T-Lymphocytes as a Prognostic Indicator in Head and Neck Cancer

Schuller, David E.; Rock, Raymond P.; Rinehart, John J.; Koolemans-Beynen, Antoinette

doi:10.1001/archotol.1986.03780090034005

Cited by 14 publications

(6 citation statements)

References 16 publications

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“…PBL are the least immunosuppressed population of effector cells. Early in the disease process, PBL respond normally to mitogens such as phytohemagglutinin (PHA), concanavalin A (Con A), or other stimuli, whereas with progression of cancer, these responses deteriorate 72,78–87 . Patients with early stage HNSCC have normal T‐cell counts and CD4:CD8 ratios in their peripheral blood, whereas patients with advanced disease have reduced counts, decreased numbers of CD4+ cells, and small reductions in CD8+ cells 77,78,88–94 …”

Section: Discussionmentioning

confidence: 99%

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Covalent linking of proteins and cytokines to suture: Enhancing the immune response of head and neck cancer patients

et al. 2003

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Backgrwund:The immune system of advanced stage head and neck cancer patients is frequently suppressed. Poor immune function has been correlated with poor clinical outcome. Immunotherapeutic strategies have been previously attempted in an effort to enhance immune function and improve survival. Previous studies have shown surgical suture can be transformed into an immune stimulant capable of activating the T lymphocytes of cancer patients. The development of a process for covalently linking proteins and cytokines to suture could have enormous potential for the in vivo manipulation of the immune system. Hypothesis: We hypothesize proteins and cytokines can be covalently linked to surgical suture while preserving their functional properties. Study Design: Prospective study testing normal donor and head and neck squamous cell carcinoma (HNSCC) patient lymphocytes. Method. Polyester suture was acid hydrolyzed followed by reacting with l-ethyl-3(-3-dimethylamino propyl carbodiimide) (EDAC) to create a suture-EDAC intermediate. activity. The optimal conditions for linking 1C2 or m-7 were defined. The covalently linked cytokines retained their immune enhancing properties for stimulating PBL and lymph node lymphocytes (LNL) from HNSCC patients to proliferate, generate a TH1 immunologic profile of cytokines (IG2, IL-12, IFN-y), and stimulate T lymphocytes. Conclusion: This is the first report to demonstrate that cytokines can be covalently linked to surgical sutures and retain their immune-stimulating properties. Proteins linked to suture also retained their enzymatic activity. The clinical implications of functionally active cytokines or proteins linked to surgical suture may be very significant in the future for manipulating the immune system in vivo o r enhancing wound healing.

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Section: Discussionmentioning

confidence: 99%

“…HNSCC cells have been found to secrete a variety of factors that may account for immunosuppression. Prostaglandins (PGs) have been isolated from tumor extracts 59,105 as well as cancer cell lines 78 . PGs are known to down‐regulate T‐cell responses in a number of cancers.…”

Section: Discussionmentioning

confidence: 99%

Covalent linking of proteins and cytokines to suture: Enhancing the immune response of head and neck cancer patients

et al. 2003

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“…Promene u broju monocita i njihove funkcije su redovni pratilac malignih oboljenja. Broj monocita i njihova fagocitna aktivnost u razli~itom stepenu koreliraju sa malignomima razli~itih lokalizacija 3,4,11,15,23 . U našim rezultatima broj monocita i fagocitna aktivnost se odr'avaju iznad normalnih vrednosti.…”

Section: Diskusijaunclassified

“…Ovo je bilo izra'enije u toku pojave recidiva bolesti. Medjutim, nije pokazana direktna povezanost opisanih imunoloških poreme}aja sa stadijumima bolesti 11,12 . Funkcije T }elija u bolesnika sa malignim tumorima su ~esto duboko poreme}ene, a ve}i intenzitet tih poreme}aja obi~no prati napredovanje bolesti i mo'e da ima prognosti~ki zna~aj.…”

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“…Funkcije T }elija u bolesnika sa malignim tumorima su ~esto duboko poreme}ene, a ve}i intenzitet tih poreme}aja obi~no prati napredovanje bolesti i mo'e da ima prognosti~ki zna~aj. Ovo ilustruju rezultati brojnih istra'ivanja in vitro proliferativnog odgovora limfocita krvi na T }elijske mitogene 9,11,13 . Smanjen mitogeni odgovor limfocita zabele'en je u bolesnika sa karcinomom u podru~ju glave i vrata, a stepen ove supresije je pri tome bio srazmeran stadijumu bolesti i/ili je pokazao visok stepen korelacije sa tokom bolesti.…”

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T lymphocyte function in laryngectomized patients

et al. 2011

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T-Cell Subsets and Natural Killer Cell Function With Squamous Cell Carcinoma of the Head and Neck

Strome

Clark²,

Fried

et al. 1987

Archives of Otolaryngology - Head and Neck Surgery

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\s=b\ Twenty-two patients with squamous cell carcinoma of the head and neck were studied to assess potential abnormalities in total T lymphocytes, T4/T8 ratios, and natural killer cell function. Total T-cell counts were reduced for the entire group with the greatest reduction occurring in individuals with hypopharyngeal tumors and/or stage IV disease. Helper to suppressor ratios were within the norm for the total group, but specific site variances were detected in patients with oral cavity and hypopharyngeal primary carcinomas. Similarly altered T4/T8 ratios were noted with stage III disease. Substantive differences in natural killer cell activity were not observed. These data suggest that perturbations in T-lymphocyte subsets can be associated with decreased survival.

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T-Lymphocytes as a Prognostic Indicator in Head and Neck Cancer

Cited by 14 publications

References 16 publications

Covalent linking of proteins and cytokines to suture: Enhancing the immune response of head and neck cancer patients

Covalent linking of proteins and cytokines to suture: Enhancing the immune response of head and neck cancer patients

T lymphocyte function in laryngectomized patients

T-Cell Subsets and Natural Killer Cell Function With Squamous Cell Carcinoma of the Head and Neck

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