T-antigen binding lectin with antibacterial activity from marine invertebrate, sea cucumber (Holothuria scabra): Possible involvement in differential recognition of bacteria

Gowda, Nagaraj; Goswami, U.; Khan, Mubbsher Munawar

doi:10.1016/j.jip.2008.04.003

Cited by 61 publications

(38 citation statements)

References 21 publications

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“…Their levels were upregulated in the virulent experiment from day 6 to 12, plateaued on day 15 (when the tank temperature reached 32.5°C) and then returned to the control level by day 18 (Fig.6Ai,ii). This transcriptional induction is not surprising, as lectin-like genes have been found to be induced in a large set of studies on experimental infections of invertebrate species (O'Rourke et al, 2006;Huang et al, 2007;Gowda et al, 2008;Soonthornchai et al, 2010;Zhang et al, 2010). The day 18 decrease is more surprising, but many coral cells were undergoing necrosis at this stage (Fig.1).…”

Section: Discussionmentioning

confidence: 75%

Physiological responses of the scleractinian coral Pocillopora damicornis to bacterial stress from Vibrio coralliilyticus

Vidal-Dupiol

Ladrière

Meistertzheim

et al. 2011

Journal of Experimental Biology

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SUMMARYAs the effects of climate change have become increasingly visible over the past three decades, coral reefs have suffered from a number of natural and anthropogenic disturbances that have caused a critical decline in coral populations. Among these disturbances are coral diseases, which have appeared with increasing frequency and severity, often in correlation with increases in water temperature. Although the crucial role played by Vibrio species in coral disease has been widely documented, the scientific community does not yet fully understand the infection process of Vibrio or its impact on coral physiology and immunology. Here, we investigated the physiological and transcriptomic responses of a major reef-building coral, Pocillopora damicornis, when exposed to a specific pathogen (Vibrio coralliilyticus) under virulent (increasing water temperature) and nonvirulent (constant low temperature) conditions. The infection process was examined by electron microscopy and quantitative reverse-transcription PCR, and coral health was monitored by visual observations and measurements of zooxanthellar density. The results obtained suggest that coral tissue invasion occurs upon increasing water temperature only. Transcriptomic variations were investigated using a suppression-subtractive-hybridization approach, and the expression levels of six candidate immunerelated genes were examined during bacterial exposure. These genes correspond to three lectin-like molecules putatively involved in the recognition of pathogens, two metal-binding proteins putatively involved in antibacterial response and one cystein protease inhibitor. The transcription patterns of these selected genes provide new insights into the responses of coral colonies to virulent versus non-virulent bacteria. Supplementary material available online at

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Section: Discussionmentioning

confidence: 75%

Physiological responses of the scleractinian coral Pocillopora damicornis to bacterial stress from Vibrio coralliilyticus

Vidal-Dupiol

Ladrière

Meistertzheim

et al. 2011

Journal of Experimental Biology

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“…Maltseva and co-workers also found that two other peptides were fragments of actin, while one peptide was a fragment of filamin A. Gowda et al (2008) showed that an agglutinin that can agglutinate Gram-positive and Gram-negative bacteria exhibited strong antibacterial activity both under in vivo and in vitro conditions. Defensinlike peptides were isolated by Ng et al (2013) in Strongylocentrotus droebachiensis.…”

Section: Antimicrobial and Antibiofilm Peptides In Echinodermsmentioning

confidence: 96%

Antimicrobial peptides from echinoderms as antibiofilm agents: a natural strategy to combat bacterial infections

Schillaci

Cusimano

Russo

et al. 2014

Italian Journal of Zoology

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“…The antibacterial activity has previously been described in some species of echinoderms (Gowda et al 2008;Haug et al 2002;Kazemi et al 2016;Kiani et al 2014;Ridzwan et al 1995). Haug et al (2002) studied the antibacterial activity of different parts of the green sea urchin Strongylocentrotus droebachiensis (Müller, 1776), the common starfish Asterias rubens (Linnaeus, 1758) and the sea cucumber Cucumaria frondosa .…”

Section: Antibacterial Effects Of the Extractsmentioning

confidence: 99%

“…The sea cucumbers have multiple biological activities such as wound healing (Fredalina et al 1999), antibacterial (Gowda et al 2008;Haug et al 2002;Kiani et al 2014;Ridzwan et al 1995), antifungal (Wang et al 2012), agglutinating activities (De Melo et al 2014;Gowda et al 2008) and antioxidant properties (Osama et al 2009). …”

mentioning

confidence: 99%

Bioactivity of aqueous and organic extracts of sea cucumber Holothuria leucospilota (Brandt 1835) on pathogenic Candida and Streptococci

et al. 2018

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Holothurians (sea cucumbers) exist almost in all benthic marine environments and they are an important species for the commercial fisheries. In this study, the antimicrobial activity of different tissues of the sea cucumber, as a marine invertebrate, was investigated. The bacteria, Streptococcus mutans and Streptococcus sobrinus, the fungi, Candida parapsilosis, Candida albicans and Candida glabrata, were chosen for antimicrobial test, because they are opportunistic pathogens. The body wall, respiratory tree, and gastrointestinal tract of the sea cucumbers were utilized to make the extracts. Phosphate-buffered saline (PBS), ethanol (Et), and acetonitrile (ACN) were used as solvents for aqueous and organic extractions. The results showed that there were antimicrobial active compounds against infective streptococci and candid fungi. Streptococcus mutans was generally more tolerant than Streptococcus sobrinus to the sea cucumber extracts. The extracts of the respiratory tree with ACN and PBS, as solvents, showed the highest effect against Candida albicans, Candida parapsilosis and Candida glabrata. The extracts of gastrointestinal tract and the body wall with Et and PBS, respectively, had not any antifungal activity. The antimicrobial activities had been found in different extracts of the sea cucumber tissues, which could be related to the protein and non-protein compounds.

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T-antigen binding lectin with antibacterial activity from marine invertebrate, sea cucumber (Holothuria scabra): Possible involvement in differential recognition of bacteria

Cited by 61 publications

References 21 publications

Physiological responses of the scleractinian coral Pocillopora damicornis to bacterial stress from Vibrio coralliilyticus

Physiological responses of the scleractinian coral Pocillopora damicornis to bacterial stress from Vibrio coralliilyticus

Antimicrobial peptides from echinoderms as antibiofilm agents: a natural strategy to combat bacterial infections

Bioactivity of aqueous and organic extracts of sea cucumber Holothuria leucospilota (Brandt 1835) on pathogenic Candida and Streptococci

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