T cell receptor (TCR) interaction with haptens: metal ions as non-classical haptens

Thierse, Hermann‐Josef; Gamerdinger, K.; Junkes, Christof; Guerreiro, Nelson; Weltzien, Hans Ulrich

doi:10.1016/j.tox.2004.12.015

Cited by 138 publications

(120 citation statements)

References 27 publications

Supporting

Mentioning

114

Contrasting

Unclassified

Order By: Relevance

“…Ni ions (Ni 2+ ) released from various alloys are potent allergens or haptens that can trigger inflammation of the skin (10)(11)(12). Ni 2+ penetrates the skin and activates epithelial cells that produce cytokines or chemokines following hyperreactive immune responses involving the activation of APCs and T cells (13)(14)(15).…”

mentioning

confidence: 99%

A Critical Role for Thymic Stromal Lymphopoietin in Nickel-Induced Allergy in Mice

Ashrin

Arakaki

Yamada

et al. 2014

The Journal of Immunology

View full text Add to dashboard Cite

Ni is the most frequent cause of contact allergy induced by metals. However, the underlying mechanism of this induction is unknown. Our previous research demonstrates that activation of dendritic cells (DCs) through p38MAPK/MKK6 is required for Ni-induced allergy in mice. In the current study, we investigated the cellular and molecular mechanisms underlying Ni-induced allergy using a mouse model that involves injecting Ni into the ear, with or without Freund’s incomplete or complete adjuvants. Nickel had greater potential to cause allergic reactions compared with palladium and gold. Among the proteins expressed at higher levels in mice with Ni-induced allergy, we focused on thymic stromal lymphopoietin (TSLP), which is produced in abundance by keratinocytes. We detected increased expression of the TSLP receptor (TSLPR) in DCs from cervical lymph nodes of mice with Ni-induced allergy, suggesting that DCs in ear tissues were activated through TSLPR signaling induced by keratinocyte-derived TSLP. Furthermore, delayed-type hypersensitivity reactions in mice with Ni-induced allergy were decreased significantly by injection of a Tslp–short interfering RNA along with atelocollagen in the ear skin. These results suggest that Ni allergy may be triggered by a TSLP/TSLPR-mediated interaction between epithelial and immune cells.

show abstract

mentioning

confidence: 99%

A Critical Role for Thymic Stromal Lymphopoietin in Nickel-Induced Allergy in Mice

Ashrin

Arakaki

Yamada

et al. 2014

The Journal of Immunology

View full text Add to dashboard Cite

show abstract

“…T-cell epitopes are generated efficiently via processing of chemically modified proteins by antigen-presenting cells (APC) such as DC to produce chemically modified peptides presented on MHC molecules to T cells or by direct modification of MHC-bound peptides. Our molecular understanding of the interaction of the T-cell receptor (TCR) with chemicals presented in the context of MHC molecules has significantly increased [24][25][26]. We now know that some protein-reactive organic chemicals, classical haptens, are recognized by T cells as covalently hapten-modified MHC-bound peptides [27][28][29][30][31][32].…”

Section: Replacement Of Animal Testing: T Cells As Tools In Immunotoxmentioning

confidence: 99%

“…In the 1990s the molecular basis for T-cell recognition of chemicals became clear [24][25][26]. Efforts were made to study primary human T-cell responses to chemicals.…”

Section: Replacement Of Animal Testing: T Cells As Tools In Immunotoxmentioning

confidence: 99%

T-cell recognition of chemicals, protein allergens and drugs: towards the development of in vitro assays

Martin

Esser

Schmucker

et al. 2010

Cell. Mol. Life Sci.

Self Cite

133

View full text Add to dashboard Cite

Chemicals can elicit T-cell-mediated diseases such as allergic contact dermatitis and adverse drug reactions. Therefore, testing of chemicals, drugs and protein allergens for hazard identification and risk assessment is essential in regulatory toxicology. The seventh amendment of the EU Cosmetics Directive now prohibits the testing of cosmetic ingredients in mice, guinea pigs and other animal species to assess their sensitizing potential. In addition, the EU Chemicals Directive REACh requires the retesting of more than 30,000 chemicals for different toxicological endpoints, including sensitization, requiring vast numbers of animals. Therefore, alternative methods are urgently needed to eventually replace animal testing. Here, we summarize the outcome of an expert meeting in Rome on 7 November 2009 on the development of T-cell-based in vitro assays as tools in immunotoxicology to identify hazardous chemicals and drugs. In addition, we provide an This article is dedicated to the memory of our colleague and friend Reinhard Wanner, died 2 April 2010. Cellular and Molecular Life Sciences overview of the development of the field over the last two decades.

show abstract

“…158 For activation of hapten-specific TL without antigen processing, the T cell receptor needs to approximate the MHC molecule of the antigen-presenting cell. This proximity forms a binding site with high affinity for nickel, which binds and stabilizes the complex by activating the T cell 153 …”

Section: Mechanism Of Allergic Contact Dermatitis By Transition Metalsmentioning

confidence: 99%

Imunopatologia da dermatite de contato alérgica

Martins

Reis

2011

An. Bras. Dermatol.

View full text Add to dashboard Cite

Allergic contact dermatitis is the consequence of an immune reaction mediated by T cells against low molecular weight chemicals known as haptens. It is a common condition that occurs in all races and age groups and affects the quality of life of those who present it. The immunological mechanism of this disease has been reviewed in recent decades with significant advance in its understanding. The metabolism and pathway of the haptens as well as the activation and mechanism of action of the cells responsible for both the immune reaction and its completion are discussed in this article. Keywords: Allergy and immunology; Dermatitis, allergic contact; Dermatitis, contact; Hypersensitivity Resumo: A dermatite de contato alérgica é consequência de uma reação imune mediada por células T contra químicos de baixo peso molecular, denominados haptenos. É uma condição frequente que ocorre em todas as raças e faixas etárias e afeta a qualidade de vida de seus portadores. O mecanismo imunológico desta doença vem sendo revisto nas últimas décadas com significativo avanço no seu entendimento. A metabolização e o caminho dos haptenos, bem como a formação e o mecanismo de ação das células responsáveis tanto pela reação quanto pelo seu término, são discutidos neste artigo. Palavras-chave: Alergia e imunologia; Hipersensibilidade; Dermatite de contato; Dermatites alérgicas de contato

show abstract

T cell receptor (TCR) interaction with haptens: metal ions as non-classical haptens

Cited by 138 publications

References 27 publications

A Critical Role for Thymic Stromal Lymphopoietin in Nickel-Induced Allergy in Mice

A Critical Role for Thymic Stromal Lymphopoietin in Nickel-Induced Allergy in Mice

T-cell recognition of chemicals, protein allergens and drugs: towards the development of in vitro assays

Imunopatologia da dermatite de contato alérgica

Contact Info

Product

Resources

About