T Cell-Regulated Neutrophilic Inflammation in Autoinflammatory Diseases

Keller, M.; Spanou, Zoi; Schaerli, Patrick; Britschgi, Markus; Yawalkar, Nikhil; Seitz, Michael; Villiger, Peter M.; Pichler, Werner J.

doi:10.4049/jimmunol.175.11.7678

Cited by 114 publications

(78 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…CXCL8 is an important inflammatory mediator, predominantly responsible for the chemotaxis of neutrophils, although it also functions in T cell migration (Elenkov et al, 2005;Keller et al, 2005). In the present study, CXCL8 increased in control and weaned calves, indicating a non-specific response to stress.…”

Section: Variablesupporting

confidence: 43%

Biomarker responses to weaning stress in beef calves

O'Loughlin

McGee

Doyle

et al. 2014

Research in Veterinary Science

View full text Add to dashboard Cite

A B S T R A C TThe study objective was to investigate the physiological effects of weaning on beef calves and identify a panel of blood-based welfare biomarkers. On the day (d) of weaning (d 0), 16 spring-born, singlesuckled, beef bull calves that previously grazed with their dams at pasture, were assigned to one of two treatments: (1) control (n = 8), calves were loose-housed with their dam, (2) weaned (n = 8), calves were abruptly separated from their dam and loose-housed. Jugular blood was collected on d −4, 0, 1, 2, 3, 7, and 14 relative to weaning (d 0) and assayed for inflammatory and steroid variables. Total leukocyte counts were measured in whole blood. It is concluded that neutrophil number is a robust biomarker of stress and that plasma CXCL8 is a sensitive indicator of stress in weaned and control calves. In future studies, these two biomarkers should be central to the characterisation of stress responses.

show abstract

Section: Variablesupporting

confidence: 43%

Biomarker responses to weaning stress in beef calves

O'Loughlin

McGee

Doyle

et al. 2014

Research in Veterinary Science

View full text Add to dashboard Cite

show abstract

“…CXCR2 is activated by CXCL8 and this activation enhances the generation of reactive oxygen species and the phagocytosis of pathogens (20). CXCL8 is usually barely detectable in the normal skin, but strong CXCL8 production can be observed in psoriasis, atopic dermatitis, and acute generalized exanthematous pustulosis (21). In this report we show that CXCL8 is also abundantly present in the mycetoma lesions.…”

Section: Mycetoma Patients Express High Levels Of Cxcl8 During Infectionmentioning

confidence: 48%

Polymorphisms in Genes Involved in Innate Immunity Predispose Toward Mycetoma Susceptibility

Sande

Fahal

Verbrugh

et al. 2007

The Journal of Immunology

View full text Add to dashboard Cite

Madurella mycetomatis is the main causative agent of mycetoma, a tumorous fungal infection characterized by the infiltration of large numbers of neutrophils at the site of infection. In endemic areas the majority of inhabitants have Abs to M. mycetomatis, although only a small proportion of individuals actually develop mycetomal disease. It therefore appears that neutrophils are unable to clear the infection in some individuals. To test this hypothesis, 11 single nucleotide polymorphisms involved in neutrophil function were studied in a population of Sudanese mycetoma patients vs geographically and ethnically matched controls. Significant differences in allele distribution for IL-8 (CXCL8), its receptor CXCR2, thrombospondin-4 (TSP-4), NO synthase 2 (NOS2), and complement receptor 1 (CR1) were found. Further, the NOS2Lambaréné polymorphism was clearly associated with lesion size. The genotypes obtained for CXCL8, its receptor CXCR2, and TSP-4 all predisposed to a higher CXCL8 expression in patients, which was supported by the detection of significantly elevated levels of CXCL8 in patient serum. The NOS2 genotype observed in healthy controls was correlated with an increase in NOS2 expression and higher concentrations of nitrate and nitrite in control serum. We present the first evidence of human genetic predisposition toward susceptibility to mycetoma, a neglected infection of the poor.

show abstract

“…6, bottom panels). Expression of CCR8 by recruited macrophages is of particular note because of the link between CCR8 and other autoimmune disease states (25,32), and because it has not previously been studied in T1D.…”

Section: Macrophages Recruited To the Pancreas Express Chemokine Recementioning

confidence: 99%

Recruitment and Activation of Macrophages by Pathogenic CD4 T Cells in Type 1 Diabetes: Evidence for Involvement of CCR8 and CCL1

Cantor

Haskins

2007

The Journal of Immunology

View full text Add to dashboard Cite

Adoptive transfer of diabetogenic CD4 Th1 T cell clones into young NOD or NOD.scid recipients rapidly induces onset of diabetes and also provides a system for analysis of the pancreatic infiltrate. Although many reports have suggested a role for macrophages in the inflammatory response, there has been little direct characterization of macrophage activity in the pancreas. We showed previously that after migration to the pancreas, diabetogenic CD4 T cell clones produce a variety of inflammatory cytokines and chemokines, resulting in the recruitment of macrophages. In this study, we investigated mechanisms by which macrophages are recruited and activated by T cells. Analysis of infiltrating cells after adoptive transfer by the diabetogenic T cell clone BDC-2.5 indicates that large numbers of cells staining for both F4/80 and CD11b are recruited into the pancreas where they are activated to make IL-1β, TNF-α, and NO, and express the chemokine receptors CCR5, CXCR3, and CCR8. Diabetogenic CD4 T cell clones produce several inflammatory chemokines in vitro, but after adoptive transfer we found that the only chemokine that could be detected ex vivo was CCL1. These results provide the first evidence that CCR8/CCL1 interaction may play a role in type 1 diabetes through macrophage recruitment and activation.

show abstract

T Cell-Regulated Neutrophilic Inflammation in Autoinflammatory Diseases

Cited by 114 publications

References 44 publications

Biomarker responses to weaning stress in beef calves

Biomarker responses to weaning stress in beef calves

Polymorphisms in Genes Involved in Innate Immunity Predispose Toward Mycetoma Susceptibility

Recruitment and Activation of Macrophages by Pathogenic CD4 T Cells in Type 1 Diabetes: Evidence for Involvement of CCR8 and CCL1

Contact Info

Product

Resources

About