Tablets With Material Gradients Fabricated by Three-Dimensional Printing

Yu, Deng Guang; Xiang, Yang; Huang, Wei; Liu, Jie; Wang, Yun Gan; Xu, Huibi

doi:10.1002/jps.20864

Cited by 146 publications

(61 citation statements)

References 16 publications

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“…Yu et al (2007) employed the method to construct a methacrylic or ethylcellulose matrix tablet to achieve a linear release of diclofenac sodium (59). The ability to construct complex formulation designs, even ones with loose powders in its inner regions, was also demonstrated using PB 3D printing (37,61).…”

Section: A Stereolithographic 3d Printing (Sla)mentioning

confidence: 99%

Emergence of 3D Printed Dosage Forms: Opportunities and Challenges

et al. 2016

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The recent introduction of the first FDA approved 3D-printed drug has fuelled interest in 3D printing technology, which is set to revolutionize healthcare. Since its initial use, this rapid prototyping (RP) technology has evolved to such as extent that it is currently being used in a wide range of applications including in tissue engineering, dentistry, construction, automotive and aerospace. However, in the pharmaceutical industry this technology is still in its infancy and its potential yet to be fully explored. This paper presents various 3D printing technologies such as stereolithographic, powder based, selective laser sintering, fused deposition modelling and semi-solid extrusion 3D printing. It also provides a comprehensive review of previous attempts at using 3D printing technologies on the manufacturing dosage forms with a particular focus on oral tablets. Their advantages particularly with adaptability in the pharmaceutical field have been highlighted, including design flexibility and control and manufacture which enables the preparation of dosage forms with complex designs and geometries, multiple actives and tailored release profiles. An insight into the technical challenges facing the different 3D printing technologies such as the formulation and processing parameters is provided. Light is also shed on the different regulatory challenges that need to be overcome for 3D printing to fulfil its real potential in the pharmaceutical industry.

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Section: A Stereolithographic 3d Printing (Sla)mentioning

confidence: 99%

Emergence of 3D Printed Dosage Forms: Opportunities and Challenges

et al. 2016

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“…In vitro drug release from 3D printed tablets was 43 extended up to 24 h. 44 FDM based 3D printing is a promising method to produce and control the dose of extended release tab- 45 lets, providing a highly adjustable, affordable, minimally sized, digitally controlled platform for producing 46 patient-tailored medicines. multilayer three dimensional fashion Yu et al, 84 2009;Yu et al, 2007). The proposed technology provided rapid dis-85 solving (Yu et al, 2007), extended release (Yu et al, 2009) and 86 multi-phase delayed release patterns .…”

mentioning

confidence: 97%

“…multilayer three dimensional fashion Yu et al, 84 2009;Yu et al, 2007). The proposed technology provided rapid dis-85 solving (Yu et al, 2007), extended release (Yu et al, 2009) and 86 multi-phase delayed release patterns . However, A series of tablets were printed according to Eq.…”

mentioning

confidence: 97%

Fabrication of extended-release patient-tailored prednisolone tablets via fused deposition modelling (FDM) 3D printing

Skowyra

Pietrzak

Alhnan

2015

European Journal of Pharmaceutical Sciences

470

274

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Rapid and reliable tailoring of the dose of controlled release tablets to suit an individual patient is a major challenge for personalized medicine. The aim of this work was to investigate the feasibility of using a fused deposition modelling (FDM) based 3D printer to fabricate extended release tablet using prednisolone loaded poly(vinyl alcohol) (PVA) filaments and to control its dose. Prednisolone was loaded into a PVA-based (1.75 mm) filament at approximately 1.9% w/w via incubation in a saturated methanolic solution of prednisolone. The physical form of the drug was assessed using differential scanning calorimetry (DSC) and X-ray powder diffraction (XRPD). Dose accuracy and in vitro drug release patterns were assessed using HPLC and pH change flow-through dissolution test. Prednisolone loaded PVA filament demonstrated an ability to be fabricated into regular ellipse-shaped solid tablets using the FDM-based 3D printer. It was possible to control the mass of printed tablet through manipulating the volume of the design (R(2) = 0.9983). On printing tablets with target drug contents of 2, 3, 4, 5, 7.5 and 10mg, a good correlation between target and achieved dose was obtained (R(2) = 0.9904) with a dose accuracy range of 88.7-107%. Thermal analysis and XRPD indicated that the majority of prednisolone existed in amorphous form within the tablets. In vitro drug release from 3D printed tablets was extended up to 24h. FDM based 3D printing is a promising method to produce and control the dose of extended release tablets, providing a highly adjustable, affordable, minimally sized, digitally controlled platform for producing patient-tailored medicines.

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“…These highly attractive technologies produce 3-dimensional objects of virtually any shape under the control of a computer software. Powder based 3D printing was first adapted to fabricating tablets with immediate (Pyrce Lewis et al, 2011;Wang et al, 2006;Yu et al, 2007), delayed release profiles (Fuh et al, 1999). In late 2015, the FDA approved the first 3D printed fast-dissolving tablets for treatment of epilepsy, Spritam ® (levetiracetam) (Aprecia, 2014;Yoo et al, 2014).…”

mentioning

confidence: 99%

Adaptation of pharmaceutical excipients to FDM 3D printing for the fabrication of patient-tailored immediate release tablets

Sadia

Sośnicka

Arafat

et al. 2016

International Journal of Pharmaceutics

274

147

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Abstract*Corresponding author: MAlbedAlhnan@uclan.ac.uk This work aims to employ fused deposition modelling 3D printing to fabricate immediate release pharmaceutical tablets with various model drugs. It investigates the addition of nonmelting filler to methacrylic matrix to facilitate FDM 3D printing and explore the impact of i) the nature of filler, ii) compatibility with the gears of the 3D printer and, and iii) polymer: filler ratio on the 3D printing process. A specially developed filament based on pharmaceutically approved methacrylic polymer (Eudragit E) and thermally stable filler, TCP (tribasic calcium phosphate) was optimised. Four model drugs (with different physicochemical properties were included into ready-to-use mechanically stable tablets with immediate release properties. Amongst the investigated fillers in this work, directly compressible lactose, spray-dried lactose and microcrystalline cellulose showed a level of degradation at 135 o C whilst talc and TCP allowed consistent flow of the filament and a successful 3D printing of the tablet. Following the two thermal processes (hot melt extrusion (HME) and fused deposition modelling (FDM) 3D printing), drug contents were 94.22%, 88.53%, 96.51% and 93.04% for 5-ASA, captopril, theophylline and prednisolone respectively. XRPD indicated that a fraction of 5-ASA, theophylline and prednisolone remained in the crystalline form whilst captopril was in amorphous form. By combining the advantages of thermally stable pharmaceutically approved polymers and fillers, this unique approach provides a low cost production method for on demand manufacturing of individualised dosage forms.

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Tablets With Material Gradients Fabricated by Three-Dimensional Printing

Cited by 146 publications

References 16 publications

Emergence of 3D Printed Dosage Forms: Opportunities and Challenges

Emergence of 3D Printed Dosage Forms: Opportunities and Challenges

Fabrication of extended-release patient-tailored prednisolone tablets via fused deposition modelling (FDM) 3D printing

Adaptation of pharmaceutical excipients to FDM 3D printing for the fabrication of patient-tailored immediate release tablets

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