Tackling the Burden of Osteoarthritis as a Health Care Opportunity in Indigenous Communities—A Call to Action

O’Brien, Penny; Bunzli, Samantha; Lin, Ivan; Gunatillake, Tilini; Bessarab, Dawn; Coffin, Juli; Garvey, Gail; Dowsey, Michelle M.; Choong, Peter

doi:10.3390/jcm9082393

Cited by 6 publications

(14 citation statements)

References 14 publications

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“…Disparities in TJR also cannot be explained by the prevalence of osteoarthritis, which is higher among Indigenous populations globally. 5 Instead, low rates of TJR are more likely due to disparities in healthcare access. 6 Aboriginal people experience barriers to, and disparities in healthcare along the whole of the pathway to receiving surgical care, including access to appropriate primary and specialist services.…”

Section: Discussionmentioning

confidence: 99%

“…These high‐demand, high‐volume procedures are considered safe and clinically effective interventions for people with end‐stage osteoarthritis 2 . Whilst the burden of osteoarthritis is high globally, the burden of osteoarthritis disproportionately affects certain population groups within each country 3‐5 . In Australia, the prevalence and burden of osteoarthritis among Aboriginal and Torres Strait Islander people (respectfully Aboriginal people herewith) is higher, yet access to primary care, specialist services and total joint replacement (TJR) by Aboriginal people is low 3,6,7 .…”

Section: Introductionmentioning

confidence: 99%

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Total joint replacement may be a valuable treatment for Aboriginal and Torres Strait Islander people with osteoarthritis, but uptake is low

O’Brien

Thuraisingam

Bunzli

et al. 2022

ANZ Journal of Surgery

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Background: Despite bearing a higher burden of osteoarthritis, little research has examined disparities in the access, utilisation and surgical outcomes associated with total joint replacement (TJR) among Aboriginal and Torres Strait Islander people. Methods: We conducted a retrospective cohort study to compare the sociodemographic and clinical characteristics of all Aboriginal and Torres Strait Islander and non-Aboriginal patients who underwent primary hip and knee replacement at St Vincent's Hospital Melbourne between 1996 and 2019. Results: A total of 10 277 primary total knee or hip replacements were performed in the 1996-2019 study period, of which 49 (0.5%) patients identified as either Aboriginal and/or Torres Strait Islander. Aboriginal and Torres Strait Islander patients were younger (61.7 AE 11.8 vs. 68.3 AE 10.3 years; P < 0.001), recorded higher Body Mass Index scores (median (IQR), 36.0 (29.5-41.4) vs. 30.8 (27.0-35.3); P < 0.001) and were more likely to experience multiple co-morbidities at the time of surgery. Despite these findings, Aboriginal and Torres Strait Islander patients did not experience higher complication rates and experienced comparable, clinically meaningful quality of life improvements 12-months postsurgery.Conclusions: TJR appears to be a valuable treatment option for Aboriginal and Torres Strait Islander people with end-stage osteoarthritis. Our study was limited by the small number of procedures conducted in patients who identify as Aboriginal and Torres Strait Islander. Further research is needed to understand why uptake of TJR by Aboriginal and Torres Strait Islander people is low.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Total joint replacement may be a valuable treatment for Aboriginal and Torres Strait Islander people with osteoarthritis, but uptake is low

O’Brien

Thuraisingam

Bunzli

et al. 2022

ANZ Journal of Surgery

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“…Knee osteoarthritis (OA) is a prevalent debilitating disease that results in healthcare burden worldwide [1]. Knee OA patients usually present with joint pain, swelling, tenderness and stiffness, which progressively worsens and hampers daily life activities.…”

Section: Introductionmentioning

confidence: 99%

Cytokine Profiling and Intra-Articular Injection of Autologous Platelet-Rich Plasma in Knee Osteoarthritis

