T Cells Engineered to Express Immunoreceptors Targeting the Frequently Expressed Medullary Thyroid Cancer Antigens Calcitonin, CEA, and RET M918T

Erickson, Timothy A.; Shih, Yi-Ping; Fass, Joseph; Jang, Myungkyu; Tran, Eric

doi:10.1089/thy.2022.0020

Cited by 4 publications

(2 citation statements)

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“…Erickson et al. ( 59 )reported the design and synthesis of a CAR-T cell targeting CEA for targeted therapy against MTC. The results of in vitro experiments clarified the binding ability of CEA CAR-T cells to their target.…”

Section: Targeting Of Car-t Cells For the Treatment Of Thyroid Cancermentioning

confidence: 99%

“…In addition to the targets mentioned above, no additional studies on CAR-T cell therapy for thyroid cancer have been reported. Based on the principles of CAR construction ( 63 ), we speculate that pan-tumor markers such as NIS, thyroglobulin(Tg), thyroid peroxidase(TPO), proto-oncogene tyrosine-protein kinase receptors(RET), calcitonin(CT), protein kinase B(PKB), telomerase reverse transcriptase (TERT), and the kinetochore element Ndc80 could be potential targets for thyroid cancer immunotherapy ( 59 , 64 ). However, further preliminary studies and clinical trials need to validate these speculations.…”

Section: Targeting Of Car-t Cells For the Treatment Of Thyroid Cancermentioning

confidence: 99%

See 1 more Smart Citation

CAR-T cell therapy in advanced thyroid cancer: from basic to clinical

Sun,

Wang,

Zhao

et al. 2024

Front. Immunol.

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The majority of patients with thyroid cancer can attain a favorable prognosis with a comprehensive treatment program based on surgical treatment. However, the current treatment options for advanced thyroid cancer are still limited. In recent years, chimeric antigen receptor-modified T-cell (CAR-T) therapy has received widespread attention in the field of oncology treatment. It has achieved remarkable results in the treatment of hematologic tumors. However, due to the constraints of multiple factors, the therapeutic efficacy of CAR-T therapy for solid tumors, including thyroid cancer, has not yet met expectations. This review outlines the fundamental structure and treatment strategies of CAR-T cells, provides an overview of the advancements in both preclinical investigations and clinical trials focusing on targets associated with CAR-T cell therapy in treating thyroid cancer, and discusses the challenges and solutions to CAR-T cell therapy for thyroid cancer. In conclusion, CAR-T cell therapy is a promising therapeutic approach for thyroid cancer, and we hope that our review will provide a timely and updated study of CAR-T cell therapy for thyroid cancer to advance the field.

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Section: Targeting Of Car-t Cells For the Treatment Of Thyroid Cancermentioning

confidence: 99%