T Helper 9 Cells: A New Player in Immune-Related Diseases

Chen, Jing; Guan, Lian; Tang, Lin; Liu, Shiming; Zhou, Yue; Chen, Chao; He, Zhisong; Xu, Lin

doi:10.1089/dna.2019.4729

Cited by 48 publications

(29 citation statements)

References 73 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The differentiation of multiple T helper subsets requires TGF-b, including the inflammatory Th17 and Th9 cells. 74,75 Membrane localization of TGF-b may help limit the recipients of this cytokine and ensure that it is presented in the context of other Treg promoting factors, thereby limiting the differentiation of inflammatory T-cell subsets. An unexplored area of TGF-b biology is whether the mode of TGF-b presentation (membrane-bound versus soluble) is one factor directing the pathway of T-cell differentiation in response to this multifunctional cytokine.…”

Section: Discussionmentioning

confidence: 99%

Human CD36^hi monocytes induce Foxp3⁺ CD25⁺ T cells with regulatory functions from CD4 and CD8 subsets

et al. 2021

View full text Add to dashboard Cite

The fetal and neonatal immune systems are uniquely poised to generate tolerance to self, maternal and environmental antigens encountered in the womb and shortly after birth. However, the tolerogenic nature of fetal and neonatal immunity can be detrimental in the context of pathogens, leading to overwhelming bacterial infections or chronic viral infections. A variety of mechanisms contribute to fetal and neonatal tolerance, including a propensity to generate Foxp3 + regulatory T cells (Treg cells). However, the mechanism(s) of fetal Foxp3 + T-cell differentiation, the specific antigen-presenting cells required and factors that inhibit Treg generation after the neonatal period are poorly understood. Here, we demonstrate that a subset of CD14 + monocytes expressing the scavenger molecule, CD36, can generate CD4 + and CD8 + T cells that coexpress Foxp3 and Tbet from both umbilical cord blood. These Foxp3 + T-bet + T cells potently suppress T-cell proliferation and ameliorate xenogeneic graft-versus-host disease. CD14 + CD36 + monocytes provide known Treg-inducing signals: membrane-bound transforming growth factor-beta and retinoic acid. Unexpectedly, adult peripheral blood monocytes are also capable of inducing Foxp3 + T cells from both cord blood and adult peripheral na€ ıve T cells. The induction of Foxp3 + T cells in umbilical cord blood by monocytes was inhibited by the lymphoid fraction of adult peripheral blood cells. These studies highlight a novel immunoregulatory role of monocytes and suggest that antigen presentation by CD36 hi monocytes may contribute to the peripheral development of Foxp3 + T-bet + T cells with regulatory functions in both neonates and adults.

show abstract

Section: Discussionmentioning

confidence: 99%

Human CD36^hi monocytes induce Foxp3⁺ CD25⁺ T cells with regulatory functions from CD4 and CD8 subsets

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Whereas RANTES and IP-10 are well-known chemoattractants for, e.g., activated T lymphocytes, IP-10 has been related to IFN-γ and Th1 signaling and less is known regarding IL-9 ( 22 , 51 , 52 ). A recently identified subpopulation of T lymphocytes (Th9 cells) has been identified as a major source for this pleiotropic cytokine, possibly explaining this association ( 53 ).…”

Section: Discussionmentioning

confidence: 99%

Niche- and Gender-Dependent Immune Reactions in Relation to the Microbiota Profile in Pediatric Patients with Otitis Media with Effusion