Riewruja

Phakham

Sompolpong

et al. 2022

IJMS

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Osteoarthritis (OA) is a degenerative joint disease leading to joint pain and stiffness. Due to lack of effective treatments, physical and psychological disabilities caused by OA have a detrimental impact on the patient’s quality of life. Emerging evidence suggests that intra-articular injection of platelet-rich plasma (PRP) may provide favorable results since PRP comprises not only a high level of platelets but also a huge amount of cytokines, chemokines, and growth factors. However, the precise mechanism and standardization method remain uncertain. This study aimed to examine cytokine profiling in both PRP and platelet-poor plasma (PPP) of knee OA patients and to determine the effects of PRP on OA chondrocytes and knee OA patients. PRP contained a wide variety of cytokines, chemokines, growth factors, and autologous intra-articular PRP injection resulted in favorable outcomes in knee OA patients. Significant increases in levels of IL-1, IL-2, IL-7, IL-8, IL-9, IL-12, TNF-α, IL-17, PDGF-BB, bFGF, and MIP-1β were detected in PRP compared to PPP (p < 0.001). An in vitro study showed a marked increase in proliferation in OA chondrocytes cultured with PRP, compared to PPP and fetal bovine serum (p < 0.001). In a clinical study, knee OA patients treated with PRP showed improvement of physical function and pain, assessed by physical performance, Western Ontario and McMaster Universities Arthritis Index and visual analog scale. Our findings from both in vitro and clinical studies suggest that intra-articular PRP injection in knee OA patients may be a potential therapeutic strategy for alleviating knee pain and delaying the need for surgery.

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“…Addressing the burden associated with musculoskeletal conditions experienced by Aboriginal people is an emerging priority in Aboriginal health care and research [ 5 – 7 ]. The Australian Department of Health National Strategic Action Plan for Arthritis recommends providing information, education and support to people with arthritic conditions so that they can effectively self-manage their symptoms [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

“…Arthritis is highly prevalent in Indigenous communities in Australia, Canada, New Zealand and the United States of America [ 5 – 7 , 12 ]. In Australia, the prevalence of osteoarthritis in Aboriginal people is between 1.2 and 1.5 times higher than non-Aboriginal people [ 13 ] and the burden of disease is greater (31 Disability-Adjusted Life Years [DALY] per 1000 people for Aboriginal people versus 22 per 1000 people for non-Aboriginal people) [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Staying moving, staying strong: Protocol for developing culturally appropriate information for Aboriginal people with osteoarthritis, rheumatoid arthritis, lupus and gout

et al. 2021

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Introduction Addressing disparities in arthritis care is an important yet unmet health need for Aboriginal and Torres Strait Islander people in Australia (respectfully Aboriginal people herewith). Despite the significant prevalence and burden of arthritis within Aboriginal communities, access to care for arthritis is low. One means to reduce existing disparities in health care is to address current challenges relating to the appropriateness and acceptability of health care information resources for Aboriginal people. Health information sources can help to empower patients and their families to have greater involvement in their care and to engage in self-management of their condition. Despite an extensive range of arthritis information resources being available, currently no resources have been culturally adapted and developed in collaboration with Aboriginal consumers with arthritis. This paper outlines the processes that will be undertaken within the Staying Moving, Staying Strong project. This project aims to develop culturally secure arthritis information for Aboriginal people with osteoarthritis, rheumatoid arthritis, lupus and gout. Methods and analysis The overarching principle guiding this project is cultural security, referring to the incorporation of processes such that the research will not compromise the cultural rights, values and expectations of Aboriginal people. This project will prioritise partnerships, community engagement, community benefit, sustainability, transferability, and capacity building and therefore uphold the cultural rights and values of Aboriginal people. In this six-phase project we will; 1) Establish a community reference group and advisory committee; 2) Explore the health information needs and preferences of Aboriginal people with arthritis; 3) Synthesise the existing key recommendations in high quality clinical practice guidelines on arthritis care; 4) Culturally adapt key clinical recommendations; 5) Develop culturally appropriate arthritis resources and; 6) Qualitatively evaluate the developed resources.

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Tackling the Burden of Osteoarthritis as a Health Care Opportunity in Indigenous Communities—A Call to Action

Cited by 6 publications

References 14 publications

Total joint replacement may be a valuable treatment for Aboriginal and Torres Strait Islander people with osteoarthritis, but uptake is low

Total joint replacement may be a valuable treatment for Aboriginal and Torres Strait Islander people with osteoarthritis, but uptake is low

Cytokine Profiling and Intra-Articular Injection of Autologous Platelet-Rich Plasma in Knee Osteoarthritis

Staying moving, staying strong: Protocol for developing culturally appropriate information for Aboriginal people with osteoarthritis, rheumatoid arthritis, lupus and gout

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