T-scope V4: miniaturized microscope for optogenetic tagging in freely behaving animals
Yuteng Wang,
Pablo Vergara,
Satoshi Hasegawa
et al.
Abstract:A miniaturized microscope (i.e., miniscope) enables the imaging of neuronal activity using calcium sensors while simultaneously manipulating that activity using opsins in freely moving animals. However, many miniscopes use light-emitting diodes with broadband emission, leading to unintentional opsin stimulation by light intended solely for calcium sensor activation (a phenomenon referred to as "biological crosstalk"). To address this issue, we previously developed a miniscope including a port for chosen light … Show more
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