Tablet disintegration performance: Effect of compression pressure and storage conditions on surface liquid absorption and swelling kinetics

Investigating the role of excipients on the physical stability of directly compressed tablets

“…The data collected during the dynamic contact angle measurements were also modelled to provide information about the liquid absorption and swelling kinetics, which is discussed by Markl et al (2021) for tablets of each filler combination with CCS.…”

“…This classification process helped to identify the critical properties which influences the disintegration behaviour of the tablets. Following these classifications, the surface liquid-absorption and swelling processes were quantified using dynamic contact angle measurements for these formulations ( Markl et al, 2021 ). The liquid-absorption and swelling results supported the proposed mechanisms of disintegration for each formulation, with the disintegration of MCC/mannitol and MCC/lactose tablets primarily being influenced by the liquid absorption, whilst disintegration of MCC/DCPA tablets were generally swelling-controlled, and tablets composed of DCPA/lactose tablets showed some influence from both the liquid-absorption and swelling behaviour.…”

Tablet formulation development focusing on the functional behaviour of water uptake and swelling

“…Moreover, approximately similar results were measured for 5% PVPP as for 2% and 5% NaCMCXL, which might be explained by the tendency of NaCMCXL to form a GPN, limiting the water uptake and swelling at high disintegrant content ( Haware et al, 2008 ; Desai et al, 2014 ). Water uptake and swelling of tablets might further be related to their disintegration behaviour ( Markl et al, 2021 ). Zhao and Augsburger reported comparable disintegration times of tablets containing NaCMCXL and PVPP in equal proportion ( Zhao and Augsburger, 2005 ).…”

Formulation-dependent stability mechanisms affecting dissolution performance of directly compressed griseofulvin tablets

“…Videos were analysed using MATLAB (R2019a, MathWorks) to determine the contact angle between the droplet and the tablet surface at each frame. Further details on the processing of contact angle measurements are also provided by Markl et al (2021).…”

“…The griseofulvin tablets were formulated to correspond to previous work on placebo tablets (Maclean et al, 2021(Maclean et al, , 2022Markl et al, 2021), which investigated the performance-and stability-controlling disintegration mechanisms of placebo tablets. The formulations selected maintained the same concentrations of disintegrant and lubricant (5% and 1% wt., respectively) and a filler ratio of 1:1, however, the total concentration of filler was reduced to allow 30% wt.…”