T-Cell Lymphopenia in Patients with Advanced Thyroid Carcinoma Is Associated with Poor Prognosis

Rabold, Katrin; Gielen, Paul R.; Kers‐Rebel, Esther D.; Netea, Mihai G.; Smit, J.W.A.; Adema, Gosse J.; Netea‐Maier, Romana T.

doi:10.1634/theoncologist.2018-0422

Cited by 4 publications

(4 citation statements)

References 14 publications

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“…PRDM1 is associated with overall survival of TC patients [ 29 ]. The percentage of CD4+ T cells is lower in patients with advanced metastatic TC [ 30 ]. ENTPD1 is highly expressed in TC, and high expression of ENTPD1contributs to the prognosis of TC patients [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

TIM3 activates the ERK1/2 pathway to promote invasion and migration of thyroid tumors

Jin,

Yin,

et al. 2024

PLoS ONE

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Background This study aims to study the possible action mechanism of T-cell immunoglobulin and mucin domain 3 (TIM3) on the migratory and invasive abilities of thyroid carcinoma (TC) cells. Methods GSE104005 and GSE138198 datasets were downloaded from the GEO database for identifying differentially expressed genes (DEGs). Functional enrichment analysis and protein-protein interaction (PPI) analysis were performed on the common DEGs in GSE104005 and GSE138198 datasets. Subsequently, in order to understand the effect of a common DEG (TIM3) on TC cells, we performed in vitro experiments using FRO cells. The migratory and invasive abilities of FRO cells were detected by wound scratch assay and Transwell assay. Proteins expression levels of the phosphorylated (p)-extracellular signal-regulated kinase (ERK)1/2, matrix metalloproteinase-2 (MMP-2) and MMP-9 were determined via Western blotting after ERK1/2 inhibition in TIM3-NC group and TIM3-mimic group. Results 316 common DEGs were identified in GSE104005 and GSE138198 datasets. These DEGs were involved in the biological process of ERK1 and ERK2 cascade. TIM3 was significantly up-regulated in TC. In vitro cell experiments showed that TIM3 could promote migration and invasion of TC cells. Moreover, TIM3 may affect the migration, invasive abilities of TC cells by activating the ERK1/2 pathway. Conclusion The above results indicate that TIM3 may affect the migratory and invasive of TC cells by activating the ERK1/2 pathway.

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Section: Discussionmentioning

confidence: 99%

TIM3 activates the ERK1/2 pathway to promote invasion and migration of thyroid tumors

Jin,

Yin,

et al. 2024

PLoS ONE

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“…Rabold’s study proposed that T lymphocytopenia was associated with a poor prognosis in patients with advanced thyroid cancer. 20 Teck Seo’s study reported that chemotherapy-related lymphocytopenia was an independent prognostic factor for adjuvant chemotherapy after potentially curative surgery in colorectal cancer patients. 21 In our study, multivariate analysis revealed that preoperative ALC and histological subtype were predictive markers of LRFS in NSCLS.…”

Section: Discussionmentioning

confidence: 99%

Nomogram Based on Preoperative Absolute Lymphocyte Count to Predict Local Recurrence in Patients with Non-Small Cell Lung Cancer After Microwave Ablation

Lv¹,

Liu²,

Li³

et al. 2023

JIR

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Purpose This study aims to investigate the prognostic value of preoperative absolute lymphocyte count (preALC) for non-small cell lung cancer (NSCLC) after microwave ablation (MWA) and build a combined nomograph with clinical features to predict the local recurrence. Patients and Methods A total of 118 NSCLC patients who underwent microwave ablation were enrolled in this study. The median local recurrence-free survival (LRFS) was 35.5 months. Independent prognostic factors obtained by multivariate analysis were included in the prediction model. The prognostic value of the model was assessed by the area under the time-dependent receiver operating characteristic curve (T-AUC). Results Histological subtype and preALC were independent risk factors for local relapse-free survival. According to the time-dependent receiver operating characteristic curve (T-ROC), the optimal cut-off value of preALC was 1.965×10 9 /L, the sensitivity was 0.837, and the specificity was 0.594. The area under the T-ROC curve (AUC) of preALC was 0.703. To establish a nomogram to predict the local recurrence rate of NSCLC after MWA based on the prognostic factors revealed by Cox regression. Conclusion Preoperative lymphocyte count reduction is associated with poor prognosis of NSCLC. The nomogram model combined with preALC can provide a good individualized prediction of local recurrence after microwave ablation.

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“…A recent work by Rabold et al. ( 43 ) found that T-cell lymphopenia in patients with thyroid cancer indicates an aggressive tumor behavior and might badly influence the outcome of the disease. Lymphopenia could play a role also for persistent infections by oncogenic viruses.…”

Section: Discussionmentioning

confidence: 99%

“…Generally, there is limited understanding regarding the relationship between the development of thyroid adenomas or carcinomas and lymphopenia. A recent work by Rabold et al (43) found that T-cell lymphopenia in patients with thyroid cancer indicates an aggressive tumor behavior and might badly influence the outcome of the disease. Lymphopenia could play a role also for persistent infections by oncogenic viruses.…”

Section: Discussionmentioning

confidence: 99%

Risk of thyroid neoplasms in patients with 22q11.2 deletion and DiGeorge-like syndromes: an insight for follow-up

et al. 2023

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IntroductionThe chromosome 22q11.2 deletion syndrome comprises phenotypically similar diseases characterized by abnormal development of the third and fourth branchial arches, resulting in variable combinations of congenital heart defects, dysmorphisms, hypocalcemia, palatal dysfunction, developmental or neuropsychiatric disorders, and impairment of the immune system due to thymic dysfunction. Other genetic syndromes, often called DiGeorge-like, share clinical and immunological features with 22q11.2 deletion syndrome. This syndrome has been rarely associated with malignancies, mainly hematological but also hepatic, renal, and cerebral. Rarely, malignancies in the head and neck region have been described, although no aggregate of data on the development of thyroid neoplasms in patients with this clinical phenotype has been conducted so far.Materials and methodsTo characterize this possible association, a multicenter survey was made. Thus, we present a case series of five pediatric patients with 22q11.2 deletion syndrome or DiGeorge-like syndrome who were occasionally found with confirmed or highly suspected neoplasms of the thyroid gland during their follow-up. In three cases, malignancies were histologically confirmed, but their outcome was good due to an early recognition of suspicious nodules and precocious surgery.ConclusionsThis study underlines for clinicians the higher risk of neoplasms in the head and neck district for patients affected by these syndromes. It also emphasizes the importance of a prolonged clinical and ultrasound follow-up for patients with this clinical and immunological phenotype.

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T-Cell Lymphopenia in Patients with Advanced Thyroid Carcinoma Is Associated with Poor Prognosis

Cited by 4 publications

References 14 publications

TIM3 activates the ERK1/2 pathway to promote invasion and migration of thyroid tumors

TIM3 activates the ERK1/2 pathway to promote invasion and migration of thyroid tumors

Nomogram Based on Preoperative Absolute Lymphocyte Count to Predict Local Recurrence in Patients with Non-Small Cell Lung Cancer After Microwave Ablation

Risk of thyroid neoplasms in patients with 22q11.2 deletion and DiGeorge-like syndromes: an insight for follow-up

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