et al. 2020

View full text Add to dashboard Cite

Otitis media with effusion (OME) is a common inflammatory disease, primarily affecting children. OME is defined as a chronic low-grade inflammation of the middle ear (ME), without any signs of infection and with effusion persisting in the ME for more than three months. The precise pathogenesis is, however, not fully understood. Here, we comprehensively characterized and compared the host immune responses (inflammatory cells and mediators) and the overall microbial community composition (microbiota) present in matched middle ear effusion samples (MEE), external ear canal lavages, and nasopharynx (NPH) samples from children with OME. Female patients had significantly increased percentages of T lymphocytes and higher levels of a wide array of inflammatory mediators in their MEEs compared to male patients, which was unrelated to microbiota composition. The relative abundances of identified microorganisms were strongly associated with their niche of origin. Furthermore, specific inflammatory mediators were highly correlated with certain bacterial species. Interestingly, some organisms displayed a niche-driven inflammation pattern, where presence of Haemophilus spp and Corynebacterium propinquum in MEEs was accompanied by pro-inflammatory mediators, whereas their presence in NPH was accompanied by anti-inflammatory mediators. For Turicella and Alloiococcus we found exactly the opposite results, i.e., an anti-inflammatory profile when present in MEEs, whereas their presence in the NPH was accompanied by a pro-inflammatory profile. Altogether, our results indicate that immune responses in children with OME are highly niche- and microbiota-driven, but gender-based differences were also observed, providing novel insight into potential pathogenic mechanisms behind OME.

show abstract

“…As a new CD4 + T-cell subset, Th9 cells were first discovered in 2008 and are characterized by the secretion of the IL-9 cytokine [18]. Th9 cells can mediate tumor immunity and participate in autoimmune diseases or allergic diseases [19,20].…”

Section: Introductionmentioning

confidence: 99%

IL-9 and IL-9-producing cells in tumor immunity

Wan

et al. 2020

Cell Commun Signal

View full text Add to dashboard Cite

Interleukin (IL)-9 belongs to the IL-2Rγc chain family and is a multifunctional cytokine that can regulate the function of many kinds of cells. It was originally identified as a growth factor of T cells and mast cells. In previous studies, IL-9 was mainly involved in the development of allergic diseases, autoimmune diseases and parasite infections. Recently, IL-9, as a double-edged sword in the development of cancers, has attracted extensive attention. Since Thelper 9 (Th9) cell-derived IL-9 was verified to play a powerful antitumor role in solid tumors, an increasing number of researchers have started to pay attention to the role of IL-9-skewed CD8 + T (Tc9) cells, mast cells and Vδ2 T cellderived IL-9 in tumor immunity. Here, we review recent studies on IL-9 and several kinds of IL-9-producing cells in tumor immunity to provide useful insight into tumorigenesis and treatment.

show abstract

T Helper 9 Cells: A New Player in Immune-Related Diseases

Cited by 48 publications

References 73 publications

Human CD36^hi monocytes induce Foxp3⁺ CD25⁺ T cells with regulatory functions from CD4 and CD8 subsets

Human CD36^hi monocytes induce Foxp3⁺ CD25⁺ T cells with regulatory functions from CD4 and CD8 subsets

Niche- and Gender-Dependent Immune Reactions in Relation to the Microbiota Profile in Pediatric Patients with Otitis Media with Effusion

IL-9 and IL-9-producing cells in tumor immunity

Contact Info

Product

Resources

About

T Helper 9 Cells: A New Player in Immune-Related Diseases

Cited by 48 publications

References 73 publications

Human CD36hi monocytes induce Foxp3+ CD25+ T cells with regulatory functions from CD4 and CD8 subsets

Human CD36hi monocytes induce Foxp3+ CD25+ T cells with regulatory functions from CD4 and CD8 subsets

Niche- and Gender-Dependent Immune Reactions in Relation to the Microbiota Profile in Pediatric Patients with Otitis Media with Effusion

IL-9 and IL-9-producing cells in tumor immunity

Contact Info

Product

Resources

About

Human CD36^hi monocytes induce Foxp3⁺ CD25⁺ T cells with regulatory functions from CD4 and CD8 subsets

Human CD36^hi monocytes induce Foxp3⁺ CD25⁺ T cells with regulatory functions from CD4 and CD8 subsets