T2*-weighted MR angiography substantially increases the detection of hemorrhage in the wall of brain abscess: implications in clinical interpretation

Gupta, Rakesh K.; Tomar, Vaishali; Awasthi, Rishi; Yadav, Abhishek; Husain, Nuzhat; Bharadwaj, V. K.; Ojha, Bal Krishna; Behari, Sanjay; Prasad, Kashi Nath; Rathore, Ram K.S.

doi:10.1007/s00234-011-0952-1

Cited by 18 publications

(7 citation statements)

References 36 publications

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“…To the best of our knowledge, this finding has not been reported. Although it was not mentioned by the authors, it can be retrospectively found in the pictorial essay published by Ong and Stuckey 10 and in another study by Gupta et al 13 Because the dual rim sign can be found in different studies, we believe it is a reliable imaging finding that can be used to differentiate abscesses from necrotic glioblastomas.…”

Section: Comparisons Of the Imaging Features Of The Lesion Margins Onmentioning

confidence: 71%

Differentiation of Pyogenic Brain Abscesses from Necrotic Glioblastomas with Use of Susceptibility-Weighted Imaging

Toh¹,

Wei

Chang

et al. 2012

AJNR Am J Neuroradiol

119

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Section: Comparisons Of the Imaging Features Of The Lesion Margins Onmentioning

confidence: 71%

Differentiation of Pyogenic Brain Abscesses from Necrotic Glioblastomas with Use of Susceptibility-Weighted Imaging

Toh¹,

Wei

Chang

et al. 2012

AJNR Am J Neuroradiol

119

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“…This was confirmed by a reduction in Mac-1 positive cells in treated DyW muscles. Moreover, it has been shown that fibrotic lesions—more specifically lesions with large amounts of collagen buildup—have a lower T 2 signal intensity [ 28 – 30 ]. Cardiac MRI studies in DMD subjects have reported an age related decrease in myocardial T 2 compared to controls [ 31 , 32 ] and an increase in myocardial T 2 heterogeneity [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

Magnetic Resonance Imaging Is Sensitive to Pathological Amelioration in a Model for Laminin-Deficient Congenital Muscular Dystrophy (MDC1A)

et al. 2015

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PurposeTo elucidate the reliability of MRI as a non-invasive tool for assessing in vivo muscle health and pathological amelioration in response to Losartan (Angiotensin II Type 1 receptor blocker) in DyW mice (mouse model for Laminin-deficient Congenital Muscular Dystrophy Type 1A).MethodsMultiparametric MR quantifications along with histological/biochemical analyses were utilized to measure muscle volume and composition in untreated and Losartan-treated 7-week old DyW mice.ResultsMRI shows that DyW mice have significantly less hind limb muscle volume and areas of hyperintensity that are absent in WT muscle. DyW mice also have significantly elevated muscle levels (suggestive of inflammation and edema). Muscle T2 returned to WT levels in response to Losartan treatment. When considering only muscle pixels without T2 elevation, DyW T2 levels are significantly lower than WT (suggestive of fibrosis) whereas Losartan-treated animals do not demonstrate this decrease in muscle T2. MRI measurements suggestive of elevated inflammation and fibrosis corroborate with increased Mac-1 positive cells as well as increased Picrosirius red staining/COL1a gene expression that is returned to WT levels in response to Losartan.ConclusionsMRI is sensitive to and tightly corresponds with pathological changes in DyW mice and thus is a viable and effective non-invasive tool for assessing pathological changes.

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“…In the past, it was considered that a hemorrhagic change in the walls of brain abscess is exceptional [ 8 ]. Recently, Gupta et al used 3T MRI and reported hemorrhage in the wall of brain abscess with 3D T2* susceptibility weighted angiography (SWAN), a variant of susceptibility weighted imaging, in 11 out of 15 cases [ 6 ]. In another series, Lai et al analyzed 14 cases of brain abscess with 1.5T MRI and did not identify hemorrhage in the walls of pyogenic brain abscess on susceptibility weighted imaging [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

“…Hemorrhage in the wall of pyogenic brain abscess is exceptional and its presence is considered to support a diagnosis of hemorrhagic tumor [ 1 – 5 ]. Recently, with the advent of susceptibility weighted imaging (SWI), occurrence of hemorrhagic changes in the wall of pyogenic abscess has been reported on 3T MRI but not on 1.5T MRI [ 6 , 7 ]. In this short series, we report three cases of pyogenic brain abscess demonstrating signals consistent with hemorrhage in SWI at 1.5T MRI.…”

Section: Introductionmentioning

confidence: 99%

Hemorrhage in the Wall of Pyogenic Brain Abscess on Susceptibility Weighted MR Sequence: A Report of 3 Cases

Thamburaj

Agarwal

Sabat

et al. 2014

Case Reports in Radiology

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Background and Purpose. In pyogenic brain abscess, hemorrhage in the walls is considered exceptional. Recently, hemorrhagic changes in the walls of pyogenic abscess have been demonstrated on susceptibility weighted imaging with 3T MRI. Here, we report hemorrhagic changes in the walls of pyogenic brain abscess on susceptibility weighted imaging with 1.5T MRI. Method. MRI of brain was done using 1.5T MRI with diffusion weighted sequence, susceptibility weighted sequence, and other standard sequences in 3 consecutive cases of pyogenic brain abscess. Stereotactic biopsy and cultures were obtained in 2 cases. One case was treated empirically with antibiotics. Results. Susceptibility sequence demonstrated hemorrhage in the wall of brain abscess in all three cases. All three cases also demonstrated restricted diffusion on diffusion weighted imaging. Conclusion. Susceptibility weighted imaging can demonstrate hemorrhagic changes in the walls of pyogenic brain abscess on 1.5T MRI. Presence of hemorrhage in the walls of ring enhancing lesions should not automatically lead to a diagnosis of tumor.

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T2*-weighted MR angiography substantially increases the detection of hemorrhage in the wall of brain abscess: implications in clinical interpretation

Cited by 18 publications

References 36 publications

Differentiation of Pyogenic Brain Abscesses from Necrotic Glioblastomas with Use of Susceptibility-Weighted Imaging

Differentiation of Pyogenic Brain Abscesses from Necrotic Glioblastomas with Use of Susceptibility-Weighted Imaging

Magnetic Resonance Imaging Is Sensitive to Pathological Amelioration in a Model for Laminin-Deficient Congenital Muscular Dystrophy (MDC1A)

Hemorrhage in the Wall of Pyogenic Brain Abscess on Susceptibility Weighted MR Sequence: A Report of 3 Cases

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