2022
DOI: 10.3390/ph15101188
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Tablets Made from Paper—An Industrially Feasible Approach

Abstract: Many orally administrated drugs exhibit poor bioavailability due to their limited solubility. The smartFilm technology is an innovative approach to improve the drug aqueous solubility, where the drug is embedded within the matrix of cellulose-based paper in an amorphous state, hence increasing its solubility. Despite its proven effectiveness, smartFilms, i.e., pieces of paper, exhibit limited flowability and are not easy to swallow, and thus oral administration is not convenient. In addition, there is a lack o… Show more

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Cited by 5 publications
(8 citation statements)
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“…Norfloxacin-loaded smartFilms and smartFilm granules were prepared as described previously [ 9 , 10 ], with slight modifications. In the first step, norfloxacin was dissolved in a mixture of acetone and ethanol (ratio of 1:1) to produce a solution that contained 2.5 mg/mL norfloxacin.…”
Section: Methodsmentioning
confidence: 99%
See 3 more Smart Citations
“…Norfloxacin-loaded smartFilms and smartFilm granules were prepared as described previously [ 9 , 10 ], with slight modifications. In the first step, norfloxacin was dissolved in a mixture of acetone and ethanol (ratio of 1:1) to produce a solution that contained 2.5 mg/mL norfloxacin.…”
Section: Methodsmentioning
confidence: 99%
“…A technology that cannot be produced on a large, industrial scale cannot be transferred into real world products. Therefore, a method that allows for the production of paper tablets on a larger scale was developed [ 9 ]. This method was a three-step process.…”
Section: Introductionmentioning
confidence: 99%
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“…129−131 This smart film-based tablet method was employed for model pharmaceuticals, sucrose, caffeine, and norfloxacin. 129,131,132 Such film-based tablets can not only be simple but also have high industrial adoptability due to their cost-effectiveness.…”
Section: Conclusion and Future Prospectsmentioning
confidence: 99%