T cell immunotherapy for cervical cancer: challenges and opportunities

Yu, Lingfeng; Lanqing, Gong; Huang, Ziyu; Xin, Xiaoyan; Mao, Liang; Fa-hui, Lv; Zou, Hongmei; Min, Jie

doi:10.3389/fimmu.2023.1105265

Cited by 12 publications

(4 citation statements)

References 89 publications

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“…Further, chimeric antigen receptor T-cells (CAR-T) therapy has demonstrated reliable results in preliminary clinical trials for HPV-associated cancers [165,166]. Finally, adoptive transfer techniques to introduce tumorinfiltrating lymphocytes and HPV-targeted T-cells directly into the TME have shown promising results in treating HPV-related cancers.…”

Section: Ebvmentioning

confidence: 99%

“…Finally, adoptive transfer techniques to introduce tumorinfiltrating lymphocytes and HPV-targeted T-cells directly into the TME have shown promising results in treating HPV-related cancers. These studies have demonstrated the potential of the adoptive transfer of tumorinfiltrating lymphocytes, leading to the regression of HPVpositive tumors in cervical and epithelial cancers [166,167]. Similarly, ongoing clinical trials are being conducted for adoptive cell transfer of EBV-tumor cell receptor T-cells (NCT03648697) capable of directing robust anti-tumor activity within the TME.…”

Section: Ebvmentioning

confidence: 99%

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Beyond Viral Infections: The Multifaceted Roles of Human Papillomavirus and Epstein-Barr Virus in Shaping the Tumor Microenvironment

Fernandes,

Sher,

Prabhu

et al. 2024

Discovery Medicine

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The tumor microenvironment (TME) exerts a profound influence on the oncogenesis and progression of various cancers, notably those instigated by the human papillomavirus (HPV) and the Epstein-Barr virus (EBV). The etiology of HPV and EBV-associated malignancies is rooted in intricate interactions that intertwine viral infections, genetic predispositions, and distinct TME dynamics. These interactions foster a milieu that can either support or hinder tumorigenic progression. Gaining in-depth knowledge of the TME's unique features, including its cellular composition, cytokine profiles, and metabolic alterations specific to HPV and EBV-associated cancers, is fundamental to innovating more efficacious therapeutic strategies. This review delineates the intricate roles of HPV and EBV in shaping the TME and expounds upon the unique TME characteristics specific to HPV and EBV-driven cancers. Additionally, we spotlight innovative approaches to remodel the TME, aiming to augment therapeutic efficacy in combatting HPV and EBV-associated neoplasms.

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Section: Ebvmentioning

confidence: 99%

Section: Ebvmentioning

confidence: 99%

Beyond Viral Infections: The Multifaceted Roles of Human Papillomavirus and Epstein-Barr Virus in Shaping the Tumor Microenvironment

Fernandes,

Sher,

Prabhu

et al. 2024

Discovery Medicine

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“…These challenges are primarily attributed to the immunosuppressive nature of the tumor microenvironment and the paucity of tumor-specific antigens that can be targeted [208]. As a result of the above-mentioned constraints, clinical investigations of CAR-based cell therapy for cervical cancer remain relatively limited (Table 4) [209]. Currently, only a few clinical studies have been dedicated to this specific application.…”

Section: Engineered T-cell Therapymentioning

confidence: 99%

Epigenetic and Genetic Keys to Fight HPV-Related Cancers

Folliero,

Dell’Annunziata,

Chianese

et al. 2023

Cancers

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Cervical cancer ranks as the fourth most prevalent cancer among women globally, with approximately 600,000 new cases being diagnosed each year. The principal driver of cervical cancer is the human papillomavirus (HPV), where viral oncoproteins E6 and E7 undertake the role of driving its carcinogenic potential. Despite extensive investigative efforts, numerous facets concerning HPV infection, replication, and pathogenesis remain shrouded in uncertainty. The virus operates through a variety of epigenetic mechanisms, and the epigenetic signature of HPV-related tumors is a major bottleneck in our understanding of the disease. Recent investigations have unveiled the capacity of viral oncoproteins to influence epigenetic changes within HPV-related tumors, and conversely, these tumors exert an influence on the surrounding epigenetic landscape. Given the escalating occurrence of HPV-triggered tumors and the deficiency of efficacious treatments, substantial challenges emerge. A promising avenue to address this challenge lies in epigenetic modulators. This review aggregates and dissects potential epigenetic modulators capable of combatting HPV-associated infections and diseases. By delving into these modulators, novel avenues for therapeutic interventions against HPV-linked cancers have come to the fore.

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“…As for ACT, studies use tumor-infiltrating lymphocytes (TILs) and T cells directed to HPV. TILs have shown promising results in treating advanced HPV+ cervical cancers [ 195 , 196 ]. In a phase II study, the adoptive transfer of TILs mediated the regression of lesions in HPV-associated epithelial cancers [ 186 ].…”

Section: Cell Therapy For Hpv+ Cancersmentioning

confidence: 99%

Advancing Immunotherapies for HPV-Related Cancers: Exploring Novel Vaccine Strategies and the Influence of Tumor Microenvironment

et al. 2023

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The understanding of the relationship between immunological responses and cancers, especially those related to HPV, has allowed for the study and development of therapeutic vaccines against these neoplasias. There is a growing number of studies about the composition and influence of the tumor microenvironment (TME) in the progression or establishment of the most varied types of cancer. Hence, it has been possible to structure immunotherapy approaches based on therapeutic vaccines that are even more specific and directed to components of TME and the immune response associated with tumors. Among these components are dendritic cells (DCs), which are the main professional antigen-presenting cells (APCs) already studied in therapy strategies for HPV-related cancers. On the other hand, tumor-associated macrophages are also potential targets since the profile present in tumor infiltrates, M1 or M2, influences the prognosis of some types of cancer. These two cell types can be targets for therapy or immunomodulation. In this context, our review aims to provide an overview of immunotherapy strategies for HPV-positive tumors, such as cervical and head and neck cancers, pointing to TME immune cells as promising targets for these approaches. This review also explores the potential of immunotherapy in cancer treatment, including checkpoint inhibitors, cytokine immunotherapies, immunotherapy vaccines, and cell therapies. Furthermore, it highlights the importance of understanding the TME and its effect on the design and achievement of immunotherapeutic methods.

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T cell immunotherapy for cervical cancer: challenges and opportunities

Cited by 12 publications

References 89 publications

Beyond Viral Infections: The Multifaceted Roles of Human Papillomavirus and Epstein-Barr Virus in Shaping the Tumor Microenvironment

Beyond Viral Infections: The Multifaceted Roles of Human Papillomavirus and Epstein-Barr Virus in Shaping the Tumor Microenvironment

Epigenetic and Genetic Keys to Fight HPV-Related Cancers

Advancing Immunotherapies for HPV-Related Cancers: Exploring Novel Vaccine Strategies and the Influence of Tumor Microenvironment

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