T and B lymphocyte subsets in fenoprofen nephropathy

Stachura, Irene; Jayakumar, Subramoniam; Bourke, E.

doi:10.1016/0002-9343(83)91161-0

Cited by 56 publications

(13 citation statements)

References 30 publications

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“…Another difference was the nature of the inflammatory infiltrate in the tubulointerstitial nephritis. In most human cases, the infiltrate consists primarily of lymphocytes, although infiltrates that include neutrophils and eosinophils have been described (5,23,34,50 (47). In humans, the recommended prescription dose of naproxen is 1,000 mg/day divided into 2 doses (15-20 mg/kg/day), although 1,500 mg/day (20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30) mg/kg/ day) may be used for 2 wk (36,52), and 1,800 mg/day of naproxen was administered for 1 mo without any side effects (48).…”

Section: Discussionmentioning

confidence: 99%

Renal Changes Associated with Naproxen Sodium Administration in Cynomolgus Monkeys

Leach¹,

Frank²,

Berardi³

et al. 1999

Toxicol Pathol

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Naproxen sodium was administered to cynomolgus monkeys (Macaca fascicularis) by oral gavage at daily doses of 44, 88, or 176 mg/kg for 2 wk (2 monkeys/gender) or of 44 mg/kg for 13 wk (4 monkeys/gender). Body weight loss occurred in at least one monkey in all naproxen sodium-dosed groups in the 2-wk (up to 16% loss) and 13-wk (up to 22% loss) studies. Increases in plasma naproxen concentrations were dose proportional between 44 and 88 mg/kg but were less than dose proportional between 88 and 176 mg/kg. Up to 2-fold increases in creatinine and/or serum urea nitrogen values as well as higher renal weights occurred in monkeys receiving 176 mg/kg for 2 wk or 44 mg/kg for 13 wk. Microscopically, renal changes were observed in all naproxen sodium-dosed groups. Renal findings after 2 wk of exposure included increased interstitial ground substance, tubular dilatation, and tubulointerstitial nephritis; in the 13-wk study, cortical tubular atrophy and interstitial fibrosis were also observed. These studies identify the kidney as the target organ of naproxen sodium in cynomolgus monkeys.

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Section: Discussionmentioning

confidence: 99%

Renal Changes Associated with Naproxen Sodium Administration in Cynomolgus Monkeys

Leach¹,

Frank²,

Berardi³

et al. 1999

Toxicol Pathol

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“…The infiltrates had a preponderance of T lymphocytes (7)(8)(9). The reported cases were all apparent idiosyncratic drug reactions.…”

Section: Pathogenesismentioning

confidence: 83%

Minimal-Change Glomerulopathy and Glomerular Visceral Epithelial Hyperplasia Associated with Alpha-lnterferon Therapy for Cutaneous T-Cell Lymphoma

Traynor¹,

Kuzel²,

Samuelson³

et al. 1994

Nephron

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A 44-year-old man was diagnosed with cutaneous T-cell lymphoma characterized by a proliferation of CD4-positive cells. In response to α-interferon therapy, he experienced rapid regression of his cutaneous disease. This improvement was associated with development of renal failure, characterized by nephrotic-range proteinuria with interstitial nephritis and minimal-change nephropathy. The remarkable finding of renal biopsy was marked proliferation of visceral epithelial cells (podocytes). Renal disease improved significantly in response to discontinuation of interferon and initiation of prednisone therapy. Nephrotic range proteinuria regressed, but never completely resolved. This case is illustrative of the probable role for lymphokine-mediated nephrotoxicity in the setting of lymphoproliferative disease.

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“…The lymphocytic infiltrate (predominantly cytotoxic/suppressor T cells), lack of deposition of immu-noreactants in the renal biopsy and absence of systemic manifestations of an allergic reaction suggests a delayedtype hypersensitivity [12]. Tissue eosinophilia, though frequent, is a finding in a number of pathologic processes and may not be specific for an immediate hypersensitiv ity as the primary mechanism of this disease [13].…”

Section: Discussionmentioning

confidence: 99%