2008
DOI: 10.1148/radiol.2483071602
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T2′ Imaging Predicts Infarct Growth beyond the Acute Diffusion-weighted Imaging Lesion in Acute Stroke

Abstract: The presence of a T2'>ADC mismatch is a more specific predictor of infarct growth than is TTP>ADC mismatch and hence may be of clinical value in patient selection for acute stroke therapies in the future.

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Cited by 44 publications
(39 citation statements)
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“…Changes in the BOLD effect are global, and are dependent on the oxygen consumption rate of tissue, blood volume, and washout of metabolites. Several reports and reviews of the clinical applications of SWI have suggested that it may be able to show increased oxygen extraction in regions of infarction or tissue hypoxemia [6,13,14,15,16]. Recently, several studies reported the presence of hypointense and enlarged vessels (CVS) in GRE sequences within acute ischemic territories due to major artery occlusion, and this was attributed to the BOLD effect secondary to elevated deoxyhemoglobin [1,2,3,4,8,9].…”
Section: Discussionmentioning
confidence: 99%
“…Changes in the BOLD effect are global, and are dependent on the oxygen consumption rate of tissue, blood volume, and washout of metabolites. Several reports and reviews of the clinical applications of SWI have suggested that it may be able to show increased oxygen extraction in regions of infarction or tissue hypoxemia [6,13,14,15,16]. Recently, several studies reported the presence of hypointense and enlarged vessels (CVS) in GRE sequences within acute ischemic territories due to major artery occlusion, and this was attributed to the BOLD effect secondary to elevated deoxyhemoglobin [1,2,3,4,8,9].…”
Section: Discussionmentioning
confidence: 99%
“…15 Furthermore, the imaging sequences used a spatial resolution of 1.25×1.25×2 mm 3 , which is considerably higher than in previously published studies on T2′ imaging. 15,20 The higher spatial resolution allows for a better delineation between the different tissue compartments (ie, ADC lesion and perfusion lesion) and reduces partial-volume effects, the latter presumably being the main reason why the setup presented here allowed to detect these significant differences.…”
Section: Differences Of T2′ Values Within Adc Lesions and Perfusion-rmentioning
confidence: 99%
“…This blood oxygen level-dependent effect is the technical basis of functional MRI, as well as for parts of susceptibility weighting and T29 imaging. Low T29 values are thought to represent areas with high oxygen consumption or high oxygen extraction fraction (93,94). The T29 values can be influenced by confounding factors such as microcalcifications, hemorrhage, and microvasculature.…”
Section: Petmentioning
confidence: 99%