T-cell receptors modify neuronal function in the central nervous system

Komal, Pragya; Nashmi, Raad

doi:10.1016/j.bcp.2015.07.023

Cited by 6 publications

(11 citation statements)

References 51 publications

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“…Additionally, the brain and pituitary are not the most likely organs to observe differential expression patterns caused by an infection. Interestingly, several studies have documented a neural function for most of the enriched immune response GO terms found in this study (reviewed by [48, 49]). E.g.…”

Section: Discussionmentioning

confidence: 77%

“…cytokines [50], Toll-like receptors [50], major histone complexes (MHC) [51–53], and T-cell receptors [48, 54, 55] have documented functions in neural development. Specifically, T-cell receptor signaling has been shown to be conveyed through cell-cell contact through MHC [55] and it has been speculated that the pruning of synapses of the visual system [56] can be facilitated by MHC/T-cell receptor signaling [48]. As such, there seems to be a high occurrence of genes with documented and connected neural functions among the differentially expressed genes related to immune functions found in the brain and pituitary in the current study.…”

Section: Discussionmentioning

confidence: 99%

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Cold seawater induces early sexual developmental stages in the BPG axis of European eel males

et al. 2019

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Background The impossibility of closing the life cycle of the European eel ( Anguilla anguilla ) in captivity troubles the future of this critically endangered species. In addition, the European eel is a highly valued and demanded resource, thus the successful closing of its life cycle would have a substantial economic and ecological impact. With the aim of obtaining the highest gamete quality, the study of the effects of environmental factors, such as temperature, on reproductive performance may prove valuable. This is especially true for the exposure to cold water, which has been reported to improve sexual development in multiple other Actinopterygii species. Results European eel males treated with cold seawater (10 °C, T10) for 2 weeks showed an increase in the proliferation and differentiation of spermatogonial cells until the differentiated spermatogonial type A cell stage, and elevated testosterone and 11-ketotestosterone plasma levels. Transcriptomes from the tissues of the brain-pituitary-gonad (BPG) axis of T10 samples revealed a differential gene expression profile compared to the other experimental groups, with clustering in a principal component analysis and in heat maps of all differentially expressed genes. Furthermore, a functional analysis of differentially expressed genes revealed enriched gene ontology terms involved in the regulation of circadian rhythm, histone modification, meiotic nuclear division, and others. Conclusions Cold seawater treatment had a clear effect on the activity of the BPG-axis of European eel males. In particular, our cold seawater treatment induces the synchronization and increased proliferation and differentiation of specific spermatogonial cells. In the transcriptomic results, genes related to thermoception were observed. This thermoception may have caused the observed effects through epigenetic mechanisms, since all analysed tissues further revealed differentially expressed genes involved in histone modification. The presented results support our hypothesis that a low temperature seawater treatment induces an early sexual developmental stage in European eels. This hypothesis is logical given that the average temperature experienced by eels in the early stages of their oceanic reproductive migration is highly similar to that of this cold seawater treatment. Further studies are needed to test whether a cold seawater treatment can improve the response of European eels to artificial hormonal treatment, as the results suggest. Electronic supplementary material The online version of this article (10.1186/s12864-019-5969-6) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 77%

Section: Discussionmentioning

confidence: 99%

Cold seawater induces early sexual developmental stages in the BPG axis of European eel males

et al. 2019

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“…Several neurotransmission systems have been involved in function and dysfunctional memory (e.g., Myhrer, 2003 ; Decker and McGaugh, 2004 ; Reis et al, 2009 ; Cassel, 2010 ; Rodríguez et al, 2012 ; Komal and Nashmi, 2015 ), including serotonin (5-hydroxytryptamine, 5-HT), which accounts with multiple neural markers (receptors, transporter; e.g., Hannon and Hoyer, 2008 ; Saulin et al, 2012 ; Seyedabadi et al, 2014 ; McCorvy and Roth, 2015 ). Indeed, the 5-HT system can be manipulated in multiple ways with pharmacological tools and possesses well characterized downstream signaling in mammals' species (e.g., Marin et al, 2012 ; McCorvy and Roth, 2015 ).…”

mentioning

confidence: 99%

Editorial: Serotonin and Memory

Meneses

Gasbarri

2016

Front. Pharmacol.

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mentioning

confidence: 68%

“…cytokines(Huising et al 2004), Toll-like receptors (Huising et al2004), major histone complexes (MHC; Corriveau et al 1998; Shatz 2009; Needleman et al 2010), and T-cell receptors (Syken and Shatz 2003; Komal and Nashmi 2015; Komal et al 2014) have documented functions in neural development. Specifically, T-cell receptor signaling has been shown to be conveyed through cell-cell contact through MHC (Komal et al 2014) and it hasbeen speculated that the pruning of synapsis of the visual system(Lee et al 2014) can be facilitated by MHC/T-cell receptor signaling(Komal and Nashmi 2015). As such, there seems to be a high occurrence of genes with documented and connected neural functions among the differentially expressed genes related to immune functions found in the brain and pituitary in the current study.…”

mentioning

confidence: 99%

Development of innovative methods for induction of European eel (Anguilla anguilla) spermatogenesis

Rozenfeld¹

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T-cell receptors modify neuronal function in the central nervous system

Cited by 6 publications

References 51 publications

Cold seawater induces early sexual developmental stages in the BPG axis of European eel males

Cold seawater induces early sexual developmental stages in the BPG axis of European eel males

Editorial: Serotonin and Memory

Development of innovative methods for induction of European eel (Anguilla anguilla) spermatogenesis

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