2024
DOI: 10.1021/acs.chemrev.4c00423
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Tackling Undruggable Targets with Designer Peptidomimetics and Synthetic Biologics

Colin S. Swenson,
Gunasheil Mandava,
Deborah M. Thomas
et al.

Abstract: The development of potent, specific, and pharmacologically viable chemical probes and therapeutics is a central focus of chemical biology and therapeutic development. However, a significant portion of predicted disease-causal proteins have proven resistant to targeting by traditional small molecule and biologic modalities. Many of these so-called "undruggable" targets feature extended, dynamic protein−protein and protein−nucleic acid interfaces that are central to their roles in normal and diseased signaling p… Show more

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