T cell profiles in vitiligo

Evaluation of Histologically and Histochemically Proven Cases of Vitiligo and its Correlation with CD4+ and CD8+ Lymphocyte Counts using Flow Cytometry

“…CD4+:CD8+ ratio was found to be statistically significant decreased in vitiligo patients as compared with the control group with p-value<0.001 which is less than 0.05. These findings were consistent with the previous studies done by Grimes PE et al, in 1986 [ Table/ In this control subject CD4+ counts are greater as compared to CD4+ counts leading to normal CD4+:CD8+ ratio.…”

Redução dos linfócitos T-CD8+ citotóxicos observada com a terapia Puva em paciente com vitiligo

“…[8][9][10] No caso aqui relatado de forma original, avaliou-se o efeito de intervenção (terapia Puva) sobre esses linfócitos. A relação CD4/CD8 encontrada foi elevada antes (3,02) e após o tratamento (3,68).…”

A Double-blind Randomized Trial of 0.1% Tacrolimus vs 0.05% Clobetasol for the Treatment of Childhood Vitiligo

“…6 However, experimental evidence shows that abnormal humoral and cellmediated immune mechanisms are probably the most commonly involved aspect of pathogenesis in this disease. [7][8][9][10] The relative success of clinical use of topical corticosteroids (a widespread therapeutic approach with response rates between 50% and 70%) supports this theory. 11 Tacrolimus is an immunosuppressor macrolide lactone capable of inhibiting the activation and maturation of T cells by means of blocking the action of calcineurin and interleukin (IL) 2, IL-4, and IL-5 transcription.…”