indicative of the activity of the disease [4].…”

Section: Dupuytren's Disease and Its Many Facesmentioning

confidence: 99%

Dupuytren's: a systems biology disease

et al. 2011

View full text Add to dashboard Cite

Dupuytren's disease (DD) is an ill-defined fibroproliferative disorder of the palm of the hands leading to digital contracture. DD commonly occurs in individuals of northern European extraction. Cellular components and processes associated with DD pathogenesis include altered gene and protein expression of cytokines, growth factors, adhesion molecules, and extracellular matrix components. Histology has shown increased but varying levels of particular types of collagen, myofibroblasts and myoglobin proteins in DD tissue. Free radicals and localised ischaemia have been suggested to trigger the proliferation of DD tissue. Although the existing available biological information on DD may contain potentially valuable (though largely uninterpreted) information, the precise aetiology of DD remains unknown. Systems biology combines mechanistic modelling with quantitative experimentation in studies of networks and better understanding of the interaction of multiple components in disease processes. Adopting systems biology may be the ideal approach for future research in order to improve understanding of complex diseases of multifactorial origin. In this review, we propose that DD is a disease of several networks rather than of a single gene, and show that this accounts for the experimental observations obtained to date from a variety of sources. We outline how DD may be investigated more effectively by employing a systems biology approach that considers the disease network as a whole rather than focusing on any specific single molecule.

show abstract

T- and B-Lymphocyte Subsets in Patients with Dupuytren’s Disease

Cited by 26 publications

References 15 publications

Autoimmune diseases in women with Turner's Syndrome

Autoimmune diseases in women with Turner's Syndrome

Dupuytren’s Disease

Dupuytren's: a systems biology disease

Contact Info

Product

Resources

About