T Cells Prepare for a Test: Can They Tolerate a Donor Heart?

Pullen, Lara C.

doi:10.1111/ajt.16663

Cited by 1 publication

(1 citation statement)

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“…There is a promising approach of co-transplantation of thymus and another donor organ, including heart, to reduce the risk of organ rejection. In this case, T cells from the donor thymus tissue are being depleted during in vitro culture, but the niche, consisting of TECs and stromal cells, required for the growth of the recipient T cells, remain intact and may favor the restoration of the recipient's immune system [126,127]. The question remains, if such revolutionary approaches can benefit patients with advanced atherosclerosis.…”

Section: Future Perspectives and Conclusionmentioning

confidence: 99%

Thymus in Cardiometabolic Impairments and Atherosclerosis: Not a Silent Player?

Kologrivova,

Naryzhnaya,

Suslova

2024

Biomedicines

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The thymus represents a primary organ of the immune system, harboring the generation and maturation of T lymphocytes. Starting from childhood, the thymus undergoes involution, being replaced with adipose tissue, and by an advanced age nearly all the thymus parenchyma is represented by adipocytes. This decline of thymic function is associated with compromised maturation and selection of T lymphocytes, which may directly impact the development of inflammation and induce various autoinflammatory disorders, including atherosclerosis. For a long time, thymus health in adults has been ignored. The process of adipogenesis in thymus and impact of thymic fat on cardiometabolism remains a mysterious process, with many issues being still unresolved. Meanwhile, thymus functional activity has a potential to be regulated, since islets of thymopoeisis remain in adults even at an advanced age. The present review describes the intricate process of thymic adipose involution, focusing on the issues of the thymus’ role in the development of atherosclerosis and metabolic health, tightly interconnected with the state of vessels. We also review the recent information on the key molecular pathways and biologically active substances that may be targeted to manipulate both thymic function and atherosclerosis.

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Section: Future Perspectives and Conclusionmentioning

confidence: 99%