T- Lymphocyte Subset (CD4 /CD8) Ratios of Breast Cancer Patients in Basra-Iraq and Baku-Azerbaijan

Ghalib, Noori Nasr; Nasrullayeva, Gulnara; Qaziyev, A Y; Jawad, Khalil

doi:10.7314/apjcp.2016.17.s3.175

Cited by 5 publications

(3 citation statements)

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“…We were surprised to find that the Th/Tc (CD4:CD8) ratio is an independent prognostic factor for stage I- III BC. Th/Tc ratio repeatedly reports being associated with lymph node metastasis and the prognosis of triple-negative BC ( 44 , 48 – 52 ).…”

Section: Discussionmentioning

confidence: 88%

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Prognostic Evaluation of Metastasis-Related Lymphocyte/Monocyte Ratio in Stage Ⅰ-Ⅲ Breast Cancer Receiving Chemotherapy

et al. 2022

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PurposeThis study aims to clarify the prognostic significance of metastasis-related indicators in peripheral blood in stage I-III breast cancer (BC).MethodsThe clinicopathological data of 938 breast cancer patients and 509 benign breast disease patients were retrospectively analyzed, and fasting blood samples were collected before treatment. Univariate and multivariate regression analyses were used to evaluate factors related to metastasis risk and prognosis. The Kaplan-Meier method was used to generate survival curves, and the log-rank test was used to measure differences in survival between groups.ResultsUse the cut-off value (3.433) of LMR, the logistic regression analysis revealed that high carbohydrate antigen 153 (CA153), carbohydrate antigen 125 (CA125), carcinoembryonic antigen (CEA), killer T cell level, and low lymphocyte to monocyte ratio (LMR) level were significantly associated with BC distant metastasis. In contrast, LMR>=3.433 (HR: 0.409, 95%CI: 0.193–0.867, P = 0.020), Th/Tc ratio >=1.946 (HR: 0.378, 95% CI: 0.158–0.904, P =0.029) is regarded as a protective factor in the multivariate cox analyses. LMR is an independent prognostic factor for DFS in HER2-negative BC patients.ConclusionPeripheral blood parameters play an important role in predicting distant metastasis and prognosis of BC patients. As a potential marker, LMR can predict the metastasis and prognosis of patients with stage I-III BC.

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Section: Discussionmentioning

confidence: 88%

“…Both Th and Tc increase and participate in the immune response. Tc cells are the key effector cell population that mediates effective anti-tumor immunity ( 43 , 44 ). On the contrary, Th cells in the tumor have a negative prognostic effect on the prognosis of BC patients.…”

Section: Discussionmentioning

confidence: 99%

Prognostic Evaluation of Metastasis-Related Lymphocyte/Monocyte Ratio in Stage Ⅰ-Ⅲ Breast Cancer Receiving Chemotherapy

et al. 2022

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show abstract

“…T lymphocyte subsets are drastically reduced in cancer patients, indicating that the body's cellular immune activity is repressed and the ability to recognize and kill mutant cells is diminished. Moderate proportions and ratios of T cells in PBMC indicate healthy immunity and may contribute to a favorable prognosis 30 , 31 . Increased percentage of NK cells in colorectal cancer patients and monocytes in melanoma patients were discovered compared to healthy donors 19 , 32 .…”

Section: Discussionmentioning

confidence: 99%

The effects of aging, sex, and tumor burden on the peripheral blood immune cell profile and absolute counts

Xu,

Han,

Zhang

et al. 2024

J. Cancer

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Chemical compounds, anti-tumor and anti-neuropathic pain effect of hemp essential oil in vivo

Xu,

Luo,

Guo

et al. 2024

Fitoterapia

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T- Lymphocyte Subset (CD4 /CD8) Ratios of Breast Cancer Patients in Basra-Iraq and Baku-Azerbaijan

Cited by 5 publications

References 0 publications

Prognostic Evaluation of Metastasis-Related Lymphocyte/Monocyte Ratio in Stage Ⅰ-Ⅲ Breast Cancer Receiving Chemotherapy

Prognostic Evaluation of Metastasis-Related Lymphocyte/Monocyte Ratio in Stage Ⅰ-Ⅲ Breast Cancer Receiving Chemotherapy

The effects of aging, sex, and tumor burden on the peripheral blood immune cell profile and absolute counts

Chemical compounds, anti-tumor and anti-neuropathic pain effect of hemp essential oil in vivo

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