Tablets made from paper

Stumpf, Florian; Keck, Cornelia M.

doi:10.1016/j.ijpharm.2018.05.071

Cited by 16 publications

(14 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The disintegration time of tablets produced from B1 was extremely rapid (i.e., 10 s, Table 3 ), which is consistent with previously reported data that indicated that such disintegration behavior might hinder the administration process of paper-based tablets and decrease patient compliance [ 4 ]. In contrast, the remaining batches, prepared with sucrose as a binder, produced tablets with a slower disintegration time.…”

Section: Resultssupporting

confidence: 88%

“…Due to this, the transfer of the smartFilms into appropriate oral dosage forms is important for improving patient compliance. Several studies already reported the successful compression of drug-loaded smartFilms into tablets without the addition of any excipients and demonstrated that the produced tablets fulfilled all requirements of the European Pharmacopeia [ 4 , 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

“…Nevertheless, paper sheets and smartFilms in their original state exhibit inadequate flowability, rendering them unsuitable candidates for high-speed tablet manufacturing and large scale tablet production [ 4 ]. In light of this, the transformation of smartFilms into a free-flowing physical form along with understanding their mechanical behavior under compression is a major prerequisite for a wider exploitation of the smartFilm technology, because it opens the possibility to produce smartFilm tablets on an industrial, large scale.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Tablets Made from Paper—An Industrially Feasible Approach

et al. 2022

View full text Add to dashboard Cite

Many orally administrated drugs exhibit poor bioavailability due to their limited solubility. The smartFilm technology is an innovative approach to improve the drug aqueous solubility, where the drug is embedded within the matrix of cellulose-based paper in an amorphous state, hence increasing its solubility. Despite its proven effectiveness, smartFilms, i.e., pieces of paper, exhibit limited flowability and are not easy to swallow, and thus oral administration is not convenient. In addition, there is a lack of knowledge of their mechanical behavior under compression. This study aimed to transform unloaded smartFilms, i.e., paper, into a flowable physical form and investigated its mechanical behavior when compressed. Granules made of paper were prepared via wet granulation and were compressed into tablets. The influence of using different amounts and forms of sucrose, as a binder, on the pharmaceutical properties of the produced granules and tablets was studied and the most suitable composition was identified by using instrumented die experiments. For this, the Poisson’s ratio and Young’s modulus were determined for different compaction force levels and the deformation behavior was estimated with the Heckel mathematical model. All granule batches showed good flowability with angle of repose values between 25–35°. Granule batches with ≤30% dry sucrose content produced tablets that fulfilled the European Pharmacopeia requirements, and the compaction behavior of the granules was found to be comparable to the behavior of classical binders and compression enhancers. Paper can be transferred into granules. These granules can be used as suitable intermediate products for the production of tablets made of paper in large, industrial scale.

show abstract

Section: Resultssupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Tablets Made from Paper—An Industrially Feasible Approach

et al. 2022

View full text Add to dashboard Cite

show abstract

“…After drying, the drug is located in the pores of the paper in an amorphous state. This technique is simple and requires no costly equipment [ 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

“…One reason is the inability to transform smartFilms, i.e., pieces of paper, into a convenient-to-swallow dosage form. This has been overcome by manually transferring paper into paper tablets [ 6 , 7 ]. These tablets were shown to possess sufficient pharmaceutical properties, i.e., they fulfilled the criteria required by the European Pharmacopeia.…”

Section: Introductionmentioning

confidence: 99%

Improving the Bioactivity of Norfloxacin with Tablets Made from Paper

2023

Self Cite

View full text Add to dashboard Cite

(1) Background: Many drugs possess poor bioavailability, and many strategies are available to overcome this issue. In this study, smartFilm technology, i.e., a porous cellulose matrix (paper), in which the active compound can be loaded onto in an amorphous state was utilised for oral administration to improve the solubility and bioactivity of a poorly soluble BSC class IV antibiotic. (2) Methods: Norfloxacin was used as the model drug and loaded into commercially available paper. The resulting norfloxacin-loaded smartFilms were transformed into smartFilm granules via wet granulation and the resulting norfloxacin-loaded smartFilm granules were transformed into norfloxacin-loaded tablets made from paper, i.e., smartFilm tablets. The crystalline state of norfloxacin was investigated, as well as the pharmaceutical properties of the granules and the tablets. The bioactivity of the smartFilm tablets was assessed in vitro and ex vivo to determine the antibacterial activity of norfloxacin. The results were compared to a physical mixture tablet that contained non-loaded paper granules and equal amounts of norfloxacin as a crystalline powder. (3) Results: Norfloxacin-loaded smartFilm granules and norfloxacin-loaded smartFilm tablets contained norfloxacin in an amorphous state, which resulted in an improved and faster release of norfloxacin when compared to the physical mixture tablet. The bioactivity was up to three times higher when compared to the physical mixture tablet. The ex vivo model was demonstrated to be a useful tool that allows for a fast and cost-effective discrimination between “good” and “bad” formulations. It provides realistic physiological conditions and can therefore yield meaningful, additional biopharmaceutical information that cannot be assessed in classical in vitro experiments. (4) Conclusions: smartFilm tablets are a promising, universal, industrially feasible and cost-effective formulation strategy for improved solubility and enhanced bioactivity of poorly soluble drugs.

show abstract